{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:38:16Z","timestamp":1760240296220,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21772210, 41776169"],"award-info":[{"award-number":["21772210, 41776169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Science and Technology Project","award":["201804010462"],"award-info":[{"award-number":["201804010462"]}]},{"name":"the Natural Science Foundation of Guangdong Province","award":["2018A0303130219"],"award-info":[{"award-number":["2018A0303130219"]}]},{"name":"Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province","award":["GDME-2018C010"],"award-info":[{"award-number":["GDME-2018C010"]}]},{"name":"National Major Scientific and Technological Special Project for Significant New Drugs Development","award":["2018ZX09735001-002-003"],"award-info":[{"award-number":["2018ZX09735001-002-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A new macrodiolide, mangrovlide A (1) and two new polycyclic chromones, penixanthones C (2) and D (3), as well as four other known compounds (4\u20137), have been isolated from the mangrove sediment derived fungus Penicillium sp. SCSIO041218, cultured in the 0.25% NaCl rice substrate. The structures of the new compounds were determined by analysis of the NMR and MS spectroscopic data. Compound 1 possesses a 10-membered macrodiolide unit, while 2 and 3 are chromones with an unprecedented 6\/6\/6\/5 polycyclic skeleton. Compounds 1\u20137 were evaluated for their cytotoxicities, while all the compounds displayed weak or no activity.<\/jats:p>","DOI":"10.3390\/molecules24091686","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T08:51:44Z","timestamp":1556614304000},"page":"1686","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A New Macrodiolide and Two New Polycyclic Chromones from the Fungus Penicillium sp. SCSIO041218"],"prefix":"10.3390","volume":"24","author":[{"given":"Jingxia","family":"Huang","sequence":"first","affiliation":[{"name":"Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianglian","family":"She","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science of Technology, Wuhan 430081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiliang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science of Technology, Wuhan 430081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-resources and Ecology\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-4869","authenticated-orcid":false,"given":"Xuefeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-resources and Ecology\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-2484","authenticated-orcid":false,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-resources and Ecology\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1039\/C8NP00092A","article-title":"Marine natural products","volume":"36","author":"Carroll","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1039\/b301926h","article-title":"Marine-derived fungi: A chemically and biologically diverse group of microorganisms","volume":"21","author":"Bugni","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.3390\/md8102673","article-title":"Immense Essence of Excellence: Marine Microbial Bioactive Compounds","volume":"8","author":"Bhatnagar","year":"2010","journal-title":"Mar. Drugs"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.3390\/md13084594","article-title":"A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi","volume":"13","author":"Wang","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cofs.2018.04.001","article-title":"New aspects of ochratoxin A and citrinin biosynthesis in Penicillium","volume":"23","author":"Geisen","year":"2018","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11338","DOI":"10.3390\/molecules180911338","article-title":"Anticancer and Antifungal Compounds from Aspergillus, Penicillium and Other Filamentous Fungi","volume":"18","author":"Bladt","year":"2013","journal-title":"Molecules"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1016\/j.tet.2014.04.043","article-title":"New prenylated indole alkaloids from fungus Penicillium sp. derived of mangrove soil sample","volume":"70","author":"Yang","year":"2014","journal-title":"Tetrahedron"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1080\/14786419.2017.1297442","article-title":"Penixanthones A and B, two new xanthone derivatives from fungus Penicillium sp. SYFz-1 derived of mangrove soil sample","volume":"31","author":"Tao","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tet.2017.11.038","article-title":"Prenylated indole alkaloids and chromone derivatives from the fungus Penicillium sp. SCSIO041218","volume":"74","author":"Yang","year":"2018","journal-title":"Tetrahedron"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1039\/c2sc20096a","article-title":"Asymmetric Diels-Alder reaction of \u03b2,\u03b2-disubstituted enals and chromone-fused dienes: Construction of collections with high molecular complexity and skeletal diversity","volume":"3","author":"Li","year":"2012","journal-title":"Chem. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1016\/j.tet.2014.06.041","article-title":"Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp. KcF8 as a new class of PTP1B and SIRT1 inhibitors","volume":"70","author":"Ai","year":"2014","journal-title":"Tetrahedron"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1135\/cccc19920408","article-title":"(\u2212)-Mitorubrinol and Phthaldehydic Acids, New Metabolites of Penicillium vermiculatum DANG","volume":"57","author":"Proksa","year":"1992","journal-title":"Collect. Czech. Chem. C"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1139\/v90-319","article-title":"The metabolites of Talaromyces flavus. Part 2. Biological activity and biosynthetic studies","volume":"68","author":"Ayer","year":"1990","journal-title":"Can. J. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1139\/v90-318","article-title":"The metabolites of Talaromycesflavus: Part 1. Metabolites of the organic extracts","volume":"68","author":"Ayer","year":"1990","journal-title":"Can. J. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1039\/p19760002077","article-title":"The biosynthesis of fungal metabolites. Part IX. Sclerin: feedings with [1,2-13C] acetate and [methyl-13C]methionine","volume":"19","author":"Cox","year":"1976","journal-title":"J. Chem. Soc. Perkin Trans. 1"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00217-006-0252-x","article-title":"Thin-layer high-vacuum distillation to isolate volatile flavour compounds of cocoa powder","volume":"223","author":"Krings","year":"2006","journal-title":"Eur. Food Res. Technol."},{"key":"ref_17","first-page":"4489","article-title":"Synithesis of de-mevalonic acid (5-14C) lactone","volume":"11","author":"Pichat","year":"1968","journal-title":"Bull. Soc. Chim. Fr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Xu, Z., Wu, X., Li, G., Feng, Z., and Xu, J. (2019). Pestalotiopisorin B, a new isocoumarin derivative from the mangrove endophytic fungus Pestalotiopsis sp. HHL101. Nat. Prod. Res., 1\u20136.","DOI":"10.1080\/14786419.2018.1539980"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/9\/1686\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:48:08Z","timestamp":1760186888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/9\/1686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,30]]},"references-count":18,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["molecules24091686"],"URL":"https:\/\/doi.org\/10.3390\/molecules24091686","relation":{},"ISSN":["1420-3049"],"issn-type":[{"type":"electronic","value":"1420-3049"}],"subject":[],"published":{"date-parts":[[2019,4,30]]}}}