{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:37:41Z","timestamp":1789198661892,"version":"build-2803163510"},"reference-count":36,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T00:00:00Z","timestamp":1561852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473087"],"award-info":[{"award-number":["81473087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872752"],"award-info":[{"award-number":["81872752"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012591","name":"Program for Liaoning Innovative Talents in University","doi-asserted-by":"publisher","award":["LR2017043"],"award-info":[{"award-number":["LR2017043"]}],"id":[{"id":"10.13039\/501100012591","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University","award":["ZQN2016005"],"award-info":[{"award-number":["ZQN2016005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>To find novel human carbonic anhydrase (hCA) inhibitors, we synthesized thirteen compounds by combining thiazolidinone with benzenesulfonamide. The result of the X-ray single-crystal diffraction experiment confirmed the configuration of this class of compounds. The enzyme inhibition assays against hCA II and IX showed desirable potency profiles, as effective as the positive controls. The docking studies revealed that compounds (2) and (7) efficiently bound in the active site cavity of hCA IX by forming sufficient interactions with active site residues. The fragment of thiazolidinone played an important role in the binding of the molecules to the active site.<\/jats:p>","DOI":"10.3390\/molecules24132418","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T03:23:59Z","timestamp":1561951439000},"page":"2418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Synthesis, Molecular Docking Analysis, and Carbonic Anhydrase Inhibitory Evaluations of Benzenesulfonamide Derivatives Containing Thiazolidinone"],"prefix":"10.3390","volume":"24","author":[{"given":"Zuo-Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Fa","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-1944","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Sheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0021-9258(18)75831-6","article-title":"The catalytic of the hydration of carbon dioxide and dehydration of carbonic acid by an enzyme isolated from red blood cells","volume":"103","author":"Stadie","year":"1933","journal-title":"J. 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