{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T01:11:03Z","timestamp":1773450663548,"version":"3.50.1"},"reference-count":195,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education of Singapore Tier 2 Research grant","award":["MOE2017-T2-2-029"],"award-info":[{"award-number":["MOE2017-T2-2-029"]}]},{"name":"Jiangsu Nature Science Foundation","award":["BK20181185"],"award-info":[{"award-number":["BK20181185"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Diabetic kidney disease develops in approximately 40% of diabetic patients and is a major cause of chronic kidney diseases (CKD) and end stage kidney disease (ESKD) worldwide. Hydrogen sulfide (H2S), the third gasotransmitter after nitric oxide (NO) and carbon monoxide (CO), is synthesized in nearly all organs, including the kidney. Though studies on H2S regulation of renal physiology and pathophysiology are still in its infancy, emerging evidence shows that H2S production by renal cells is reduced under disease states and H2S donors ameliorate kidney injury. Specifically, aberrant H2S level is implicated in various renal pathological conditions including diabetic nephropathy. This review presents the roles of H2S in diabetic renal disease and the underlying mechanisms for the protective effects of H2S against diabetic renal damage. H2S may serve as fundamental strategies to treat diabetic kidney disease. These H2S treatment modalities include precursors for H2S synthesis, H2S donors, and natural plant-derived compounds. Despite accumulating evidence from experimental studies suggests the potential role of the H2S signaling pathway in the treatment of diabetic nephropathy, these results need further clinical translation. Expanding understanding of H2S in the kidney may be vital to translate H2S to be a novel therapy for diabetic renal disease.<\/jats:p>","DOI":"10.3390\/molecules24152857","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T10:56:38Z","timestamp":1565175398000},"page":"2857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy"],"prefix":"10.3390","volume":"24","author":[{"given":"Hai-Jian","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Yuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng-Teng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Wei","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Song","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"National University of Singapore (Suzhou) Research Institute, Suzhou 215000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4239\/wjd.v5.i3.393","article-title":"Diabetic nephropathy and inflammation","volume":"5","year":"2014","journal-title":"World J. Diabetes"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12727","DOI":"10.3390\/molecules190812727","article-title":"Effect of redox modulating NRF2 activators on chronic kidney disease","volume":"19","author":"Choi","year":"2014","journal-title":"Molecules"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1089\/ars.2015.6596","article-title":"Hydrogen sulfide in renal physiology and disease","volume":"25","author":"Feliers","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1681\/ASN.2012070718","article-title":"Kidney disease and increased mortality risk in type 2 diabetes","volume":"24","author":"Afkarian","year":"2013","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1573399052952622","article-title":"Insight on the pathogenesis of diabetic nephropathy from the study of podocyte and mesangial cell biology","volume":"1","author":"Gruden","year":"2005","journal-title":"Curr. Diabetes Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pharep.2016.11.004","article-title":"Diabetic nephropathy: A potential savior with \u2018rotten-egg\u2019 smell","volume":"69","author":"Dugbartey","year":"2017","journal-title":"Pharmacol. Rep. PR"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bcp.2017.12.005","article-title":"Hydrogen sulfide as a regulatory factor in kidney health and disease","volume":"149","author":"Kasinath","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3389\/fphar.2016.00385","article-title":"The role of hydrogen sulfide in renal system","volume":"7","author":"Cao","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2018.02.030","article-title":"The role of hydrogen sulfide in health and disease","volume":"149","author":"Kashfi","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Cao, X., Zhang, W., Moore, P.K., and Bian, J. (2019). Protective smell of hydrogen sulfide and polysulfide in cisplatin-induced nephrotoxicity. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020313"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.niox.2015.01.005","article-title":"Hydrogen sulfide in renal physiology, disease and transplantation\u2014The smell of renal protection","volume":"46","author":"Koning","year":"2015","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.niox.2014.10.004","article-title":"Hydrogen sulphide and the kidney: Important roles in renal physiology and pathogenesis and treatment of kidney injury and disease","volume":"46","author":"Lobb","year":"2015","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: Challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol. CJASN"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jfma.2018.02.007","article-title":"Update of pathophysiology and management of diabetic kidney disease","volume":"117","author":"Lin","year":"2018","journal-title":"J. Formos. Med Assoc. Taiwan Yi Zhi"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2337\/dbi16-0056","article-title":"Back to the future: Glomerular hyperfiltration and the diabetic kidney","volume":"66","author":"Tuttle","year":"2017","journal-title":"Diabetes"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/092986709787002853","article-title":"Endothelial dysfunction in diabetes: From mechanisms to therapeutic targets","volume":"16","author":"Potenza","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1681\/ASN.2013080830","article-title":"The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy","volume":"25","author":"Coll","year":"2014","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.semnephrol.2004.04.005","article-title":"Role of nitric oxide in diabetic nephropathy","volume":"24","author":"Prabhakar","year":"2004","journal-title":"Semin. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/sj.ki.5000062","article-title":"Expression of hypoxia-inducible transcription factors in developing human and rat kidneys","volume":"69","author":"Bernhardt","year":"2006","journal-title":"Kidney Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tem.2005.02.003","article-title":"The renin-angiotensin-aldosterone system, glucose metabolism and diabetes","volume":"16","author":"Giacchetti","year":"2005","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"ref_21","first-page":"2526","article-title":"Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney","volume":"118","author":"Toma","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.semnephrol.2007.01.009","article-title":"The renin-angiotensin system and diabetic nephropathy","volume":"27","author":"Gurley","year":"2007","journal-title":"Semin. Nephrol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s10157-013-0781-0","article-title":"Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease","volume":"17","author":"He","year":"2013","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_24","first-page":"2302","article-title":"Aldosterone, a vasculotoxic agent\u2014Novel functions for an old hormone","volume":"24","author":"Ritz","year":"2009","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transplant. Assoc. Eur. Ren. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/157339908783502370","article-title":"Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy","volume":"4","author":"Ziyadeh","year":"2008","journal-title":"Curr. Diabetes Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1007\/s00125-016-4021-5","article-title":"JAK inhibition in the treatment of diabetic kidney disease","volume":"59","author":"Brosius","year":"2016","journal-title":"Diabetologia"},{"key":"ref_27","first-page":"1792","article-title":"Two\u2019s company, three\u2019s a crowd: Can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pharmthera.2009.05.005","article-title":"Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation\u2013A tale of three gases!","volume":"123","author":"Li","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"16633","DOI":"10.1073\/pnas.0902952106","article-title":"No facilitator required for membrane transport of hydrogen sulfide","volume":"106","author":"Mathai","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H(2)S signalling through protein sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"22457","DOI":"10.1074\/jbc.M109.010868","article-title":"Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions","volume":"284","author":"Singh","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"16146","DOI":"10.3390\/molecules191016146","article-title":"Hydrogen sulfide and polysulfides as biological mediators","volume":"19","author":"Kimura","year":"2014","journal-title":"Molecules"},{"key":"ref_33","first-page":"601","article-title":"Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics","volume":"27","author":"Modis","year":"2013","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/jb\/mvr018","article-title":"Production of H2S by 3-mercaptopyruvate sulphurtransferase","volume":"149","author":"Tanizawa","year":"2011","journal-title":"J. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/ars.2011.4005","article-title":"Hydrogen sulfide in the mammalian cardiovascular system","volume":"17","author":"Liu","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ncomms2371","article-title":"A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00726-004-0072-x","article-title":"Endogenous production of hydrogen sulfide in mammals","volume":"26","author":"Kamoun","year":"2004","journal-title":"Amino Acids"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/ki.2013.449","article-title":"Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy","volume":"85","author":"Song","year":"2014","journal-title":"Kidney Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"593407","DOI":"10.1155\/2015\/593407","article-title":"Hydrogen sulfide as a potential therapeutic target in fibrosis","volume":"2015","author":"Zhang","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1681\/ASN.2012030268","article-title":"Cystathionine gamma-lyase protects against renal ischemia\/reperfusion by modulating oxidative stress","volume":"24","author":"Bos","year":"2013","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1124\/jpet.108.149963","article-title":"Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys","volume":"329","author":"Xia","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/ars.2010.3781","article-title":"The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues","volume":"15","author":"Kabil","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/ars.2012.5024","article-title":"Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes","volume":"19","author":"Xue","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_45","first-page":"2119","article-title":"Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide","volume":"26","author":"Yuan","year":"2011","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transplant. Assoc. Eur. Ren. Assoc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1089\/ars.2009.2956","article-title":"Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation?","volume":"12","author":"Jain","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1007\/s00125-010-1761-5","article-title":"Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide","volume":"53","author":"Whiteman","year":"2010","journal-title":"Diabetologia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000368883","article-title":"Correlation of lower concentrations of hydrogen sulfide with atherosclerosis in chronic hemodialysis patients with diabetic nephropathy","volume":"38","author":"Li","year":"2014","journal-title":"Blood Purif."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.1074\/jbc.M116.766758","article-title":"Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells","volume":"292","author":"Lee","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"28827","DOI":"10.1074\/jbc.M114.596593","article-title":"Hydrogen sulfide alleviates diabetic nephropathy in a streptozotocin-induced diabetic rat model","volume":"289","author":"Zhou","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1089\/ars.2013.5304","article-title":"Hydrogen sulfide targets EGFR Cys797\/Cys798 residues to induce Na (+)\/K (+)-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats","volume":"21","author":"Ge","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zhang, J., Chen, S., Liu, H., Zhang, B., Zhao, Y., Ma, K., Zhao, D., Wang, Q., Ma, H., and Zhang, Z. (2013). Hydrogen sulfide prevents hydrogen peroxide-induced activation of epithelial sodium channel through a PTEN\/PI (3,4,5)P3 dependent pathway. PLoS ONE, 8.","DOI":"10.1371\/annotation\/1cc3a25b-dc35-4d2a-8465-b11916f2e863"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"R636","DOI":"10.1152\/ajpregu.00489.2014","article-title":"Hydrogen sulfide decreases beta-adrenergic agonist-stimulated lung liquid clearance by inhibiting ENaC-mediated transepithelial sodium absorption","volume":"308","author":"Agne","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"C866","DOI":"10.1152\/ajpcell.00105.2010","article-title":"Bicarbonate-dependent effect of hydrogen sulfide on vascular contractility in rat aortic rings","volume":"299","author":"Liu","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.bbrc.2007.04.203","article-title":"Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins","volume":"358","author":"Lee","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/ars.2014.5930","article-title":"Hydrogen sulfide as an oxygen sensor","volume":"22","author":"Olson","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/cphy.c100069","article-title":"Peripheral chemoreceptors: Function and plasticity of the carotid body","volume":"2","author":"Kumar","year":"2012","journal-title":"Compr. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1242\/jeb.02480","article-title":"Hydrogen sulfide as an oxygen sensor\/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation","volume":"209","author":"Olson","year":"2006","journal-title":"J. Exp. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1089\/ars.2009.2921","article-title":"Hydrogen sulfide and oxygen sensing in the cardiovascular system","volume":"12","author":"Olson","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.neuroscience.2008.08.025","article-title":"Endogenous hydrogen sulfide is involved in regulation of respiration in medullary slice of neonatal rats","volume":"156","author":"Hu","year":"2008","journal-title":"Neuroscience"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1242\/jeb.061473","article-title":"Hydrogen sulfide (H2S) and hypoxia inhibit salmonid gastrointestinal motility: Evidence for H2S as an oxygen sensor","volume":"214","author":"Dombkowski","year":"2011","journal-title":"J. Exp. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fphys.2017.00099","article-title":"Renal hypoxia in CKD; Pathophysiology and detecting methods","volume":"8","author":"Hirakawa","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"12679","DOI":"10.1073\/pnas.1308487110","article-title":"Oxygen-sensitive mitochondrial accumulation of cystathionine beta-synthase mediated by Lon protease","volume":"110","author":"Teng","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1073\/pnas.1115634109","article-title":"Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production","volume":"109","author":"Fu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/jpet.110.166637","article-title":"Hypoxia in the renal medulla: Implications for hydrogen sulfide signaling","volume":"334","author":"Beltowski","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00424-017-2008-9","article-title":"Endocrine functions of the renal interstitium","volume":"469","author":"Kurtz","year":"2017","journal-title":"Pflug. Arch. Eur. J. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2215\/CJN.00640114","article-title":"Physiology of the renal interstitium","volume":"10","author":"Zeisberg","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol. CJASN"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2215\/CJN.04650417","article-title":"Diabetic kidney disease","volume":"13","author":"Tong","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol. CJASN"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/ki.1981.33","article-title":"Glomerular hemodynamics in experimental diabetes mellitus","volume":"19","author":"Hostetter","year":"1981","journal-title":"Kidney Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1172\/JCI112013","article-title":"Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass","volume":"76","author":"Anderson","year":"1985","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1172\/JCI112521","article-title":"Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension","volume":"77","author":"Zatz","year":"1986","journal-title":"J. Clin. Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.nefro.2017.07.003","article-title":"The renin-angiotensin-aldosterone system blockade in patients with advanced diabetic kidney disease","volume":"38","author":"Bermejo","year":"2018","journal-title":"Nefrologia"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1471-4892(02)00141-8","article-title":"Treatment of type 2 diabetic nephropathy by blockade of the renin-angiotensin system: A comparison of angiotensin-converting-enzyme inhibitors and angiotensin receptor antagonists","volume":"2","author":"Hsueh","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3317\/jraas.2005.011","article-title":"Preventing end-stage renal disease in diabetic patients\u2014Dual blockade of the renin-angiotensin system (Part II)","volume":"6","author":"Jacobsen","year":"2005","journal-title":"J. Renin Angiotensin Aldosterone Syst. JRAAS"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/ajh.2008.206","article-title":"Effects of renin-angiotensin system blockers on renal outcomes and all-cause mortality in patients with diabetic nephropathy: An updated meta-analysis","volume":"21","author":"Sarafidis","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1152\/physiol.00024.2007","article-title":"Renin release","volume":"22","author":"Schweda","year":"2007","journal-title":"Physiology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"C1261","DOI":"10.1152\/ajpcell.00195.2008","article-title":"Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells","volume":"295","author":"Lim","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.yjmcc.2008.01.007","article-title":"Negative regulation of beta-adrenergic function by hydrogen sulphide in the rat hearts","volume":"44","author":"Yong","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1681\/ASN.2009090949","article-title":"Hydrogen sulfide inhibits plasma renin activity","volume":"21","author":"Lu","year":"2010","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/ars.2012.4888","article-title":"Hydrogen sulfide prevents heart failure development via inhibition of renin release from mast cells in isoproterenol-treated rats","volume":"20","author":"Liu","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jacbts.2018.08.011","article-title":"Hydrogen sulfide attenuates renin angiotensin and aldosterone pathological signaling to preserve kidney function and improve exercise tolerance in heart failure","volume":"3","author":"Li","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_82","first-page":"441","article-title":"Role of angiotensin II in diabetic nephropathy","volume":"17","author":"Kennefick","year":"1997","journal-title":"Semin. Nephrol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1159\/000066656","article-title":"The renin-angiotensin system and progression of renal disease: From hemodynamics to cell biology","volume":"93","author":"Wolf","year":"2003","journal-title":"Nephron. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.peptides.2011.05.012","article-title":"New insights and perspectives on intrarenal renin-angiotensin system: Focus on intracrine\/intracellular angiotensin II","volume":"32","author":"Zhuo","year":"2011","journal-title":"Peptides"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"v21","DOI":"10.1093\/ndt\/gfg1037","article-title":"Treatment of diabetic nephropathy with angiotensin II blockers","volume":"18","author":"Sonkodi","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Xue, H., Yuan, P., Ni, J., Li, C., Shao, D., Liu, J., Shen, Y., Wang, Z., Zhou, L., and Zhang, W. (2013). H2S inhibits hyperglycemia-induced intrarenal renin-angiotensin system activation via attenuation of reactive oxygen species generation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074366"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.2174\/092986710793348581","article-title":"Oxidative stress in diabetic nephropathy","volume":"17","author":"Kashihara","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"LeBaron, T.W., Kura, B., Kalocayova, B., Tribulova, N., and Slezak, J. (2019). A new approach for the prevention and treatment of cardiovascular disorders. Molecular hydrogen significantly reduces the effects of oxidative stress. Molecules, 24.","DOI":"10.3390\/molecules24112076"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"S241","DOI":"10.1097\/01.ASN.0000077410.66390.0F","article-title":"Reactive oxygen species-regulated signaling pathways in diabetic nephropathy","volume":"14","author":"Lee","year":"2003","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1681\/ASN.V134894","article-title":"Role of high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells","volume":"13","author":"Ha","year":"2002","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1046\/j.1523-1755.2000.07704.x","article-title":"Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose","volume":"77","author":"Ha","year":"2000","journal-title":"Kidney Int. Suppl."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1523-1755.2001.00469.x","article-title":"Hydrogen peroxide increases extracellular matrix mRNA through TGF-beta in human mesangial cells","volume":"59","author":"Alcami","year":"2001","journal-title":"Kidney Int."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1681\/ASN.2004050425","article-title":"Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells","volume":"16","author":"Rhyu","year":"2005","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/1389450115666140321120635","article-title":"Oxidative stress: Meeting multiple targets in pathogenesis of diabetic nephropathy","volume":"15","author":"Arora","year":"2014","journal-title":"Curr. Drug Targets"},{"key":"ref_95","first-page":"181","article-title":"Protective effect of hydrogen sulfide on kidneys of type 1 diabetic rats","volume":"32","author":"Yang","year":"2016","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi Zhongguo Yingyong Shenglixue Zazhi Chin. J. Appl. Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1073\/pnas.91.21.9926","article-title":"Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2\/AP1 repeat of the beta-globin locus control region","volume":"91","author":"Moi","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1089\/ars.2010.3222","article-title":"Discovery of the negative regulator of Nrf2, Keap1: A historical overview","volume":"13","author":"Itoh","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"10074","DOI":"10.3390\/molecules190710074","article-title":"Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway","volume":"19","author":"Keum","year":"2014","journal-title":"Molecules"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2013.02.008","article-title":"Regulation of Nrf2-an update","volume":"66","author":"Niture","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1128\/MCB.26.8.2887-2900.2006","article-title":"Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model","volume":"26","author":"Tong","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh","year":"1999","journal-title":"Genes Dev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1128\/MCB.24.24.10941-10953.2004","article-title":"Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex","volume":"24","author":"Zhang","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1365-2443.2001.00469.x","article-title":"Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription","volume":"6","author":"Katoh","year":"2001","journal-title":"Genes Cells Devoted Mol. Cell. Mech."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"31556","DOI":"10.1074\/jbc.M403061200","article-title":"Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron","volume":"279","author":"McMahon","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1158\/0008-5472.CAN-12-3386","article-title":"RXRalpha inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2","volume":"73","author":"Wang","year":"2013","journal-title":"Cancer Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tibs.2008.12.008","article-title":"NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer","volume":"34","author":"Hayes","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.abb.2004.10.012","article-title":"Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome","volume":"433","author":"Katoh","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1128\/MCB.00868-15","article-title":"Characterizations of three major cysteine sensors of Keap1 in stress response","volume":"36","author":"Saito","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1073\/pnas.0307301101","article-title":"Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers","volume":"101","author":"Wakabayashi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ki.2012.439","article-title":"Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease","volume":"83","author":"Ruiz","year":"2013","journal-title":"Kidney Int."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"306073","DOI":"10.1155\/2013\/306073","article-title":"Preventive and therapeutic effects of MG132 by activating Nrf2-ARE signaling pathway on oxidative stress-induced cardiovascular and renal injury","volume":"2013","author":"Cui","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_112","first-page":"107","article-title":"Combating oxidative stress in diabetic complications with Nrf2 activators: How much is too much?","volume":"19","author":"Tan","year":"2014","journal-title":"Redox Rep. Commun. Free Radic. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000475890","article-title":"Targeting the KEAP1-NRF2 system to prevent kidney disease progression","volume":"45","author":"Nezu","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3797802","DOI":"10.1155\/2017\/3797802","article-title":"Role of nuclear factor erythroid 2-related factor 2 in diabetic nephropathy","volume":"2017","author":"Cui","year":"2017","journal-title":"J. Diabetes Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/CS20140460","article-title":"Hydrogen sulfide attenuates the development of diabetic cardiomyopathy","volume":"128","author":"Zhou","year":"2015","journal-title":"Clin. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2337\/db16-0020","article-title":"Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation","volume":"65","author":"Xie","year":"2016","journal-title":"Diabetes"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2015.05.001","article-title":"The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: A novel mechanism mediated by the activation of Nrf2","volume":"761","author":"Yang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.redox.2018.01.012","article-title":"Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity","volume":"15","author":"Cao","year":"2018","journal-title":"Redox Biol."},{"key":"ref_119","first-page":"1","article-title":"Inflammation in diabetic kidney disease","volume":"10","author":"Valdivielso","year":"2018","journal-title":"Nephron"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00125-016-3873-z","article-title":"Multiple benefits of targeting inflammation in the treatment of type 2 diabetes","volume":"59","author":"Donath","year":"2016","journal-title":"Diabetologia"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s001250051058","article-title":"Is type II diabetes mellitus a disease of the innate immune system?","volume":"41","author":"Pickup","year":"1998","journal-title":"Diabetologia"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1053\/j.ackd.2017.12.002","article-title":"Inflammatory mechanisms as new biomarkers and therapeutic targets for diabetic kidney disease","volume":"25","author":"Alicic","year":"2018","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4239\/wjd.v5.i4.431","article-title":"Inflammation in diabetic kidney disease","volume":"5","year":"2014","journal-title":"World J. Diabetes"},{"key":"ref_124","first-page":"2601","article-title":"Role of inflammation in diabetic complications","volume":"20","author":"Navarro","year":"2005","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transplant. Assoc. Eur. Ren. Assoc."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11892-006-0080-1","article-title":"Inflammation and diabetic nephropathy","volume":"6","author":"Mora","year":"2006","journal-title":"Curr. Diabetes Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3389\/fphar.2017.00810","article-title":"An update on AMPK in hydrogen sulfide pharmacology","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"F410","DOI":"10.1152\/ajprenal.00145.2009","article-title":"Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure","volume":"297","author":"Sen","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pharmthera.2018.08.014","article-title":"Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly","volume":"193","author":"Toba","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2174\/157016110790886947","article-title":"Impact of the renin-angiotensin-aldosterone-system on cardiovascular and renal complications in diabetes mellitus","volume":"8","author":"Hayashi","year":"2010","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"E1365","DOI":"10.1152\/ajpendo.00604.2012","article-title":"Hydrogen sulfide deficiency and diabetic renal remodeling: Role of matrix metalloproteinase-9","volume":"304","author":"Kundu","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"125469","DOI":"10.1155\/2013\/125469","article-title":"MicroRNAs in kidney fibrosis and diabetic nephropathy: Roles on EMT and EndMT","volume":"2013","author":"Srivastava","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_132","first-page":"2901049","article-title":"Epigenetic modification mechanisms involved in inflammation and fibrosis in renal pathology","volume":"2018","author":"Marchant","year":"2018","journal-title":"Mediators Inflamm"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.2337\/db13-1029","article-title":"Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen","volume":"63","author":"Kanasaki","year":"2014","journal-title":"Diabetes"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.med.57.121304.131342","article-title":"Toward a unified theory of renal progression","volume":"57","author":"Harris","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1681\/ASN.2008050513","article-title":"Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition","volume":"19","author":"Zeisberg","year":"2008","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1440-1681.2011.05497.x","article-title":"Epigenetics: Deciphering its role in diabetes and its chronic complications","volume":"38","author":"Villeneuve","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fphar.2014.00070","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline: A valuable endogenous anti-fibrotic peptide for combating kidney fibrosis in diabetes","volume":"5","author":"Kanasaki","year":"2014","journal-title":"Front. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2353\/ajpath.2009.090096","article-title":"Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice","volume":"175","author":"Li","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1152\/physiolgenomics.00082.2016","article-title":"Serum response factor induces endothelial-mesenchymal transition in glomerular endothelial cells to aggravate proteinuria in diabetic nephropathy","volume":"48","author":"Zhao","year":"2016","journal-title":"Physiol. Genom."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1440-1797.2010.01319.x","article-title":"Review: Endothelial-myofibroblast transition, a new player in diabetic renal fibrosis","volume":"15","author":"Li","year":"2010","journal-title":"Nephrology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.semcancer.2012.04.004","article-title":"Endothelial-mesenchymal transition and its contribution to the emergence of stem cell phenotype","volume":"22","author":"Medici","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.lfs.2015.11.025","article-title":"Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway","volume":"144","author":"Ying","year":"2016","journal-title":"Life Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"F1060","DOI":"10.1152\/ajprenal.00191.2002","article-title":"Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models","volume":"285","author":"Zeisberg","year":"2003","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/1878-0261.12017","article-title":"Epithelial-mesenchymal transition in tumor metastasis","volume":"11","author":"Yeung","year":"2017","journal-title":"Mol. Oncol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00441-011-1227-1","article-title":"The role of EMT in renal fibrosis","volume":"347","author":"Carew","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3390\/cells4040631","article-title":"Epithelial-to-mesenchymal transition in diabetic nephropathy: Fact or fiction?","volume":"4","author":"Loeffler","year":"2015","journal-title":"Cells"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2613.2011.00775.x","article-title":"Epithelial-mesenchymal transition in renal fibrosis\u2014Evidence for and against","volume":"92","author":"Fragiadaki","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","article-title":"BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury","volume":"9","author":"Zeisberg","year":"2003","journal-title":"Nat. Med."},{"key":"ref_151","first-page":"131","article-title":"The role of TGF-beta and epithelial-to mesenchymal transition in diabetic nephropathy","volume":"22","author":"Hills","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.juro.2016.05.029","article-title":"GYY4137, a slow-releasing hydrogen sulfide donor, ameliorates renal damage associated with chronic obstructive uropathy","volume":"196","author":"Lin","year":"2016","journal-title":"J. Urol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.niox.2018.03.002","article-title":"Daily therapy with a slow-releasing H2S donor GYY4137 enables early functional recovery and ameliorates renal injury associated with urinary obstruction","volume":"76","author":"Lin","year":"2018","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.niox.2017.12.004","article-title":"Is hydrogen sulfide a potential novel therapy to prevent renal damage during ureteral obstruction?","volume":"73","author":"Lin","year":"2018","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.bbrc.2018.05.032","article-title":"Induction of inactive TGF-beta1 monomer formation by hydrogen sulfide contributes to its suppressive effects on Ang II- and TGF-beta1-induced EMT in renal tubular epithelial cells","volume":"501","author":"Huang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Guo, L., Peng, W., Tao, J., Lan, Z., Hei, H., Tian, L., Pan, W., Wang, L., and Zhang, X. (2016). Hydrogen sulfide inhibits transforming growth Factor-Beta1-induced EMT via Wnt\/Catenin pathway. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0147018"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1074\/jbc.M111.278325","article-title":"Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells","volume":"287","author":"Lee","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_158","first-page":"S50","article-title":"Does nitric oxide, an inflammatory mediator of glomerular mesangial cells, have a role in diabetic nephropathy?","volume":"51","author":"Pfeilschifter","year":"1995","journal-title":"Kidney Int. Suppl."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0168-8227(99)00044-3","article-title":"Pathogenesis of diabetic nephropathy: The role of oxidative stress and protein kinase C","volume":"45","author":"Ha","year":"1999","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1046\/j.1523-1755.2000.07711.x","article-title":"Apoptosis and extracellular matrix-cell interactions in kidney disease","volume":"77","author":"Makino","year":"2000","journal-title":"Kidney Int. Suppl."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1046\/j.1523-1755.1998.00116.x","article-title":"Regulation of survival and death of mesangial cells by extracellular matrix","volume":"54","author":"Sugiyama","year":"1998","journal-title":"Kidney Int."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1523-1755.2001.00766.x","article-title":"Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease","volume":"60","author":"Guan","year":"2001","journal-title":"Kidney Int."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/pr.59.3.3","article-title":"The intrarenal renin-angiotensin system: From physiology to the pathobiology of hypertension and kidney disease","volume":"59","author":"Kobori","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.lfs.2019.02.027","article-title":"Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy","volume":"221","author":"Malek","year":"2019","journal-title":"Life Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.biopha.2018.08.066","article-title":"Mast cell population in the development of diabetic nephropathy: Effects of renin angiotensin system inhibition","volume":"107","author":"Filho","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.amjmed.2003.09.034","article-title":"The renin-angiotensin-aldosterone system and the kidney: Effects on kidney disease","volume":"116","author":"Brewster","year":"2004","journal-title":"Am. J. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/hr.2010.143","article-title":"Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species\u2014ERK\/JNK pathways","volume":"33","author":"Ohashi","year":"2010","journal-title":"Hypertens. Res. Off. J. Jpn. Soc. Hypertens."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1046\/j.1523-1755.2002.00168.x","article-title":"Glucose-induced oxidative stress in mesangial cells","volume":"61","author":"Catherwood","year":"2002","journal-title":"Kidney Int."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00592-013-0501-y","article-title":"Hydrogen sulfide induces heme oxygenase-1 in human kidney cells","volume":"51","author":"Shaw","year":"2014","journal-title":"Acta Diabetol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1159\/000461483","article-title":"High glucose induces mouse mesangial cell overproliferation via inhibition of hydrogen sulfide synthesis in a TLR-4-dependent manner","volume":"41","author":"Ding","year":"2017","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/MNH.0b013e3282f2904d","article-title":"The podocyte and diabetes mellitus: Is the podocyte the key to the origins of diabetic nephropathy?","volume":"17","author":"Reddy","year":"2008","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.2337\/diabetes.54.6.1626","article-title":"From the periphery of the glomerular capillary wall toward the center of disease: Podocyte injury comes of age in diabetic nephropathy","volume":"54","author":"Wolf","year":"2005","journal-title":"Diabetes"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ki.2008.128","article-title":"Proteinuria in diabetic kidney disease: A mechanistic viewpoint","volume":"74","author":"Jefferson","year":"2008","journal-title":"Kidney Int."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Hishikawa, A., Hayashi, K., and Itoh, H. (2018). Transcription factors as therapeutic targets in chronic kidney disease. Molecules, 23.","DOI":"10.3390\/molecules23051123"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s11255-016-1488-4","article-title":"Inflammation, oxidative stress, apoptosis, and autophagy in diabetes mellitus and diabetic kidney disease: The four horsemen of the apocalypse","volume":"49","author":"Turkmen","year":"2017","journal-title":"Int. Urol. Nephrol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2337\/diabetes.55.01.06.db05-0894","article-title":"Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy","volume":"55","author":"Susztak","year":"2006","journal-title":"Diabetes"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1100\/tsw.2009.133","article-title":"The podocyte in diabetic kidney disease","volume":"9","author":"MacLeod","year":"2009","journal-title":"Sci. World J."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1159\/000148209","article-title":"Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes","volume":"28","author":"Chen","year":"2008","journal-title":"Am. J. Nephrol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1172\/JCI44771","article-title":"mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice","volume":"121","author":"Inoki","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1172\/JCI39492","article-title":"Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice","volume":"120","author":"Hartleben","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1172\/JCI44774","article-title":"Role of mTOR in podocyte function and diabetic nephropathy in humans and mice","volume":"121","author":"Godel","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_182","first-page":"6814","article-title":"Effects of hydrogen sulfide on high glucose-induced glomerular podocyte injury in mice","volume":"8","author":"Liu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bbrc.2016.03.154","article-title":"Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy","volume":"473","author":"Qian","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"12014","DOI":"10.1074\/jbc.M114.615377","article-title":"Tadalafil integrates nitric oxide-hydrogen sulfide signaling to inhibit high glucose-induced matrix protein synthesis in podocytes","volume":"290","author":"Lee","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_185","first-page":"565","article-title":"Metformin and diabetic kidney disease: A mini-review on recent findings","volume":"24","author":"Nasri","year":"2014","journal-title":"Iran. J. Pediatr."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1734-1140(13)71053-3","article-title":"Metformin raises hydrogen sulfide tissue concentrations in various mouse organs","volume":"65","author":"Wilinski","year":"2013","journal-title":"Pharmacol. Rep. PR"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"10924","DOI":"10.1038\/s41598-017-11256-3","article-title":"GYY4137, a hydrogen sulfide donor modulates miR194-dependent collagen realignment in diabetic kidney","volume":"7","author":"John","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2174\/1871530318666180426100532","article-title":"Hydrogen sulfide in diabetic complications: Focus on molecular mechanisms","volume":"18","author":"Qian","year":"2018","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.pathol.4.110807.092150","article-title":"A glimpse of various pathogenetic mechanisms of diabetic nephropathy","volume":"6","author":"Kanwar","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/kisup.2014.21","article-title":"Obesity, oxidative stress, and fibrosis in chronic kidney disease","volume":"4","author":"Sharma","year":"2014","journal-title":"Kidney Int. Suppl."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2174\/1570161115666170202162345","article-title":"Matrix gelatinases in atherosclerosis and diabetic nephropathy: Progress and challenges","volume":"15","author":"Dimas","year":"2017","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1681\/ASN.2005050549","article-title":"Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats","volume":"17","author":"Lloberas","year":"2006","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"F617","DOI":"10.1152\/ajprenal.00278.2006","article-title":"A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy","volume":"292","author":"Lee","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"37503","DOI":"10.1074\/jbc.M110.136796","article-title":"AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes","volume":"285","author":"Eid","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"636.e1","DOI":"10.1016\/j.ajog.2016.07.036","article-title":"Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal N (G)-Nitro-L-arginine-methyl ester (L-NAME)-induced fetal programming of hypertension in adult male offspring","volume":"215","author":"Tain","year":"2016","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/15\/2857\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:09:07Z","timestamp":1760188147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/15\/2857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,6]]},"references-count":195,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2019,8]]}},"alternative-id":["molecules24152857"],"URL":"https:\/\/doi.org\/10.3390\/molecules24152857","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,6]]}}}