{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:23:11Z","timestamp":1760523791222,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T00:00:00Z","timestamp":1555718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Organofluorine compounds are finding increasing application in a variety of fields such as pharmaceutical, agrochemical, and material sciences. However, given the scarcity of fluorine-containing natural products, advancement in this area depends almost entirely on the development of new synthetic methodologies. In this article, we present the synthesis of a series of previously undescribed (E)-\u03b2-fluorovinyl sulfones via a simple copper-catalyzed addition of hydrogen fluoride to alkynyl sulfone starting materials in varying yields and E\/Z selectivities. The hydrogenation of these products was also explored and compared with the hydrogenation of the related Z isomers. These new products may find interesting applications, given the versatility of vinyl sulfones in chemical synthesis and the unique properties of vinyl fluorides in biological settings.<\/jats:p>","DOI":"10.3390\/molecules24081569","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T11:02:53Z","timestamp":1555930973000},"page":"1569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Copper-Catalyzed Regioselective Synthesis of (E)-\u03b2-Fluorovinyl Sulfones"],"prefix":"10.3390","volume":"24","author":[{"given":"Raquel","family":"Rom\u00e1n","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Universitat de Val\u00e8ncia, 46100 Burjassot, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Barrio","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, Avda. Juli\u00e1n Claver\u00eda n\u00ba 8, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Mateu","sequence":"additional","affiliation":[{"name":"Laboratorio de Mol\u00e9culas Org\u00e1nicas, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, 46012 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Sedgwick","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Universitat de Val\u00e8ncia, 46100 Burjassot, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santos","family":"Fustero","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Universitat de Val\u00e8ncia, 46100 Burjassot, Spain"},{"name":"Laboratorio de Mol\u00e9culas Org\u00e1nicas, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, 46012 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1016\/S0040-4020(01)87882-0","article-title":"The chemistry of vinyl sulphones","volume":"46","author":"Simpkins","year":"1990","journal-title":"Tetrahedron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/med.20074","article-title":"Vinyl sulfones: Synthetic preparations and medicinal chemistry applications","volume":"26","author":"Meadows","year":"2006","journal-title":"Med. 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