{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:19Z","timestamp":1787029039627,"version":"build-2736575974"},"reference-count":84,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PNII-RU-TE-2014-4-1247"],"award-info":[{"award-number":["PNII-RU-TE-2014-4-1247"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Solidago species are often used in traditional medicine as anti-inflammatory, diuretic, wound-healing and antimicrobial agents. Still, the bioactive compounds and biological activities of some species have not been studied. The present work aimed to investigate the polyphenolic profile and the biological properties of Solidago graminifolia L. Salisb., a poorly explored medicinal plant. The hydroalcoholic extracts from aerial parts were evaluated for total phenolic content (TPC), total flavonoid content (TFC) and the polyphenolic compounds were investigated by HPLC-MS. The antioxidant potential in vitro was determined using DPPH and FRAP assays. Antibacterial and antifungal effects were evaluated by dilution assays and MIC, MBC and MFC were calculated. The results showed that Solidago graminifolia aerial parts contain an important amount of total phenolics (192.69 mg GAE\/g) and flavonoids (151.41 mg RE\/g), with chlorogenic acid and quercitrin as major constituents. The hydroalcoholic extracts showed promising antioxidant and antimicrobial potential, with potent antibacterial activity against Staphylococcus aureus and important antifungal effect against Candida albicans and C. parapsilosis. The obtained results indicated that the aerial parts of Solidago graminifolia could be used as novel resource of phytochemicals in herbal preparations with antioxidant and antimicrobial activities.<\/jats:p>","DOI":"10.3390\/molecules24142666","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T10:44:51Z","timestamp":1563878691000},"page":"2666","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Solidago graminifolia L. Salisb. (Asteraceae) as a Valuable Source of Bioactive Polyphenols: HPLC Profile, In Vitro Antioxidant and Antimicrobial Potential"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-4600","authenticated-orcid":false,"given":"Anca","family":"Toiu","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0664-3387","authenticated-orcid":false,"given":"Laurian","family":"Vlase","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Biopharmacy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5407-8071","authenticated-orcid":false,"given":"Dan Cristian","family":"Vodnar","sequence":"additional","affiliation":[{"name":"Department of Food Science, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-0777","authenticated-orcid":false,"given":"Ana-Maria","family":"Gheldiu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-9993","authenticated-orcid":false,"given":"Ilioara","family":"Oniga","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbdv.201800023","article-title":"Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba\u2014Goldenrod","volume":"15","author":"Wozniak","year":"2018","journal-title":"Chem. Biodivers."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jep.2007.07.003","article-title":"Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleuresy","volume":"113","author":"Goulart","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1080\/13880209.2016.1190381","article-title":"In vivo anti-inflammatory activity of caffeoylquinic acid derivatives from Solidago virgaurea in rats","volume":"54","author":"Motaal","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.phytochem.2012.10.004","article-title":"Triterpenoid saponins from the aerial parts of Solidago virgaurea alpestris with inhibiting activity of Candida albicans yeast-hyphal conversion","volume":"86","author":"Sarrazin","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.phytochem.2009.09.032","article-title":"Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)","volume":"71","author":"Starks","year":"2010","journal-title":"Phytochemistry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ffj.1271","article-title":"Constituents of the essential oils of four micropropagated Solidago species","volume":"19","author":"Kalemba","year":"2004","journal-title":"Flavour Fragr. J."},{"key":"ref_7","first-page":"274","article-title":"Antioxidant and antimicrobial activities of Solidago virgaurea extracts","volume":"8","author":"Demir","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.18388\/abp.2001_5125","article-title":"The flavonoids, quercetin and isorhamnetin 3-O-acylglucosides diminish neutrophil oxidative metabolism and lipid peroxidation","volume":"48","author":"Kostrzewa","year":"2001","journal-title":"Acta Biochim. Pol."},{"key":"ref_9","first-page":"6770","article-title":"Antibacterial and antimutagenic activity of extracts aboveground parts of three Solidago species: Solidago virgaurea L.; Solidago canadensis L. and Solidago gigantea Ait","volume":"5","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_10","first-page":"165","article-title":"Anti-inflammatory, spasmolytic and diuretic effects of a commercially available Solidago gigantea Herb. extract","volume":"45","author":"Leuschner","year":"1995","journal-title":"Arzneimittelforschung"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1211\/jpp.60.4.0015","article-title":"The anti-inflammatory modulatory role of Solidago chilensis Meyen in the murine model of the air pouch","volume":"60","author":"Liz","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/16546628.2016.1273479","article-title":"Anti-obesity effect of Solidago virgaurea var. gigantea extract through regulation of adipogenesis and lipogenesis pathways in high-fat diet-induced obese mice (C57BL\/6N)","volume":"61","author":"Wang","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Jang, Y.S., Wang, Z., Lee, J.M., Lee, J.Y., and Lim, S.S. (2016). Screening of Korean natural products for anti-adipogenesis properties and isolation of kaempferol-3-o-rutinoside as a potent anti-adipogenetic compound from Solidago virgaurea. Molecules, 21.","DOI":"10.3390\/molecules21020226"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1207\/S15327914NC431_9","article-title":"Antineoplastic activity of Solidago virgaurea on prostatic tumor cells in an SCID mouse model","volume":"43","author":"Gross","year":"2002","journal-title":"Nutr. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/BF02975338","article-title":"Cytotoxic Constituents from Solidago virga-aurea var, gigantea MIQ","volume":"22","author":"Sung","year":"1999","journal-title":"Arch. Pharm. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00210-015-1208-0","article-title":"Pharmacological reports about gastroprotective effects of methanolic extract from leaves of Solidago chilensis (Brazilian arnica) and its components quercitrin and afzelin in rodents","volume":"389","author":"Boeing","year":"2016","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3109\/13880200903453131","article-title":"Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)","volume":"48","author":"Bucciarelli","year":"2010","journal-title":"Pharm. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0378-8741(02)00054-5","article-title":"Gastroprotective activity of the diterpene solidagenone and its derivatives on experimentally induced gastric lesions in mice","volume":"81","author":"Rodriguez","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","first-page":"20","article-title":"The urological effect of leiocarposides","volume":"12","author":"Budzianowski","year":"1999","journal-title":"Drog. Rep."},{"key":"ref_20","first-page":"181","article-title":"Effect of leiocarposide on experimental urinary calculi in rats","volume":"45","author":"Chodera","year":"1988","journal-title":"Acta Pol. Pharm."},{"key":"ref_21","first-page":"35","article-title":"Effect of flavonoid fractions of Solidago virgaurea L on diuresis and levels of electrolytes","volume":"48","author":"Chodera","year":"1991","journal-title":"Acta Pol. Pharm."},{"key":"ref_22","first-page":"333","article-title":"Study of the anti-inflammatory activity of Populus tremula, Solidago virgaurea and Fraxinus excelsior","volume":"42","author":"Khayyal","year":"1992","journal-title":"Arzneimittelforschung"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jep.2009.01.029","article-title":"Inhibitory effects of Solidago chilensis Meyen hydroalcoholic extract on acute inflammation","volume":"122","author":"Tamura","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","first-page":"869","article-title":"Antiphlogistic and analgesic effects of leiocarposide, a phenolic bisglucoside of Solidago virgaurea L.","volume":"39","author":"Metzner","year":"1984","journal-title":"Pharmazie"},{"key":"ref_25","first-page":"251","article-title":"In-vitro effect of flavonoids from Solidago canadensis extract on glutathione S-transferase","volume":"58","author":"Houghton","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1016\/j.bmc.2004.08.048","article-title":"New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta","volume":"12","author":"Chaturvedula","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"ref_27","first-page":"953","article-title":"Immunomodulatory and antitumoral effects of triterpenoid saponins","volume":"52","author":"Plohmann","year":"1997","journal-title":"Pharmazie"},{"key":"ref_28","first-page":"72","article-title":"Cytotoxicity of triterpenoid saponins. Part 2. Relationships between the structures of glycosides of polygalacic acid and their activities against pathogenic Candida species","volume":"55","author":"Bader","year":"2000","journal-title":"Pharmazie"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00345-002-0293-0","article-title":"Botanical medicines for the urinary tract","volume":"20","author":"Yarnell","year":"2002","journal-title":"Artic. World J. Urol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00345-013-1173-5","article-title":"Solidago, orthosiphon, birch and cranberry extracts can decrease microbial colonization and biofilm development in indwelling urinary catheter: A microbiologic and ultrastructural pilot study","volume":"32","author":"Cai","year":"2014","journal-title":"World J. Urol."},{"key":"ref_31","first-page":"67","article-title":"European goldenrod as anti-inflammatory drug","volume":"21","author":"Melzig","year":"2000","journal-title":"Z. F\u00fcr Phyther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Vuolo, M.M., Lima, V.S., and Junior, M.R.M. (2019). Chapter 2\u2014Phenolic Compounds: Structure, Classification, and Antioxidant Power. Bioactive Compounds, Elsevier Inc.","DOI":"10.1016\/B978-0-12-814774-0.00002-5"},{"key":"ref_33","first-page":"174","article-title":"Antioxidative properties of alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea","volume":"45","author":"Meyer","year":"1995","journal-title":"Arzneimittelforschung"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00210-004-0869-x","article-title":"Extracts from Rhois aromatica and Solidaginis virgaurea inhibit rat and human bladder contraction","volume":"369","author":"Borchert","year":"2004","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(93)90968-N","article-title":"Vasodilator effects of quercetin in isolated rat vascular smooth muscle","volume":"239","author":"Duarte","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0306-3623(93)90159-U","article-title":"Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships","volume":"24","author":"Duarte","year":"1993","journal-title":"Gen. Pharmacol."},{"key":"ref_37","first-page":"27","article-title":"The antimicrobial activity of Solidago-containing phytourologica","volume":"12","author":"Brantner","year":"1999","journal-title":"Drog. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0367-326X(02)00180-6","article-title":"Antimicrobial activity of Solidago virgaurea L. from in vitro cultures","volume":"73","author":"Thiem","year":"2002","journal-title":"Fitoterapia"},{"key":"ref_39","first-page":"618","article-title":"Antifungal action of glycosides of polygalacic acid","volume":"45","author":"Bader","year":"1990","journal-title":"Pharmazie"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02975135","article-title":"Immunobiological [correction of Immunobioloical] activity of a new benzyl benzoate from the aerial parts of Solidago virga-aurea var. gigantea","volume":"28","author":"Choi","year":"2005","journal-title":"Arch. Pharm. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s13105-013-0277-0","article-title":"Biochemical effects of Solidago virgaurea extract on experimental cardiotoxicity","volume":"70","year":"2014","journal-title":"J. Physiol. Biochem."},{"key":"ref_42","unstructured":"Tokarska-Guzik, B., Brock, J., Brundu, G., Child, L., Daehler, C., and Pysek, P. (2008). Solidago graminifolia (L.) Elliott in Poland-spreading and habitat preferences. Plant Invasions: Human Perception, Ecological Impacts and Management, Backhuys Publishers."},{"key":"ref_43","unstructured":"Tutin, T.G., Heywood, V.H., Burges, N.A., Moore, D.M., Valentine, D.H., Walters, S.M., and Webb, D.A. (2010). Flora Europaea, Cambridge University Press. [7th ed.]."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1016\/0031-9422(92)80433-F","article-title":"Acetylenes from the roots of Solidago species","volume":"31","author":"Lam","year":"1992","journal-title":"Phytochemistry"},{"key":"ref_45","first-page":"413","article-title":"Two di-C-glycosylflavones from Solidago graminifolia","volume":"58","author":"Budzianowski","year":"1990","journal-title":"Sci. Pharm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ffj.2730090514","article-title":"Constituents of the essential oil of Solidago graminifolia (L.) salisb","volume":"9","author":"Kalemba","year":"1994","journal-title":"Flavour Fragr. J."},{"key":"ref_47","first-page":"277","article-title":"Phenolic compounds in two Solidago, L. species from in vitro culture","volume":"58","author":"Thiem","year":"2001","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00436-008-1277-9","article-title":"Plant extracts as natural amoebicidal agents","volume":"104","author":"Derda","year":"2009","journal-title":"Parasitol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu9050455","article-title":"A critical review on polyphenols and health benefits of black soybeans","volume":"9","author":"Ganesan","year":"2017","journal-title":"Nutrients"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Brglez Mojzer, E., Knez Hrn\u010di\u010d, M., \u0160kerget, M., Knez, \u017d., and Bren, U. (2016). Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects. Molecules, 21.","DOI":"10.3390\/molecules21070901"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","article-title":"Plant polyphenols as dietary antioxidants in human health and disease","volume":"2","author":"Pandey","year":"2009","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1111\/j.1365-2621.2009.02077.x","article-title":"Polyphenols: Food sources, properties and applications\u2014A review","volume":"44","year":"2009","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_54","first-page":"463","article-title":"Effect of solvent type and extraction conditions on the recovery of Phenolic compounds from artichoke waste","volume":"39","author":"Zuorro","year":"2014","journal-title":"Chem. Eng. Trans."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.apjtm.2016.03.029","article-title":"Antioxidant and hepatoprotective effects of Ajuga nipponensis extract by ultrasonic-assisted extraction","volume":"9","author":"Hsieh","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Xu, D.P., Li, Y., Meng, X., Zhou, T., Zhou, Y., Zheng, J., Zhang, J.J., and Li, H. (2017). Bin Natural antioxidants in foods and medicinal plants: Extraction, assessment and resources. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010096"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1750-3841.2012.02804.x","article-title":"Study of Optimal Extraction Conditions for Achieving High Yield and Antioxidant Activity of Tomato Seed Oil","volume":"77","author":"Shao","year":"2012","journal-title":"J. Food Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biopha.2017.10.064","article-title":"Chlorogenic acid (CGA): A pharmacological review and call for further research","volume":"97","author":"Naveed","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2174\/1570159X14666160325120625","article-title":"Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine","volume":"15","author":"Nabavi","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Santana-G\u00e1lvez, J., Cisneros-Zevallos, L., and Jacobo-Vel\u00e1zquez, D.A. (2017). Chlorogenic Acid: Recent advances on its dual role as a food additive and a nutraceutical against metabolic syndrome. Molecules, 22.","DOI":"10.3390\/molecules22030358"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/480258","article-title":"Antiartherosclerotic Effects of Plant Flavonoids","volume":"2014","author":"Salvamani","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.fitote.2015.09.018","article-title":"Quercetin: A flavonol with multifaceted therapeutic applications?","volume":"106","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s11064-008-9861-z","article-title":"Antioxidant effects of different extracts from melissa officinalis, matricaria recutita and cymbopogon citratus","volume":"34","author":"Pereira","year":"2009","journal-title":"Neurochem. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.3390\/molecules15064324","article-title":"Antioxidant activities, total phenolics and flavonoids content in two varieties of malaysia young ginger (Zingiber officinale Roscoe)","volume":"15","author":"Ghasemzadeh","year":"2010","journal-title":"Molecules"},{"key":"ref_65","first-page":"1","article-title":"Chemistry and Biological Activities of Flavonoids: An Overview","volume":"162750","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1271\/bbb.120562","article-title":"Separation of the Antioxidant Compound Quercitrin from Lindera obtusiloba Blume and Its Antimelanogenic Effect on B16F10 Melanoma Cells","volume":"77","author":"Hong","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.3390\/molecules18022376","article-title":"Free radical scavenging activity of Kielmeyera variabilis (Clusiaceae)","volume":"18","author":"Coqueiro","year":"2013","journal-title":"Molecules"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1078\/0944-7113-00327","article-title":"Antimicrobial activity in methanolic extracts of several plant species from northern Argentina","volume":"11","author":"Salvat","year":"2004","journal-title":"Phytomedicine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/jam.12196","article-title":"Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies","volume":"115","author":"Alves","year":"2013","journal-title":"J. Appl. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1002\/jsfa.6156","article-title":"In situ antioxidant and antimicrobial activities of naturally occurring caffeic acid, p-coumaric acid and rutin, using food systems","volume":"93","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.lwt.2015.08.024","article-title":"5-O-Caffeoylquinic acid: A spectroscopic study and biological screening for antimicrobial activity","volume":"65","author":"Bajko","year":"2016","journal-title":"LWT Food Sci. Technol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.3748\/wjg.v21.i21.6499","article-title":"Role of dietary polyphenols in the management of peptic ulcer","volume":"21","author":"Farzaei","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_73","first-page":"187","article-title":"Chemical composition and antimicrobial activity of solidago canadensis linn. Root essential oil","volume":"1","author":"Mishra","year":"2010","journal-title":"J. Basic Clin. Pharm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.fitote.2006.05.006","article-title":"Antimicrobial activity of extractives of Solidago microglossa","volume":"77","author":"Morel","year":"2006","journal-title":"Fitoterapia"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jep.2007.09.014","article-title":"Antifungal activity of medicinal plant extracts; preliminary screening studies","volume":"115","author":"Webster","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11655-016-2524-z","article-title":"Antifungal effect of plant extract and essential oil","volume":"23","author":"Uma","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pestbp.2017.05.012","article-title":"Chlorogenic acid is a fungicide active against phytopathogenic fungi","volume":"140","author":"Regente","year":"2017","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2018.00286","article-title":"Promising Antifungal Targets Against Candida albicans Based on Ion Homeostasis","volume":"8","author":"Li","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1351\/PAC-CON-09-01-08","article-title":"Antifungal action of chlorogenic acid against pathogenic fungi, mediated by membrane disruption","volume":"82","author":"Sung","year":"2010","journal-title":"Pure Appl. Chem."},{"key":"ref_80","first-page":"85","article-title":"Investigation of the antimycotic activity of Solidago virgaurea and Solidago gigantea extracts","volume":"8","author":"Pepeljnjak","year":"1998","journal-title":"Pharm. Pharmacol. Lett."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1055\/s-2002-20253","article-title":"Composition and antifungal activity of the essential oil of Solidago chilensis","volume":"68","author":"Vila","year":"2002","journal-title":"Planta Med."},{"key":"ref_82","first-page":"119","article-title":"Quantitative determination of total polyphenols and flavonoids from indigenous species of Epilobium of wild origin and \u201cin vitro\u201d regenerated plantlets","volume":"44","author":"Toiu","year":"2009","journal-title":"Contrib. Bot."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.00007","article-title":"Phytochemical composition, antioxidant, antimicrobial and in vivo anti-inflammatory activity of traditionally used Romanian Ajuga laxmannii (Murray) Benth. (\u201cnobleman\u2019s beard\u201d-barba \u00eemp\u0103ratului)","volume":"9","author":"Toiu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Toiu, A., Mocan, A., Vlase, L., P\u00e2rvu, A.E., Vodnar, D.C., Gheldiu, A.-M., Moldovan, C., Oniga, I., Toiu, A., and Mocan, A. (2019). Comparative Phytochemical Profile, Antioxidant, Antimicrobial and In Vivo Anti-Inflammatory Activity of Different Extracts of Traditionally Used Romanian Ajuga genevensis L. and A. reptans L. (Lamiaceae). 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