{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:53:29Z","timestamp":1777535609658,"version":"3.51.4"},"reference-count":63,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Two new complexes of Ru(II) with mixed ligands were prepared: [Ru(bpy)2smp](PF6) (1) and [Ru(phen)2smp](PF6) (2), in which smp = sulfamethoxypyridazine; bpy = 2,2\u2032-bipyridine; phen = 1,10-phenanthroline. The complexes have been characterized by elemental and conductivity analyses; infrared, NMR, and electrospray ionization mass spectroscopies; and X-ray diffraction of single crystal. Structural analyses reveal a distorted octahedral geometry around Ru(II) that is bound to two bpy (in 1) or two phen (in 2) via their two heterocyclic nitrogens and to two nitrogen atoms from sulfamethoxypyridazine\u2014one of the methoxypyridazine ring and the sulfonamidic nitrogen, which is deprotonated. Both complexes inhibit the growth of chronic myelogenous leukemia cells. The interaction of the complexes with bovine serum albumin and DNA is described. DNA footprinting using an oligonucleotide as substrate showed the complexes\u2019 preference for thymine base rich sites. It is worth notifying that the complexes interact with the Src homology SH3 domain of the Abl tyrosine kinase protein. Abl protein is involved in signal transduction and implicated in the development of chronic myelogenous leukemia. Nuclear magnetic resonance (NMR) studies of the interaction of complex 2 with the Abl-SH3 domain showed that the most affected residues were T79, G97, W99, and Y115.<\/jats:p>","DOI":"10.3390\/molecules24112154","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T11:35:05Z","timestamp":1559907305000},"page":"2154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents"],"prefix":"10.3390","volume":"24","author":[{"given":"Ariane C.C.","family":"de Melo","sequence":"first","affiliation":[{"name":"Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime M.S.V.P.","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelen J.R.C.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo L.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalia","family":"Castilho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Universidade Federal de Santa Catarina, Florian\u00f3polis 88040900, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipe","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Universidade Federal de Santa Catarina, Florian\u00f3polis 88040900, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-4084","authenticated-orcid":false,"given":"Adolfo H.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-4634","authenticated-orcid":false,"given":"Mayra de A.","family":"Marques","sequence":"additional","affiliation":[{"name":"Programa de Biologia Estrutural, Instituto de Bioqu\u00edmica M\u00e9dica Leopoldo de Meis, Instituto Nacional de Biologia Estrutural e Bioimagem, Centro Nacional de Resson\u00e2ncia Magn\u00e9tica Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941590, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-5888","authenticated-orcid":false,"given":"Guilherme A.P.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Programa de Biologia Estrutural, Instituto de Bioqu\u00edmica M\u00e9dica Leopoldo de Meis, Instituto Nacional de Biologia Estrutural e Bioimagem, Centro Nacional de Resson\u00e2ncia Magn\u00e9tica Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941590, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00cdvina P.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"},{"name":"Department of Chemistry, Centro Federal de Educa\u00e7\u00e3o Tecnol\u00f3gica de Minas Gerais, Belo Horizonte 30421-169, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hern\u00e1n","family":"Terenzi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Universidade Federal de Santa Catarina, Florian\u00f3polis 88040900, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-6232","authenticated-orcid":false,"given":"Elene C.","family":"Pereira-Maia","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"ref_1","first-page":"1799","article-title":"The successful regression of large solid sarcoma 180 tumors by platinum compounds","volume":"30","author":"Rosenberg","year":"1970","journal-title":"Cancer 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