{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:36:07Z","timestamp":1760240167991,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013285","name":"Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning","doi-asserted-by":"publisher","award":["No.2012-28"],"award-info":[{"award-number":["No.2012-28"]}],"id":[{"id":"10.13039\/501100013285","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central Universities","award":["15D110508, 15D110527, 13D110522, 17D210502, 17D310512, 18D210501, 18D310507, 2232014D3-39"],"award-info":[{"award-number":["15D110508, 15D110527, 13D110522, 17D210502, 17D310512, 18D210501, 18D310507, 2232014D3-39"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We report here the synthesis, characterization, and antibacterial evaluation of transition metal complexes of Ni, Cu, Co, Mn, Zn, and Cd (6a\u2013f), using a Schiff base ligand (5) derived from naproxen (an anti-inflammatory drug) and 5-bromosalicylaldehyde by a series of reactions. The ligand and the synthesized complexes were characterized by elemental analysis, UV-Visible, FTIR, and XRD techniques. The ligand 5 behaves as a bidentate donor and coordinates with metals in square planar or tetrahedral fashion. In order to evaluate its bioactivity profile, we screened the Schiff base ligand and its metal complexes (6a\u2013f) against different species of bacteria and the complexes were found to exhibit significant antibacterial activity. The complexes showed more potency against Bacillus subtilis as compared to the other species. Moreover, we modeled these complexes\u2019 binding affinity against COX1 protein using computational docking.<\/jats:p>","DOI":"10.3390\/molecules24071237","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T13:09:58Z","timestamp":1553864998000},"page":"1237","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Metal-Based Scaffolds of Schiff Bases Derived from Naproxen: Synthesis, Antibacterial Activities, and Molecular Docking Studies"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5578-5533","authenticated-orcid":false,"given":"Muhammad Ashraf","family":"Shaheen","sequence":"first","affiliation":[{"name":"Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China"},{"name":"Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehwish","family":"Anthony","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-9806","authenticated-orcid":false,"given":"Muhammad Nawaz","family":"Tahir","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Sargodha, Sargodha 40100, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mubashir","family":"Hassan","sequence":"additional","affiliation":[{"name":"Collage of Natural science, Department of Biology, Kongju National University, Gongju, Chungcheongnam 32588, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Yum","family":"Seo","sequence":"additional","affiliation":[{"name":"Collage of Natural science, Department of Biology, Kongju National University, Gongju, Chungcheongnam 32588, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Sciences and Humanities Prince Sattam bin Abdul Aziz University, Al-Kharj 11942, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9830-8235","authenticated-orcid":false,"given":"Mudassir","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Natural Sciences (SNS), National University of Sciences &amp; Technology (NUST), H-12, Islamabad 44000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6441-5112","authenticated-orcid":false,"given":"Muhammad","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Sargodha, Sub-campus, Bhakkar 30000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changrui","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1089\/ars.2010.3663","article-title":"Anticancer activity of metal complexes: Involvement of redox processes","volume":"15","author":"Ute","year":"2011","journal-title":"Antioxid. 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