{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:34:11Z","timestamp":1780317251297,"version":"3.54.1"},"reference-count":35,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T00:00:00Z","timestamp":1563667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["Y2008B17"],"award-info":[{"award-number":["Y2008B17"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270082"],"award-info":[{"award-number":["31270082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Three new \u03b3-hydroxyl butenolides (1\u20133), a pair of new enantiomeric spiro-butenolides (4a and 4b), a pair of enantiomeric cyclopentenones (5a new and 5b new natural), and six known compounds (6\u201311), were isolated from Aspergillus sclerotiorum. Their structures were established by spectroscopic data and electronic circular dichroism (ECD) spectra. Two pairs of enantiomers [(+)\/(\u2013)-6c and (+)\/(\u2013)-6d] obtained from the reaction of 6 with acetyl chloride (AcCl) confirmed that 6 was a mixture of two pairs of enantiomers. In addition, the X-ray data confirmed that 7 was also a racemate. The new metabolites (1\u22125) were evaluated for their inhibitory activity against cancer and non-cancer cell lines. As a result, compound 1 exhibited moderate cytotoxicity to HL60 and A549 with IC50 values of 6.5 and 8.9 \u00b5M, respectively, and weak potency to HL-7702 with IC50 values of 17.6 \u00b5M. Furthermore, compounds 1\u22129 were screened for their antimicrobial activity using the micro-broth dilution method. MIC values of 200 \u03bcg\/mL were obtained for compounds 2 and 3 towards Staphylococcus aureus and Escherichia coli, while compound 8 exhibited a MIC of 50 \u03bc\/mL towards Candida albicans.<\/jats:p>","DOI":"10.3390\/molecules24142642","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T02:55:37Z","timestamp":1563764137000},"page":"2642","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["New Butenolides and Cyclopentenones from Saline Soil-Derived Fungus Aspergillus Sclerotiorum"],"prefix":"10.3390","volume":"24","author":[{"given":"Li-Ying","family":"Ma","sequence":"first","affiliation":[{"name":"College of Pharmacy, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hui","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Jia","family":"Zhong","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Key Laboratory of Flavor Chemistry, Beijing Laboratory for Food Quality and Safety, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-7793","authenticated-orcid":false,"given":"Wei-Zhong","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,21]]},"reference":[{"key":"ref_1","first-page":"13","article-title":"The cytotoxics secondary metabolites from South China Sea derived fungus Aspergillus sclertoiorum XJW-56","volume":"33","author":"Xu","year":"2014","journal-title":"Chin. 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