{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:32:51Z","timestamp":1783726371554,"version":"3.55.0"},"reference-count":93,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.<\/jats:p>","DOI":"10.3390\/molecules24152806","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T11:39:37Z","timestamp":1564659577000},"page":"2806","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-0420","authenticated-orcid":false,"given":"Johny Wysllas de Freitas","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunoparasitologia, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Alexandre Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy Marina Toscano Queiroz","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunoparasitologia, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Sousa","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunoparasitologia, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil"},{"name":"Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1800-166 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jlac.18500730103","article-title":"Ueber die verbindungen der sulfocarbamins\u00e4ure","volume":"73","author":"Debus","year":"1850","journal-title":"Justus Liebigs Ann. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0306-9877(88)90084-9","article-title":"Optimal dithiocarbamate structure for immunomodulator action","volume":"27","author":"Topping","year":"1988","journal-title":"Med. Hypotheses"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ejmech.2017.11.047","article-title":"Development of novel anti-filarial agents using carbamo (dithioperoxo) thioate derivatives","volume":"143","author":"Gucchait","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2174\/138955712802762040","article-title":"Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells","volume":"12","author":"Buac","year":"2012","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_5","first-page":"809","article-title":"Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells","volume":"19","author":"Pang","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1021\/la001269z","article-title":"Surface-enhanced vibrational study (SEIR and SERS) of dithiocarbamate pesticides on gold films","volume":"17","author":"Domingo","year":"2001","journal-title":"Langmuir"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.5271\/sjweh.1394","article-title":"Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate)","volume":"20","author":"Meco","year":"1994","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1107\/S0365110X65003985","article-title":"Structural studies of metal dithiocarbamates. I. The crystal and molecular structure of the \u03b1-form of nickel diethyldithiocarbamate","volume":"19","author":"Bonamico","year":"1965","journal-title":"Acta Crystallogr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1107\/S0365110X65004619","article-title":"Structural studies of metal dithiocarbamates. II. The crystal and molecular structure of copper diethyldithiocarbamate","volume":"19","author":"Bonamico","year":"1965","journal-title":"Acta Crystallogr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1107\/S0365110X65004620","article-title":"Structural studies of metal dithiocarbamates. III. The crystal and molecular structure of zinc diethyldithiocarbamate","volume":"19","author":"Bonamico","year":"1965","journal-title":"Acta Crystallogr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/0471725587.ch2","article-title":"Transition metal dithiocarbamates: 1978\u20132003","volume":"Volume 53","author":"Kenneth","year":"2005","journal-title":"Progress in Inorganic Chemistry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0010-8545(84)85017-1","article-title":"Electrochemistry and redox behaviour of transition metal dithiocarbamates","volume":"54","author":"Bond","year":"1984","journal-title":"Coord. Chem. Rev."},{"key":"ref_13","first-page":"233","article-title":"The chemistry of the dithioacid and 1, 1-dithiolate complexes","volume":"11","author":"Coucouvanis","year":"1970","journal-title":"Prog. Inorg. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1021\/op200131n","article-title":"Fit-for-purpose development of the enabling route to crizotinib (PF-02341066)","volume":"15","author":"McAndrew","year":"2011","journal-title":"Org. Proc. Res. Dev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chroma.2008.11.021","article-title":"Drug interactions with potential rubber closure extractables: Identification of thiol\u2013disulfide exchange reaction products of captopril and thiurams","volume":"1216","author":"Corredor","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471725587.ch1","article-title":"Main group dithiocarbamate complexes","volume":"Volume 53","author":"Kenneth","year":"2005","journal-title":"Progress in Inorganic Chemistry"},{"key":"ref_17","first-page":"10","article-title":"The role of Organic Dithiocarbamates in Drug Discovery Research","volume":"5","author":"Chaturvedi","year":"2016","journal-title":"Res. Rev. J. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.arabjc.2013.04.026","article-title":"Dithiocarbamates as hazardous remediation agent: A critical review on progress in environmental chemistry for inorganic species studies of 20th century","volume":"7","author":"Kanchi","year":"2014","journal-title":"Arab. J. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(17)31612-4","article-title":"Chagas disease","volume":"391","author":"Molina","year":"2018","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.mib.2009.06.011","article-title":"Fighting the oxidative assault: The Trypanosoma cruzi journey to infection","volume":"12","author":"Piacenza","year":"2009","journal-title":"Cur. Opin. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ahj.2008.08.024","article-title":"Prognostic impact of Chagas disease in the United States","volume":"157","author":"Milei","year":"2009","journal-title":"Am. Heart J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1590\/S0037-86822010000200004","article-title":"Analysis on the food source of Panstrongylus megistus (Hemiptera, Reduviidae, Triatominae) and its present importance as a vector for Trypanosoma cruzi, in the State of Minas Gerais","volume":"43","author":"Villela","year":"2010","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1191\/0960327106het653oa","article-title":"Toxic side effects of drugs used to treat Chagas\u2019 disease (American trypanosomiasis)","volume":"25","author":"Castro","year":"2006","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0166-6851(88)90093-X","article-title":"Chemiluminescence enhancement by trypanocidal drugs and by inhibitors of antioxidant enzymes in Trypanosoma cruzi","volume":"30","author":"Giulivi","year":"1988","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0162-0134(95)00027-5","article-title":"Chelating agent inhibition of Trypanosoma cruzi epimastigotes in vitro","volume":"60","author":"Rodrigues","year":"1995","journal-title":"J. Inorg. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/14756366.2014.913587","article-title":"Recent advances in the discovery of zinc-binding motifs for the development of carbonic anhydrase inhibitors","volume":"30","author":"Winum","year":"2015","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1016\/j.bmc.2013.05.058","article-title":"Anion inhibition studies of the \u03b1-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease","volume":"21","author":"Pan","year":"2013","journal-title":"Bioorganic. Med. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fphar.2016.00107","article-title":"Cysteine proteases: Modes of activation and future prospects as pharmacological targets","volume":"7","author":"Verma","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0169-4758(90)90189-B","article-title":"Cysteine proteinases of parasitic protozoa","volume":"6","author":"North","year":"1990","journal-title":"Parasitol. Today"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000239040","article-title":"Activity assays of thiadiazine derivatives on Trichomonas vaginalis and amastigote forms of Trypanosoma cruzi","volume":"38","author":"Atienza","year":"1992","journal-title":"Chemotherapy"},{"key":"ref_31","first-page":"764","article-title":"Synthesis and antiprotozoan properties of new 3, 5\u2014Disubstituted -tetrahydro-2H-1, 3, 5-thiadiazine-2-thione derivatives","volume":"49","author":"Ochoa","year":"1999","journal-title":"Arzneimittelforschung"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/ardp.19923250811","article-title":"Synthesis and Antiprotozoal Properties of 1, 2, 6-Thiadiazine 1, 1-Dioxide Derivatives","volume":"325","author":"Herrero","year":"1992","journal-title":"Arch. Pharm."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Houweling, T.A., Karim-Kos, H.E., Kulik, M.C., Stolk, W.A., Haagsma, J.A., Lenk, E.J., Richardus, J.H., and de Vlas, S.J. (2016). Socioeconomic inequalities in neglected tropical diseases: A systematic review. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004546"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1017\/S0031182016002523","article-title":"Chemotherapy of leishmaniasis: Present challenges","volume":"145","author":"Uliana","year":"2018","journal-title":"Parasitology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1128\/CMR.00061-07","article-title":"The relationship between leishmaniasis and AIDS: The second 10 years","volume":"21","author":"Alvar","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Lestinova, T., Rohousova, I., Sima, M., de Oliveira, C.I., and Volf, P. (2017). Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005600"},{"key":"ref_37","unstructured":"World Health Organization (2019). Leishmaniases: Epidemiological Report of the Americas. N\u00b0 7, World Health Organization."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.actatropica.2015.12.016","article-title":"Visceral leishmaniasis: Revisiting current treatments and approaches for future discoveries","volume":"155","author":"No","year":"2016","journal-title":"Acta Trop."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1017\/S0031182017002116","article-title":"Chemotherapeutics of visceral leishmaniasis: Present and future developments","volume":"145","author":"Sundar","year":"2018","journal-title":"Parasitology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.riam.2009.06.003","article-title":"Amphotericin B: Side effects and toxicity","volume":"26","year":"2009","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.2174\/156802611796575894","article-title":"Trypanocidal activity of nitroaromatic prodrugs: Current treatments and future perspectives","volume":"11","author":"Wilkinson","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1128\/AAC.01499-13","article-title":"Hepatotoxicity of pentavalent antimonial drug: Possible role of residual Sb (III) and protective effect of ascorbic acid","volume":"58","author":"Kato","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1128\/AAC.27.2.172","article-title":"Involvement of oxidative damage in erythrocyte lysis induced by amphotericin B","volume":"27","author":"Brajtburg","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_44","first-page":"75","article-title":"Osmiuminduced alteration in DNA-structure","volume":"3","author":"Jelen","year":"1984","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1021\/ac00223a002","article-title":"Electrochemical studies of the interaction of metal chelates with DNA. 4. Voltammetric and electrogenerated chemiluminescent studies of the interaction of tris (2, 2\u2019-bipyridine) osmium (II) with DNA","volume":"62","author":"Rodriguez","year":"1990","journal-title":"Anal. Chem."},{"key":"ref_46","first-page":"990","article-title":"In vitro activity and biochemical effectiveness of new organometallic complexes of osmium (III) against Leishmania donovani and Trypanosoma cruzi","volume":"46","author":"Castilla","year":"1996","journal-title":"Arzneimittel-Forschung"},{"key":"ref_47","first-page":"43","article-title":"Activity of Novel Tryptophan Analogs against Mammalian and Trypanosomal Monoamine Oxidases","volume":"6","author":"Markham","year":"2003","journal-title":"East Cent. Afr. J. Pharm. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Mugoyela, V.K., Hooper, M., Fairlamb, A.H., Mung\u2019ong\u2019o, S.G., and Croft, S. (2008). Activity of Novel Tryptophan Analogs against Trypanosoma cruzi and Leishmania donovani. East Cent. Afr. J. Pharm. Sci., 11.","DOI":"10.4314\/ecajps.v11i3.46283"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Khouri, R., Novais, F., Santana, G., de Oliveira, C.I., Vannier dos Santos, M.A., Barral, A., Barral-Netto, M., and Van Weyenbergh, J. (2010). DETC induces Leishmania parasite killing in human in vitro and murine in vivo models: A promising therapeutic alternative in Leishmaniasis. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0014394"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"38330","DOI":"10.1038\/srep38330","article-title":"DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis","volume":"6","author":"Celes","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1042\/bj20021684","article-title":"Role of superoxide dismutase in survival of Leishmania within the macrophage","volume":"369","author":"Ghosh","year":"2003","journal-title":"Biochem. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1128\/AAC.05146-14","article-title":"Identification of metal dithiocarbamates as a novel class of antileishmanial agents","volume":"59","author":"Pal","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.bmc.2017.01.034","article-title":"Carbonic anhydrases from Trypanosoma and Leishmania as anti-protozoan drug targets","volume":"25","author":"Vermelho","year":"2017","journal-title":"Bioorganic Med. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/14756366.2017.1414808","article-title":"Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles","volume":"33","author":"Nocentini","year":"2018","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1080\/14756366.2018.1463221","article-title":"Antileishmanial activity of sulphonamide nanoemulsions targeting the \u03b2-carbonic anhydrase from Leishmania species","volume":"33","author":"Vermelho","year":"2018","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Barrett, M.P. (2018). The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis. PLoS Negl. Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006925"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0924-8579(94)90012-4","article-title":"Drug used in the treatment of sleeping sickness (human African trypanosomiasis: HAT)","volume":"4","year":"1994","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/ardp.19602931102","article-title":"New compounds with bactericidal and fungicidal activity and which inhibit the growth of viruses. I. 2-thiotetrahydro-1, 3, 5-thiadiazine (\u201ccarbothialdine\u201d) and dithiocarbamic acid salts","volume":"293","author":"Rieche","year":"1960","journal-title":"Arch. Pharm. Ber. Dtsch. Pharm. Ges."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3891\/acta.chem.scand.18-1341","article-title":"Chemical and fungicidal reactions of 3, 5-dimethyltetrahydro-1, 3, 5-thiadiazine-2-thione (3, 5-D). A comparison with sodium N-methyl dithiocarbamate and methyl isothiocyanate","volume":"18","author":"Goksoyr","year":"1964","journal-title":"Acta Chem. Scand."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0223-5234(94)90120-1","article-title":"Model for delivery of amines through incorporation into a tetrahydro-2H-1, 3, 5-thiadiazine-2-thione structure","volume":"29","year":"1994","journal-title":"Eur. J. Med. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0223-5234(96)80450-8","article-title":"New prodrug approach for amino acids and amino-acid-like drugs","volume":"31","year":"1996","journal-title":"Eur. J. Med. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1874104501105010051","article-title":"Thiadiazine derivatives as antiprotozoal new drugs","volume":"5","author":"Bermello","year":"2011","journal-title":"Open Med. Chem. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.jinorgbio.2011.09.006","article-title":"Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro","volume":"105","author":"Micale","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10787-012-0149-1","article-title":"The biological activity of auranofin: Implications for novel treatment of diseases","volume":"20","author":"Madeira","year":"2012","journal-title":"Inflammopharmacology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10534-017-0007-0","article-title":"Gold compounds as cysteine protease inhibitors: Perspectives for pharmaceutical application as antiparasitic agents","volume":"30","author":"Massai","year":"2017","journal-title":"BioMetals"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/j.tetlet.2015.03.132","article-title":"Synthesis of substituted carbamo (dithioperoxo) thioates as potential BCA2-inhibitory anticancer agents","volume":"56","author":"Cilibrasi","year":"2015","journal-title":"Tetrahedron Lett."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1124\/jpet.111.185678","article-title":"Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation","volume":"339","author":"Song","year":"2011","journal-title":"J. Pharm. Exp. Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"110517","DOI":"10.1039\/C6RA19469A","article-title":"Monofunctional platinum (II) dithiocarbamate complexes: Synthesis, characterization and anticancer activity","volume":"6","author":"Amir","year":"2016","journal-title":"RSC Adv."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"490","DOI":"10.18632\/oncotarget.13448","article-title":"New bipyridine gold (III) dithiocarbamate-containing complexes exerted a potent anticancer activity against cisplatin-resistant cancer cells independent of p53 status","volume":"8","author":"Altaf","year":"2017","journal-title":"Oncotarget"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.intimp.2014.05.007","article-title":"In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs","volume":"21","author":"Kasai","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejmech.2015.11.044","article-title":"Synthesis and biological evaluation of quinazolin-4(3H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents","volume":"108","author":"Ding","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.poly.2013.03.056","article-title":"Design and synthesis of thalidomide based dithiocarbamate Cu (II), Ni (II) and Ru (III) complexes as anticancer agents","volume":"56","author":"Ali","year":"2013","journal-title":"Polyhedron"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"28756","DOI":"10.1039\/C4RA03655G","article-title":"C5-curcuminoid-dithiocarbamate based molecular hybrids: Synthesis and anti-inflammatory and anti-cancer activity evaluation","volume":"4","author":"Rawat","year":"2014","journal-title":"RSC Adv."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1039\/C5MD00042D","article-title":"Synthesis and biodistribution of novel 99m Tc labeled 4-nitroimidazole dithiocarbamate complexes as potential agents to target tumor hypoxia","volume":"6","author":"Li","year":"2015","journal-title":"Med. Chem. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.saa.2010.05.029","article-title":"Interaction studies between a 1, 10-phenanthroline adduct of palladium (II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study","volume":"77","author":"Saeidifar","year":"2010","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.1021\/jm401002r","article-title":"Triazole\u2013dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration","volume":"56","author":"Zheng","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1021\/ic4025926","article-title":"Phosphinogold (I) dithiocarbamate complexes: Effect of the nature of phosphine ligand on anticancer properties","volume":"53","author":"Keter","year":"2014","journal-title":"Inorg. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Cardona, P.J. (2012). The potential therapeutic usage of dithiocarbamate sugar derivatives for multi-drug resistant tuberculosis. Understanding Tuberculosis-New Approaches to Fighting Against Drug Resistance, IntechOpen.","DOI":"10.5772\/2477"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.bmcl.2010.12.084","article-title":"Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives","volume":"21","author":"Horita","year":"2011","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00430-010-0182-x","article-title":"Therapy of experimental influenza virus infection with pyrrolidine dithiocarbamate","volume":"200","author":"Wiesener","year":"2011","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1128\/JVI.00869-13","article-title":"Pyrrolidine dithiocarbamate inhibits herpes simplex virus 1 and 2 replication, and its activity may be mediated through dysregulation of the ubiquitin-proteasome system","volume":"87","author":"Qiu","year":"2013","journal-title":"J. Virol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2298\/JSC150114047L","article-title":"Facile synthesis and antifungal activity of dithiocarbamate derivatives bearing an amide moiety","volume":"80","author":"Li","year":"2015","journal-title":"J. Serb. Chem. Soc."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ica.2014.09.002","article-title":"Synthesis, characterization and antifungal activity of new dithiocarbamate-based complexes of Ni (II), Pd (II) and Pt (II)","volume":"423","author":"Ferreira","year":"2014","journal-title":"Inorg. Chem. Acta"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1016\/j.bmcl.2010.04.057","article-title":"Synthesis and biological evaluation of a novel 99mTc (CO) 3 complex of ciprofloxacin dithiocarbamate as a potential agent to target infection","volume":"20","author":"Zhang","year":"2010","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ejmech.2018.05.028","article-title":"Synthesis, cytotoxic evaluation and target identification of thieno [2, 3-d] pyrimidine derivatives with a dithiocarbamate side chain at C2 position","volume":"154","author":"Yang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.comptc.2014.08.027","article-title":"Theoretical study on the bifunctional substitution reactions between gold (III) dithiocarbamate derivative Au (DMDT) Cl2 (DMDT = N,N-dimethyldithiocarbamate) and target molecules","volume":"1048","author":"Liao","year":"2014","journal-title":"Comput. Theor. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1016\/j.bmcl.2016.07.012","article-title":"Design, synthesis and antiproliferative activity studies of novel dithiocarbamate\u2013chalcone derivates","volume":"26","author":"Fu","year":"2016","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3906\/kim-1312-62","article-title":"Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains","volume":"38","author":"Demirci","year":"2014","journal-title":"Turk. J. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1080\/10426507.2016.1150277","article-title":"Synthesis and antimicrobial activity evaluation of new dithiocarbamate derivatives bearing thiazole\/benzothiazole rings","volume":"191","author":"Yusuf","year":"2016","journal-title":"Phosphorus Sulfur Silicon Relat. Elem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejmech.2013.03.058","article-title":"Design, synthesis and antiproliferative activity studies of novel 1, 2, 3-triazole\u2013dithiocarbamate\u2013urea hybrids","volume":"64","author":"Duan","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cell.2013.09.018","article-title":"The dynamics of signaling as a pharmacological target","volume":"155","author":"Behar","year":"2013","journal-title":"Cell"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.bmcl.2010.01.081","article-title":"Carbonic anhydrase inhibitors. Inhibition of transmembrane isoforms IX, XII, and XIV with less investigated anions including trithiocarbonate and dithiocarbamate","volume":"20","author":"Innocenti","year":"2010","journal-title":"Bioorganic. Med. Chem. Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ica.2017.04.040","article-title":"Synthesis, characterization, in vitro cytotoxicity and DNA interaction study of phosphanegold (I) complexes with dithiocarbamate ligands","volume":"464","author":"Altaf","year":"2017","journal-title":"Inorg. Chem. Acta"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/15\/2806\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:12:10Z","timestamp":1760188330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/15\/2806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,1]]},"references-count":93,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2019,8]]}},"alternative-id":["molecules24152806"],"URL":"https:\/\/doi.org\/10.3390\/molecules24152806","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,1]]}}}