{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:41:12Z","timestamp":1791416472436,"version":"4.3.3"},"reference-count":82,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>4-(4-Aminophenyl)-1-thia-4-azaspiro[4.5]decan-3-one 1 was prepared and allowed to react with nitrogen nucleophiles to give the corresponding hydrazones 2\u20134. Further, compound 1 underwent diazotization and afforded the parallel hydrazono derivative 5; moreover, compound 1 refluxed with active methylene derivatives yielded the corresponding aminospirothiazolo pyridine\u2013carbonitrile derivative 6 and spirothiazolopyridinone\u2013carbonitrile derivative 7. Condensation of spirothiazolidine 1 with 4-chlorobenzaldehyde gave the corresponding spiro arylidiene derivative 8, which was utilized as a component of Micheal addition to react with excess of nitrogen nucleophiles to yield novel ring frameworks 4-(3\u2032-(4-chlorophenyl)\u2013spiro [cyclohexane-1,5\u2032-pyrazolo[3,4-d]thiazol]-6\u2032(1\u2032H)-yl)aniline (9) and 4-(3\u2032-(4-chlorophenyl)-6\u2032H- spiro[cyclohexane-1,5\u2032-thiazolo[5,4-d]isoxazol]-6\u2032-yl)aniline (10). Finally, when spirothiazolo pyridinone\u2013carbonitrile derivative 7 sodium salt generated in situ was reacted with different alkyl halides, it produced the corresponding N-derivatives 12\u201316. Three compounds, 6, 14, and 16, showed high significantly anticancer activities compared with Doxorubicin\u00ae (positive control) against human breast carcinoma (MCF-7) and human liver carcinoma (HepG-2) cell lines. On the other hand, compounds 6 and 9 showed higher therapeutic indices for both of alpha-amylase inhibitor and alpha-glucosidase inhibitor than the other tested compounds compared with the antidiabetic Acarbose (positive control).<\/jats:p>","DOI":"10.3390\/molecules24132511","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T03:05:26Z","timestamp":1562727926000},"page":"2511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Development of a Novel Series of Anticancer and Antidiabetic: Spirothiazolidines Analogs"],"prefix":"10.3390","volume":"24","author":[{"given":"Eman M.","family":"Flefel","sequence":"first","affiliation":[{"name":"Department of Photochemistry, Chemical Industries Research Division, National Research Centre, 33 EL-Bohouth St., Dokki 12622, Giza, Egypt"},{"name":"Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Monawarah 1343, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa I.","family":"El-Sofany","sequence":"additional","affiliation":[{"name":"Department of Photochemistry, Chemical Industries Research Division, National Research Centre, 33 EL-Bohouth St., Dokki 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem A.K.","family":"Al-Harbi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Monawarah 1343, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"El-Shahat","sequence":"additional","affiliation":[{"name":"Department of Photochemistry, Chemical Industries Research Division, National Research Centre, 33 EL-Bohouth St., Dokki 12622, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"key":"ref_1","unstructured":"(2017, December 11). 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