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The pathogenesis of HCC is complex, involving multiple processes including abnormal cell and tissue regeneration, angiogenesis, genomic instability, cellular proliferation, and signaling pathway alterations. Capsaicin is a substance that holds increasingly high interest and is studied as a therapeutic option in a wide array of diseases. Several studies have investigated capsaicin roles in various stages of HCC oncogenesis. This paper aims to thoroughly detail the available information on the individual effects of capsaicin on the cellular mechanisms and pathways involved in HCC development, as well as investigate their possible cooperation and interferences. The synergistic antitumor effects of capsaicin and sorafenib are also addressed.<\/jats:p>","DOI":"10.3390\/molecules24132350","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T07:24:17Z","timestamp":1561533857000},"page":"2350","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-6393","authenticated-orcid":false,"given":"Cristian","family":"Scheau","sequence":"first","affiliation":[{"name":"Department of Physiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana Anca","family":"Badarau","sequence":"additional","affiliation":[{"name":"Department of Physiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-7965","authenticated-orcid":false,"given":"Constantin","family":"Caruntu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Dermatology, Prof. N.C. Paulescu National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gratiela Livia","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Physiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2915-5124","authenticated-orcid":false,"given":"Andreea Cristiana","family":"Didilescu","sequence":"additional","affiliation":[{"name":"Department of Embryology, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Constantin","sequence":"additional","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Neagu","sequence":"additional","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania"},{"name":"Faculty of Biology, University of Bucharest, 76201 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Adami, H.-O., Hunter, D.J., and Trichopoulos, D. 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