{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:17:56Z","timestamp":1790522276976,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003720","name":"Korea Atomic Energy Research Institute","doi-asserted-by":"publisher","award":["523320-19"],"award-info":[{"award-number":["523320-19"]}],"id":[{"id":"10.13039\/501100003720","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Two new phenanthrenes, (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one (1) and 2,7-dihydroxy-phenanthrene-1,4-dione (2), were isolated from the ethyl acetate-soluble fraction of Dendrobii Herba, together with seven known phenanthrenes (3\u20139), two bibenzyls (10\u201312), and a lignan (13). Structures of 1 and 2 were elucidated by analyzing one-dimensional (1D) and two-dimensional (2D)-NMR and High-resolution electrospray ionization mass spectra (HR-ESI-MS) data. The absolute configuration of compound 1 was confirmed by the circular dichroism (CD) spectroscopic method. In cytotoxicity assay using FaDu human hypopharynx squamous carcinoma cell line, compounds 3\u20136, 8, 10, and 12 showed activities, with IC50 values that ranged from 2.55 to 17.70 \u03bcM.<\/jats:p>","DOI":"10.3390\/molecules24122339","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T10:52:31Z","timestamp":1561459951000},"page":"2339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identification of Two New Phenanthrenes from Dendrobii Herba and Their Cytotoxicity towards Human Hypopharynx Squamous Carcinoma Cell (FaDu)"],"prefix":"10.3390","volume":"24","author":[{"given":"Bomi","family":"Nam","sequence":"first","affiliation":[{"name":"Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do 56212, Korea"},{"name":"College of Pharmacy, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Mok","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Biosystems and Biotechnology, Korea University, Seoul 02841, Korea"},{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do 58245, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biosystems and Biotechnology, Korea University, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Hun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head &amp; Neck Surgery, School of Medicine, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-8862","authenticated-orcid":false,"given":"Chang Hyun","family":"Jin","sequence":"additional","affiliation":[{"name":"Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do 56212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Baek","family":"Kim","sequence":"additional","affiliation":[{"name":"Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do 56212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik-Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-4441","authenticated-orcid":false,"given":"Ah-Reum","family":"Han","sequence":"additional","affiliation":[{"name":"Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do 56212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"841752","DOI":"10.1155\/2015\/841752","article-title":"Evaluation of chemical constituents and important mechanism of pharmacological biology in Dendrobium plants","volume":"2015","author":"Lam","year":"2015","journal-title":"Evid.-Based Complement. 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