{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:53:27Z","timestamp":1791658407683,"version":"4.3.4"},"reference-count":203,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The youth science and technology foundation program of Gansu Province of China","award":["17JR5RA181"],"award-info":[{"award-number":["17JR5RA181"]}]},{"name":"The application research and development project of Gansu Academy of Sciences of China","award":["2017JK-14"],"award-info":[{"award-number":["2017JK-14"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31560037"],"award-info":[{"award-number":["31560037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Group Project for Gansu Province of China","award":["1606RJA325"],"award-info":[{"award-number":["1606RJA325"]}]},{"name":"Innovation Team Construction Fund for Gansu Academy of Sciences of China","award":["2016TD-1"],"award-info":[{"award-number":["2016TD-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cordycepin (3\u2032-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris, has attracted much attention due to its therapeutic potential and biological value. Cordycepin interacts with multiple medicinal targets associated with cancer, tumor, inflammation, oxidant, polyadenylation of mRNA, etc. The investigation of the medicinal drug actions supports the discovery of novel targets and the development of new drugs to enhance the therapeutic potency and reduce toxicity. Cordycepin may be of great value owing to its medicinal potential as an external drug, such as in cosmeceutical, traumatic, antalgic and muscle strain applications. In addition, the biological application of cordycepin, for example, as a ligand, has been used to uncover molecular structures. Notably, studies that investigated the metabolic mechanisms of cordycepin-producing fungi have yielded significant information related to the biosynthesis of high levels of cordycepin. Here, we summarized the medicinal targets, biological applications, cytotoxicity, delivery carriers, stability, and pros\/cons of cordycepin in clinical applications, as well as described the metabolic mechanisms of cordycepin in cordycepin-producing fungi. We posit that new approaches, including single-cell analysis, have the potential to enhance medicinal potency and unravel all facets of metabolic mechanisms of cordycepin in Cordyceps militaris.<\/jats:p>","DOI":"10.3390\/molecules24122231","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T11:19:58Z","timestamp":1560511198000},"page":"2231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi"],"prefix":"10.3390","volume":"24","author":[{"given":"Peng","family":"Qin","sequence":"first","affiliation":[{"name":"Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-1739","authenticated-orcid":false,"given":"XiangKai","family":"Li","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, Gansu, China"},{"name":"Key Laboratory of Microbial Resources Exploition and Application of Gansu Province, Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ye","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, Gansu, China"},{"name":"Key Laboratory of Microbial Resources Exploition and Application of Gansu Province, Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DengXue","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"ref_1","unstructured":"(2018, September 12). Latest Global Cancer Data in 2018. Available online: http:\/\/www.iarc.fr\/en\/media-centre\/pr\/2018\/pdfs\/pr263_E.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3322\/caac.21338","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"Ca Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0005-2787(65)90483-1","article-title":"Isolation of 3\u2032-deoxyadenosine (cordycepin) from the liquid medium of Cordyceps militaris (L. ex Fr.) Link","volume":"95","author":"Frederiksen","year":"1965","journal-title":"Biochim. Et Biophys. Acta (Bba)-Nucleic Acids Protein Synth."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/166949a0","article-title":"Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link","volume":"166","author":"Cunningham","year":"1950","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1074\/jbc.M109.071159","article-title":"Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction","volume":"285","author":"Wong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1261\/rna.1458909","article-title":"Cordycepin interferes with 3\u2019 end formation in yeast independently of its potential to terminate RNA chain elongation","volume":"15","author":"Holbein","year":"2009","journal-title":"RNA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0092-8674(79)90220-4","article-title":"Synchronization of MEL cell commitment with cordycepin","volume":"18","author":"Levenson","year":"1979","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/nar\/gkm990","article-title":"Cordycepin-hypersensitive growth links elevated polyphosphate levels to inhibition of poly(A) polymerase in Saccharomyces cerevisiae","volume":"36","author":"Holbein","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wang, Z., Wu, X., Liang, Y.N., Wang, L., Song, Z.X., Liu, J.L., and Tang, Z.S. (2016). Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR. Molecules, 21.","DOI":"10.3390\/molecules21101267"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jnutbio.2016.12.008","article-title":"Cordycepin inhibits migration of human glioblastoma cells by affecting lysosomal degradation and protein phosphatase activation","volume":"41","author":"Hueng","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"12778","DOI":"10.3390\/ijms150712778","article-title":"Cordycepin down-regulates multiple drug resistant (MDR)\/HIF-1\u03b1 through regulating AMPK\/mTORC1 signaling in GBC-SD gallbladder cancer cells","volume":"15","author":"Wu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-013-0121-9","article-title":"Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin","volume":"4","author":"Tuli","year":"2013","journal-title":"3 Biotech."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1242\/jcs.115.16.3297","article-title":"Three-dimensional organization of active rRNA genes within the nucleolus","volume":"115","author":"Cheutin","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/pcp\/pch039","article-title":"Photosynthetic electron transport differentially regulates the expression of superoxide dismutase genes in liverwort, Marchantia paleacea var. diptera","volume":"45","author":"Sakaguchi","year":"2004","journal-title":"Plant. Cell Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.4049\/jimmunol.165.10.5788","article-title":"Amplification of IL-1-Induced Matrix Metalloproteinase-9 Expression by Superoxide in Rat Glomerular Mesangial Cells Is Mediated by Increased Activities of NF-B and Activating Protein-1 and Involves Activation of the Mitogen-Activated Protein Kinase Pathways","volume":"165","author":"Eberhardt","year":"2000","journal-title":"J. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1158\/0008-5472.CAN-08-4344","article-title":"Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells","volume":"69","author":"Bommareddy","year":"2009","journal-title":"Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.canlet.2016.04.001","article-title":"Cordycepin enhances Epstein-Barr virus lytic infection and Epstein-Barr virus-positive tumor treatment efficacy by doxorubicin","volume":"376","author":"Du","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/cns.12060","article-title":"Cordycepin suppresses excitatory synaptic transmission in rat hippocampal slices via a presynaptic mechanism","volume":"19","author":"Yao","year":"2013","journal-title":"Cns Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuro.2014.01.005","article-title":"The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells","volume":"41","author":"Jin","year":"2014","journal-title":"Neurotoxicology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kwon, H.W., Shin, J.H., Lim, D.H., Ok, W.J., Nam, G.S., Kim, M.J., Kwon, H.K., Noh, J.H., Lee, J.Y., and Kim, H.H. (2016). Antiplatelet and antithrombotic effects of cordycepin-enriched WIB-801CE from Cordyceps militaris ex vivo, in vivo, and in vitro. Bmc Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1463-8"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/s41467-018-03922-5","article-title":"Genome-wide excision repair in Arabidopsis is coupled to transcription and reflects circadian gene expression patterns","volume":"9","author":"Oztas","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.procbio.2013.10.017","article-title":"Efficient production of cordycepin by the Cordyceps militaris mutant G81-3 for practical use","volume":"49","author":"Masuda","year":"2014","journal-title":"Process. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1002\/jsfa.8097","article-title":"Evaluation of different agricultural wastes for the production of fruiting bodies and bioactive compounds by medicinal mushroom Cordyceps militaris","volume":"97","author":"Lin","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.chembiol.2017.09.001","article-title":"Fungal Cordycepin Biosynthesis Is Coupled with the Production of the Safeguard Molecule Pentostatin","volume":"24","author":"Xia","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"ref_25","first-page":"2375","article-title":"Isolation of 2\u2032-Deoxycoformycin and Cordycepin from Wheat Bran Culture of Aspergillus nidulans Y176\u20132","volume":"43","author":"Kodama","year":"1979","journal-title":"Agric. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.lfs.2013.09.030","article-title":"Cordycepin: A bioactive metabolite with therapeutic potential","volume":"93","author":"Tuli","year":"2013","journal-title":"Life Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3892\/ol.2015.3273","article-title":"Apoptosis and inhibition of proliferation of cancer cells induced by cordycepin","volume":"10","author":"Tian","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.phytochem.2008.01.027","article-title":"Cordyceps: A traditional Chinese medicine and another fungal therapeutic biofactory?","volume":"69","author":"Paterson","year":"2008","journal-title":"Phytochemistry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1080\/07388551.2017.1399102","article-title":"A review on the nucleic acid constituents in mushrooms: Nucleobases, nucleosides and nucleotides","volume":"38","author":"Phan","year":"2018","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jfda.2016.10.020","article-title":"Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review","volume":"25","author":"Chen","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"11645","DOI":"10.1021\/jf1028976","article-title":"Cordycepin induces apoptosis of CGTH W-2 thyroid carcinoma cells through the calcium-calpain-caspase 7-PARP pathway","volume":"58","author":"Chen","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.taap.2011.08.030","article-title":"Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor","volume":"257","author":"Choi","year":"2011","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jbiosc.2014.08.008","article-title":"Cordycepin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT","volume":"119","author":"Jang","year":"2015","journal-title":"J. Biosci. Bioeng."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.fct.2013.07.068","article-title":"Anti-cancer effect and apoptosis induction of cordycepin through DR3 pathway in the human colonic cancer cell HT-29","volume":"60","author":"Lee","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/15384101.2014.1000097","article-title":"Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells","volume":"14","author":"Liao","year":"2015","journal-title":"Cell Cycle"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tiv.2017.10.002","article-title":"Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy","volume":"46","author":"Chaicharoenaudomrung","year":"2018","journal-title":"Toxicol. Vitr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.biopha.2017.09.069","article-title":"Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K\/Akt\/mTOR and Nrf2\/HO-1\/NF-\u03baB pathway in mice","volume":"95","author":"Zeng","year":"2017","journal-title":"Biomed. Pharm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.tiv.2011.02.001","article-title":"Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells","volume":"25","author":"Jeong","year":"2011","journal-title":"Toxicol. Vitr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"12119","DOI":"10.3390\/ijms150712119","article-title":"Cordycepin inhibits lipopolysaccharide(LPS)-induced tumor necrosis factor (TNF)-\u03b1 production via activating amp-activated protein kinase (AMPK) signaling","volume":"15","author":"Zhang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_40","first-page":"417","article-title":"Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK\/Slug signaling pathway","volume":"7","author":"Hwang","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ko, B.S., Lu, Y.J., Yao, W.L., Liu, T.A., Tzean, S.S., Shen, T.L., and Liou, J.Y. (2013). Cordycepin Regulates GSK-3b\/b-Catenin Signaling in Human Leukemia Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076320"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.phymed.2013.03.008","article-title":"Elucidating the inhibitory mechanisms of the ethanolic extract of the fruiting body of the mushroom Antrodia cinnamomea on the proliferation and migration of murine leukemia WEHI-3 cells and their tumorigenicity in a BALB\/c allograft tumor model","volume":"20","author":"Liu","year":"2013","journal-title":"Phytomedicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2015.12.022","article-title":"Cordycepin increases radiosensitivity in cervical cancer cells by overriding or prolonging radiation-induced G2\/M arrest","volume":"771","author":"Hong","year":"2016","journal-title":"Eur. J. Pharm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00018-016-2346-3","article-title":"How cancer cells dictate their microenvironment: Present roles of extracellular vesicles","volume":"74","author":"Naito","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fendo.2017.00194","article-title":"The Emerging Roles of Extracellular Vesicles As Communication Vehicles within the Tumor Microenvironment and Beyond","volume":"8","author":"Sullivan","year":"2017","journal-title":"Front. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"43930","DOI":"10.1038\/srep43930","article-title":"Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity","volume":"7","author":"Liang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0167-5699(92)90008-U","article-title":"The origin and function of tumor-associated macrophages","volume":"13","author":"Mantovani","year":"1992","journal-title":"Immunol. Today"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2741\/3613","article-title":"ancer associated fibroblasts (CAFs) in tumor microenvironment","volume":"15","author":"Xing","year":"2010","journal-title":"Front. Biosci."},{"key":"ref_49","first-page":"1697","article-title":"Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt","volume":"40","author":"Jeong","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.phymed.2012.02.016","article-title":"Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K\/AKT signaling pathways","volume":"19","author":"Chen","year":"2012","journal-title":"Phytomedicine"},{"key":"ref_51","first-page":"255","article-title":"Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK\/AP-1 pathway in MCF-7 human breast cancer cells","volume":"25","author":"Noh","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Su, N.W., Wu, S.H., Chi, C.W., Liu, C.J., Tsai, T.H., and Chen, Y.J. (2017). Metronomic Cordycepin Therapy Prolongs Survival of Oral Cancer-Bearing Mice and Inhibits Epithelial-Mesenchymal Transition. Molecules, 22.","DOI":"10.3390\/molecules22040629"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/ptr.5305","article-title":"Apoptotic Effects of the Extracts of Cordyceps militaris via Erk Phosphorylation in a Renal Cell Carcinoma Cell Line","volume":"29","author":"Yamamoto","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_54","first-page":"41","article-title":"An Anti-Cancer Cordycepin Produced by Cordyceps militaris Growing on the Dead Larva of Bombyx mori Silkworm","volume":"6","author":"Aramwit","year":"2014","journal-title":"J. Agric. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Glosse, P., and Foller, M. (2018). AMP-Activated Protein Kinase (AMPK)-Dependent Regulation of Renal Transport. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113481"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1038\/sj.onc.1207892","article-title":"DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin\/TCF pathway","volume":"23","author":"Niida","year":"2004","journal-title":"Oncogene"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s10637-012-9859-x","article-title":"The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells","volume":"30","author":"Lee","year":"2012","journal-title":"Investig. New Drugs"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1365-2141.2007.06955.x","article-title":"RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells","volume":"140","author":"Chen","year":"2008","journal-title":"Br. J. Haematol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.1038\/srep13372","article-title":"Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K\/AKT signaling pathways","volume":"5","author":"Pan","year":"2015","journal-title":"Sci Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cbi.2014.03.010","article-title":"Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway","volume":"216","author":"Chen","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2249.2012.04580.x","article-title":"Cordycepin as a sensitizer to tumour necrosis factor (TNF)-\u03b1-induced apoptosis through eukaryotic translation initiation factor 2\u03b1 (eIF2\u03b1)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-\u03baB","volume":"168","author":"Kadomatsu","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/cdd.2011.63","article-title":"Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3\u2032-deoxyadenosine","volume":"18","author":"Kitamura","year":"2011","journal-title":"Cell Death Differ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1038\/sj.onc.1210407","article-title":"G protein regulation of MAPK networks","volume":"26","author":"Goldsmith","year":"2007","journal-title":"Oncogene"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1021\/jf205091b","article-title":"Cordycepin stimulated steroidogenesis in MA-10 mouse Leydig tumor cells through the protein kinase C Pathway","volume":"60","author":"Pao","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1021\/acs.jnatprod.5b00573","article-title":"N(6)-(2-Hydroxyethyl)adenosine in the Medicinal Mushroom Cordyceps cicadae Attenuates Lipopolysaccharide-Stimulated Pro-inflammatory Responses by Suppressing TLR4-Mediated NF-\u03baB Signaling Pathways","volume":"78","author":"Lu","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s00264-013-2219-4","article-title":"Cordycepin prevented IL-\u03b2-induced expression of inflammatory mediators in human osteoarthritis chondrocytes","volume":"38","author":"Ying","year":"2014","journal-title":"Int. Orthop."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.intimp.2015.04.017","article-title":"Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process","volume":"26","author":"Yang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.brainresbull.2016.09.010","article-title":"Cordycepin attenuates traumatic brain injury-induced impairments of blood-brain barrier integrity in rats","volume":"127","author":"Yuan","year":"2016","journal-title":"Brain Res. Bull."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2017.02.033","article-title":"Cordycepin diminishes thymic stromal lymphopoietin-induced interleukin-13 production","volume":"802","author":"Yoou","year":"2017","journal-title":"Eur J. Pharm."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejphar.2018.01.049","article-title":"Cordycepin rescues lidocaine-induced neurotoxicity in dorsal root ganglion by interacting with inflammatory signaling pathway MMP3","volume":"827","author":"Kan","year":"2018","journal-title":"Eur J. Pharm."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1021\/jf053111w","article-title":"Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage","volume":"54","author":"Yu","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3892\/ijmm.2014.1901","article-title":"In vitro evaluation of Cordyceps militaris as a potential radioprotective agent","volume":"34","author":"Jeong","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3109\/10715762.2011.647688","article-title":"Cordycepin inhibits albumin-induced epithelial-mesenchymal transition of renal tubular epithelial cells by reducing reactive oxygen species production","volume":"46","author":"Xiao","year":"2012","journal-title":"Free Radic Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.biopha.2016.03.009","article-title":"Cordycepin protects PC12 cells against 6-hydroxydopamine induced neurotoxicity via its antioxidant properties","volume":"81","author":"Olatunji","year":"2016","journal-title":"Biomed. Pharm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.exger.2012.09.003","article-title":"Cordycepin (3\u2032-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats","volume":"47","author":"Ramesh","year":"2012","journal-title":"Exp. Gerontol."},{"key":"ref_76","first-page":"640","article-title":"The inhibition of purine biosynthesis De novo in Bacillus subtilis by cordycepin","volume":"80","author":"Rottman","year":"1964","journal-title":"Biochim. Et Biophys. Acta"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1073\/pnas.68.11.2806","article-title":"Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication","volume":"68","author":"Philipson","year":"1971","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/excr.2002.5530","article-title":"Release of snRNP and RNA from transcription sites in adenovirus-infected cells","volume":"276","author":"Aspegren","year":"2002","journal-title":"Exp. Cell Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1073\/pnas.69.12.3820","article-title":"Cordycepin inhibits induction of murine leukovirus production by 5-iodo-2\u2019-deoxyuridine","volume":"69","author":"Wu","year":"1972","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/ijc.2910150311","article-title":"Effect of cordycepin on the replication of type-c RNA tumor viruses","volume":"15","author":"Richardson","year":"1975","journal-title":"Int. J. Cancer"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1128\/jvi.16.6.1575-1583.1975","article-title":"Effect of cordycepin (3\u2032-deoxyadenosine) on virus-specific RNA species synthesized in Newcastle disease virus-infected cells","volume":"16","author":"Weiss","year":"1975","journal-title":"J. Virol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1128\/jvi.20.1.170-176.1976","article-title":"Polyadenylate sequences of human rhinovirus and poliovirus RNA and cordycepin sensitivity of virus replication","volume":"20","author":"Nair","year":"1976","journal-title":"J. Virol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.17919","article-title":"Stimulation of in vitro translation of messenger RNA by actinomycin D and cordycepin","volume":"197","author":"Leinwand","year":"1977","journal-title":"Science"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/287355a0","article-title":"Inhibition of 40S-Met-tRNAfMet ribosomal initiation complex formation by vaccinia virus","volume":"287","author":"Person","year":"1980","journal-title":"Nature"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1128\/JVI.74.2.851-863.2000","article-title":"De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus","volume":"74","author":"Luo","year":"2000","journal-title":"J. Virol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1021\/jf990862n","article-title":"Cordycepin: Selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp.","volume":"48","author":"Ahn","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1128\/AAC.42.6.1424","article-title":"Antifungal activity of 3\u2032-deoxyadenosine (cordycepin)","volume":"42","author":"Sugar","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0140-6736(18)31364-3","article-title":"Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1\/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)","volume":"392","author":"Barouch","year":"2018","journal-title":"Lancet"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/ps.508","article-title":"Larvicidal activity against Plutella xylostella of cordycepin from the fruiting body of Cordyceps militaris","volume":"58","author":"Kim","year":"2002","journal-title":"Pest. Manag. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Vodnala, S.K., Ferella, M., Lunden-Miguel, H., Betha, E., van Reet, N., Amin, D.N., Oberg, B., Andersson, B., Kristensson, K., and Wigzell, H. (2009). Preclinical assessment of the treatment of second-stage African trypanosomiasis with cordycepin and deoxycoformycin. PLoS Negl. Trop. Dis., 3.","DOI":"10.1371\/journal.pntd.0000495"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1017\/S0031182012001990","article-title":"Cordycepin(3\u2032-deoxyadenosine) pentostatin (deoxycoformycin) combination treatment of mice experimentally infected with Trypanosoma evansi","volume":"140","author":"Gressler","year":"2013","journal-title":"Parasitology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.micpath.2015.05.005","article-title":"Dose finding of 3\u2019deoxyadenosine and deoxycoformycin for the treatment of Trypanosoma evansi infection: An effective and nontoxic dose","volume":"85","author":"Oliveira","year":"2015","journal-title":"Microb. Pathog."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"39","DOI":"10.7874\/kja.2013.17.2.39","article-title":"Aging","volume":"17","author":"Park","year":"2013","journal-title":"Korean J. Audiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.4028\/www.scientific.net\/AMR.750-752.1593","article-title":"Extraction and Antioxidant Property In Vitro of Cordycepin in Artificially Cultivated Cordyceps Militaris","volume":"750\u2013752","author":"He","year":"2013","journal-title":"Adv. Mater. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3858\/emm.2009.41.8.060","article-title":"Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappaB pathway in human dermal fibroblasts","volume":"41","author":"Lee","year":"2009","journal-title":"Exp. Mol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jep.2012.06.033","article-title":"Protective roles of Cordyceps on lung fibrosis in cellular and rat models","volume":"143","author":"Chen","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/labinvest.2013.4","article-title":"Blockade of Smad signaling by 3\u2019-deoxyadenosine: A mechanism for its anti-fibrotic potential","volume":"93","author":"Gu","year":"2013","journal-title":"Lab. Investig."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12012-013-9232-0","article-title":"Cordycepin, 3\u2032-Deoxyadenosine, Prevents Rat Hearts from Ischemia\/Reperfusion Injury Via Activation of Akt\/GSK-3 beta\/p70S6K Signaling Pathway and HO-1 Expression","volume":"14","author":"Park","year":"2014","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejphar.2011.04.052","article-title":"Cordycepin protects against cerebral ischemia\/reperfusion injury in vivo and in vitro","volume":"664","author":"Cheng","year":"2011","journal-title":"Eur J. Pharm."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2012.02.003","article-title":"Ras\/ERK1 pathway regulation of p27KIP1-mediated G1-phase cell-cycle arrest in cordycepin-induced inhibition of the proliferation of vascular smooth muscle cells","volume":"681","author":"Jung","year":"2012","journal-title":"Eur J. Pharm."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"927817","DOI":"10.1155\/2015\/927817","article-title":"Cordycepin Decreases Compound Action Potential Conduction of Frog Sciatic Nerve In Vitro Involving Ca(2+) -Dependent Mechanisms","volume":"2015","author":"Yao","year":"2015","journal-title":"Neural Plast."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1523\/JNEUROSCI.5085-14.2015","article-title":"Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming","volume":"35","author":"Ferrari","year":"2015","journal-title":"J. Neurosci"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jpain.2013.01.779","article-title":"Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat","volume":"14","author":"Ferrari","year":"2013","journal-title":"J. Pain"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2014.01.016","article-title":"Modulation effects of cordycepin on the skeletal muscle contraction of toad gastrocnemius muscle","volume":"726","author":"Yao","year":"2014","journal-title":"Eur J. Pharm."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1476-5381.2012.02005.x","article-title":"Blockade of adipocyte differentiation by cordycepin","volume":"167","author":"Takahashi","year":"2012","journal-title":"Br. J. Pharm."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fct.2013.07.033","article-title":"Protective effect of cordycepin-enriched Cordyceps militaris on alcoholic hepatotoxicity in Sprague-Dawley rats","volume":"60","author":"Cha","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1254\/jphs.10041FP","article-title":"Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase","volume":"113","author":"Guo","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/jcmm.12187","article-title":"Cordycepin activates AMP-activated protein kinase (AMPK) via interaction with the gamma1 subunit","volume":"18","author":"Wu","year":"2014","journal-title":"J. Cell Mol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"pyv112","DOI":"10.1093\/ijnp\/pyv112","article-title":"3\u2032-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway","volume":"19","author":"Li","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Dou, C., Cao, Z., Ding, N., Hou, T., Luo, F., Kang, F., Yang, X., Jiang, H., Xie, Z., and Hu, M. (2016). Cordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation. Nutrients, 8.","DOI":"10.3390\/nu8040231"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1159\/000480181","article-title":"The Protective Effect of Cordycepin On Alcohol-Induced Osteonecrosis of the Femoral Head","volume":"42","author":"Chen","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"548","DOI":"10.5483\/BMBRep.2016.49.10.071","article-title":"Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K\/Bapx1 and Notch signaling pathway","volume":"49","author":"Cao","year":"2016","journal-title":"Bmb Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1107\/S2052252517002433","article-title":"Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii","volume":"4","author":"Manszewski","year":"2017","journal-title":"IUCrJ"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jmb.2013.09.025","article-title":"Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases","volume":"426","author":"Yang","year":"2014","journal-title":"J. Mol. Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00204-007-0214-5","article-title":"Cordycepin induced eryptosis in mouse erythrocytes through a Ca2+-dependent pathway without caspase-3 activation","volume":"81","author":"Lui","year":"2007","journal-title":"Arch. Toxicol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Roy, S., Beauchemin, M., Dagenais-Bellefeuille, S., Letourneau, L., Cappadocia, M., and Morse, D. (2014). The Lingulodinium circadian system lacks rhythmic changes in transcript abundance. BMC Biol., 12.","DOI":"10.1186\/s12915-014-0107-z"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3389\/fpls.2016.00853","article-title":"Oligouridylate Binding Protein 1b Plays an Integral Role in Plant Heat Stress Tolerance","volume":"7","author":"Nguyen","year":"2016","journal-title":"Front. Plant. Sci."},{"key":"ref_118","first-page":"1019","article-title":"Induction of apoptosis by cordycepin in ADA-inhibited TdT-positive leukemia cells","volume":"10","author":"Koc","year":"1996","journal-title":"Leukemia"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.phymed.2014.07.014","article-title":"Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells","volume":"21","author":"Chou","year":"2014","journal-title":"Phytomedicine"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.3892\/mmr.2015.3928","article-title":"Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line","volume":"12","author":"Chen","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2119\/molmed.2011.00032","article-title":"Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP","volume":"17","author":"Kim","year":"2011","journal-title":"Mol. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3892\/ijo.2013.1762","article-title":"Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species mediated mitochondrial death pathway","volume":"42","author":"Lee","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3892\/or.2013.2589","article-title":"Cordycepin increases sensitivity of Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by inactivating the JNK signaling pathway","volume":"30","author":"Lee","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1142\/S0192415X15500950","article-title":"Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells: The Role of ERp57 and PGK-1","volume":"43","author":"Chen","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"11350","DOI":"10.3390\/molecules190811350","article-title":"Cordycepin induces S phase arrest and apoptosis in human gallbladder cancer cells","volume":"19","author":"Wang","year":"2014","journal-title":"Molecules"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.intimp.2017.03.002","article-title":"Cordycepin negatively modulates lipopolysaccharide-induced cytokine production by up-regulation of heme oxygenase-1","volume":"47","author":"Qing","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e1992","DOI":"10.7717\/peerj.1992","article-title":"Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc","volume":"4","author":"Li","year":"2016","journal-title":"PeerJ"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.biopha.2017.01.025","article-title":"Cordycepin inhibits airway remodeling in a rat model of chronic asthma","volume":"88","author":"Fei","year":"2017","journal-title":"Biomed. Pharm."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jep.2017.03.047","article-title":"Cordycepin-enriched WIB-801C from Cordyceps militaris improves functional recovery by attenuating blood-spinal cord barrier disruption after spinal cord injury","volume":"203","author":"Lee","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejphar.2017.10.029","article-title":"Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress","volume":"818","author":"Lei","year":"2018","journal-title":"Eur J. Pharm."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1097\/j.pain.0000000000000581","article-title":"Gi-protein-coupled 5-HT1B\/D receptor agonist sumatriptan induces type I hyperalgesic priming","volume":"157","author":"Araldi","year":"2016","journal-title":"Pain"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2459053","DOI":"10.1155\/2017\/2459053","article-title":"Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence\/Absence of Oxygen","volume":"2017","author":"Liu","year":"2017","journal-title":"Neural. Plast."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fmicb.2018.00058","article-title":"Cordycepin, a Characteristic Bioactive Constituent in Cordyceps militaris,Ameliorates Hyperuricemia through URAT1 in Hyperuricemic Mice","volume":"9","author":"Yong","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s11671-015-0851-1","article-title":"Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity","volume":"10","author":"Aramwit","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1021\/jf100269g","article-title":"Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps sinensis in rat","volume":"58","author":"Tsai","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1208\/s12249-017-0795-0","article-title":"Development of Cordycepin Formulations for Preclinical and Clinical Studies","volume":"18","author":"Lee","year":"2017","journal-title":"Aaps Pharmscitech."},{"key":"ref_137","unstructured":"OncoVista, I., and AAIPharma, I. (2009, January 09). Study of Cordycepin Plus Pentostatin in Patients With Refractory TdT-Positive Leukemia, Available online: https:\/\/clinicaltrials.gov\/show\/NCT00709215."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.2174\/0929867322666150625094705","article-title":"Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential","volume":"22","year":"2015","journal-title":"Curr. Med. Chem"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ejmech.2008.05.013","article-title":"Synthesis and pharmacokinetic evaluation of novel N-acyl-cordycepin derivatives with a normal alkyl chain","volume":"44","author":"Wei","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"9861","DOI":"10.1021\/jm401530a","article-title":"Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis","volume":"56","author":"Vodnala","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.biortech.2013.01.117","article-title":"Highly efficient and regioselective acylation of pharmacologically interesting cordycepin catalyzed by lipase in the eco-friendly solvent 2-methyltetrahydrofuran","volume":"133","author":"Chen","year":"2013","journal-title":"Bioresour. Technol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijpharm.2006.06.037","article-title":"Synthesis and properties of cordycepin intercalates of Mg-Al-nitrate layered double hydroxides","volume":"326","author":"Yang","year":"2006","journal-title":"Int J. Pharm."},{"key":"ref_143","first-page":"5207","article-title":"Targeted Delivery of Cordycepin to Liver Cancer Cells Using Transferrin-conjugated Liposomes","volume":"37","author":"Bi","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Federici, C., Petrucci, F., Caimi, S., Cesolini, A., Logozzi, M., Borghi, M., D\u2019Ilio, S., Lugini, L., Violante, N., and Azzarito, T. (2014). Exosome release and low pH belong to a framework of resistance of human melanoma cells to cisplatin. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088193"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/leu.2008.103","article-title":"Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration","volume":"22","author":"Chapuy","year":"2008","journal-title":"Leukemia"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ptr.5960","article-title":"Immunostimulatory effects of cordycepin-enriched WIB-801CE from Cordyceps militaris in splenocytes and cyclophosphamide-induced immunosuppressed mice","volume":"32","author":"Shin","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5598\/imafungus.2011.02.02.01","article-title":"One Fungus = One Name: DNA and fungal nomenclature twenty years after PCR","volume":"2","author":"Taylor","year":"2011","journal-title":"Ima Fungus"},{"key":"ref_148","first-page":"205","article-title":"On some entomogenous Sphaeriae","volume":"2","author":"Berkeley","year":"1843","journal-title":"Lond. J. Bot."},{"key":"ref_149","first-page":"277","article-title":"Enumeratio pyrenomycetum hypocreaceorum huscusque congnitorum systemate xarpologico dispositorum","volume":"1","author":"Saccardo","year":"1878","journal-title":"Michelia"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.carbpol.2016.01.036","article-title":"A comb-like branched \u03b2-d-glucan produced by a Cordyceps sinensis fungus and its protective effect against cyclophosphamide-induced immunosuppression in mice","volume":"142","author":"Hu","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3114\/sim.2007.57.01","article-title":"Phylogenetic classification of Cordyceps and the clavicipitaceous fungi","volume":"57","author":"Sung","year":"2007","journal-title":"Stud. Mycol."},{"key":"ref_152","first-page":"404","article-title":"Species identification and component detection of Ophiocordyceps sinensis cultivated by modern industry","volume":"35","author":"Wei","year":"2016","journal-title":"Mycosystema"},{"key":"ref_153","first-page":"245","article-title":"Names related to Cordyceps sinensis anamorph","volume":"84","author":"Jiangm","year":"2002","journal-title":"Mycotaxon"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1017\/S095375620100377X","article-title":"Molecular evidence for the anamorph\u2014teleomorph connection in Cordyceps sinensis","volume":"105","author":"Liu","year":"2001","journal-title":"Mycol. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/10826068.2013.833111","article-title":"Optimization of fermentation conditions and purification of cordycepin from Cordyceps militaris","volume":"44","author":"Jiapeng","year":"2014","journal-title":"Prep. Biochem. Biotechnol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1615\/IntJMedMushr.v16.i3.80","article-title":"Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms","volume":"16","author":"Cohen","year":"2014","journal-title":"Int J. Med. Mushrooms"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ygeno.2014.01.002","article-title":"Transcriptome analysis of the Ophiocordyceps sinensis fruiting body reveals putative genes involved in fruiting body development and cordycepin biosynthesis","volume":"103","author":"Xiang","year":"2014","journal-title":"Genomics"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jep.2018.02.007","article-title":"The pharmacological properties of Ophiocordyceps xuefengensis revealed by transcriptome analysis","volume":"219","author":"Jin","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"8059","DOI":"10.1007\/s00216-015-8978-6","article-title":"Identification of chemical markers in Cordyceps sinensis by HPLC-MS\/MS","volume":"407","author":"Hu","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"fnx181","DOI":"10.1093\/femsle\/fnx181","article-title":"A new cordycepin-producing caterpillar fungus Ophiocordyceps xuefengensis with artificial infection to the host, cultivation of mycelia and stromata","volume":"364","author":"Jin","year":"2017","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.enzmictec.2006.09.008","article-title":"Enhanced production of cordycepin by surface culture using the medicinal mushroom Cordyceps militaris","volume":"40","author":"Masuda","year":"2007","journal-title":"Enzym. Microb. Technol."},{"key":"ref_162","first-page":"3041","article-title":"Effects of additives on Cordycepin production using a Cordyceps militaris mutant induced by ion beam irradiation","volume":"8","author":"Das","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jpba.2009.04.027","article-title":"Determination of nucleosides and nucleobases in different species of Cordyceps by capillary electrophoresis-mass spectrometry","volume":"50","author":"Yang","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jbiosc.2010.08.018","article-title":"Production of cordycepin by a repeated batch culture of a Cordyceps militaris mutant obtained by proton beam irradiation","volume":"111","author":"Masuda","year":"2011","journal-title":"J. Biosci. Bioeng."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1590\/S1517-83822012000200004","article-title":"Characterizations of a new Cordyceps cicadae isolate and production of adenosine and cordycepin","volume":"43","author":"Wang","year":"2012","journal-title":"Braz J. Microbiol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"20808","DOI":"10.3390\/molecules191220808","article-title":"Optimization of ultrasonic-assisted extraction of cordycepin from Cordyceps militaris using orthogonal experimental design","volume":"19","author":"Wang","year":"2014","journal-title":"Molecules"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13568-015-0140-5","article-title":"Effect of the salts of deep ocean water on the production of cordycepin and adenosine of Cordyceps militaris-fermented product","volume":"5","author":"Hung","year":"2015","journal-title":"Amb Express"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s12257-016-0405-0","article-title":"Improved cordycepin production in a liquid surface culture of Cordyceps militaris isolated from wild strain","volume":"21","author":"Sari","year":"2016","journal-title":"Biotechnol. Bioprocess. Eng."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5941\/MYCO.2017.45.1.31","article-title":"Development of High Cordycepin-Producing Cordyceps militaris Strains","volume":"45","author":"Kang","year":"2017","journal-title":"Mycobiology"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Suparmin, A., Kato, T., Dohra, H., and Park, E.Y. (2017). Insight into cordycepin biosynthesis of Cordyceps militaris: Comparison between a liquid surface culture and a submerged culture through transcriptomic analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187052"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jbiotec.2017.08.021","article-title":"Genome shuffling improved the nucleosides production in Cordyceps kyushuensis","volume":"260","author":"Wang","year":"2017","journal-title":"J. Biotechnol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1007\/s00253-018-8899-3","article-title":"Heat and light stresses affect metabolite production in the fruit body of the medicinal mushroom Cordyceps militaris","volume":"102","author":"Zhang","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jfda.2016.11.021","article-title":"Optimal conditions for cordycepin production in surface liquid-cultured Cordyceps militaris treated with porcine liver extracts for suppression of oral cancer","volume":"26","author":"Lin","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.2298\/ABS1404411M","article-title":"Cordyceps pruinosa produces cordycepin and N6-(2-hydroxyethyl)-adenosine in culture","volume":"66","author":"Meng","year":"2014","journal-title":"Arch. Biol. Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ygeno.2017.09.008","article-title":"Transcriptome analysis of Paecilomyces hepiali at different growth stages and culture additives to reveal putative genes in cordycepin biosynthesis","volume":"110","author":"Pang","year":"2018","journal-title":"Genomics"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1038\/s41598-017-01869-z","article-title":"The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity","volume":"7","author":"Xia","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00253-015-7047-6","article-title":"The blue-light receptor CmWC-1 mediates fruit body development and secondary metabolism in Cordyceps militaris","volume":"100","author":"Yang","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/1574-6968.12393","article-title":"Photo morphogenesis and photo response of the blue-light receptor gene Cmwc-1 in different strains of Cordyceps militaris","volume":"352","author":"Yang","year":"2014","journal-title":"Fems Microbiol. Lett."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1007\/s00253-017-8276-7","article-title":"DASH-type cryptochromes regulate fruiting body development and secondary metabolism differently than CmWC-1 in the fungus Cordyceps militaris","volume":"101","author":"Wang","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0006-3002(61)90546-7","article-title":"Studies on the biosynthesis of cordycepin","volume":"47","author":"Kredich","year":"1961","journal-title":"Biochim. Et Biophys. Acta"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0005-2787(69)90181-6","article-title":"Nucleoside antibiotics. IV. Metabolic fate of adenosine and cordycepin by Cordyceps militaris during cordycepin biosynthesis","volume":"182","author":"Chassy","year":"1969","journal-title":"Biochim. Et Biophys. Acta"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/0005-2787(76)90017-4","article-title":"Biosynthesis of 3\u2032-deoxyadenosine by Cordyceps militaris. Mechanism of reduction","volume":"425","author":"Lennon","year":"1976","journal-title":"Biochim. Et Biophys. Acta"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"R116","DOI":"10.1186\/gb-2011-12-11-r116","article-title":"Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional Chinese medicine","volume":"12","author":"Zheng","year":"2011","journal-title":"Genome Biol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bej.2011.09.014","article-title":"Enhancement of cordycepin production in submerged cultures of Cordyceps militaris by addition of ferrous sulfate","volume":"60","author":"Fan","year":"2012","journal-title":"Biochem. Eng. J."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4172\/2165-8056.1000134","article-title":"The strategies for increasing cordycepin production of Cordyceps militaris by liquid fermentation","volume":"6","author":"Zhang","year":"2016","journal-title":"Fungal Genom. Biol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1615\/IntJMedMushrooms.v17.i11.80","article-title":"Cordyceps s.L. (Ascomycetes) species used as medicinal mushrooms are closely related with higher ability to produce cordycepin","volume":"17","author":"Kuo","year":"2016","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.gene.2017.05.027","article-title":"Genome-scale metabolic network of Cordyceps militaris useful for comparative analysis of entomopathogenic fungi","volume":"626","author":"Vongsangnak","year":"2017","journal-title":"Gene"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s12010-017-2400-0","article-title":"Functional Analysis of Ribonucleotide Reductase from Cordyceps militaris Expressed in Escherichia coli","volume":"182","author":"Kato","year":"2017","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.chembiol.2016.12.012","article-title":"An unusual protector-prote\u00b4 ge\u00b4 strategy for the biosynthesis of purine nucleoside antibiotics","volume":"24","author":"Wu","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"e00121","DOI":"10.1002\/prp2.121","article-title":"Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances","volume":"3","author":"Li","year":"2015","journal-title":"Pharm. Res. Perspect"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Yin, Y., Yu, G., Chen, Y., Jiang, S., Wang, M., Jin, Y., Lan, X., Liang, Y., and Sun, H. (2012). Genome-wide transcriptome and proteome analysis on different developmental stages of Cordyceps militaris. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051853"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.mib.2012.10.002","article-title":"Reactive oxygen species generation in fungal development and pathogenesis","volume":"15","author":"Tudzynski","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_193","first-page":"3142","article-title":"Research progress of host insect of Cordyceps and its raising technique","volume":"12","author":"Li","year":"2017","journal-title":"World Chin. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1111\/mec.12940","article-title":"Phylogeography and evolution of a fungal-insect association on the Tibetan Plateau","volume":"23","author":"Zhang","year":"2014","journal-title":"Mol. Ecol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/nar\/gkt932","article-title":"Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630","volume":"42","author":"Chen","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural Products as Sources of New Drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1039\/C6NP00048G","article-title":"Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites","volume":"34","author":"Covington","year":"2017","journal-title":"Nat. Prod. Rep."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41586-018-0056-8","article-title":"Nanoscale synthesis and affinity ranking","volume":"557","author":"Gesmundo","year":"2018","journal-title":"Nature"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrc.2017.58","article-title":"Unravelling biology and shifting paradigms in cancer with single-cell sequencing","volume":"17","author":"Baslan","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tig.2018.06.001","article-title":"Single-Cell Multi-omics: An Engine for New Quantitative Models of Gene Regulation","volume":"34","author":"Packer","year":"2018","journal-title":"Trends Genet."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1126\/science.aam8999","article-title":"Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding","volume":"360","author":"Rosenberg","year":"2018","journal-title":"Science"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrc.2017.41","article-title":"Imaging of anticancer drug action in single cells","volume":"17","author":"Miller","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nbt.4184","article-title":"A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies","volume":"36","author":"Jing","year":"2018","journal-title":"Nat. Biotechnol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/12\/2231\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:58:36Z","timestamp":1760187516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/12\/2231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,14]]},"references-count":203,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["molecules24122231"],"URL":"https:\/\/doi.org\/10.3390\/molecules24122231","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,14]]}}}