{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:52:11Z","timestamp":1789098731193,"version":"build-2803163510"},"reference-count":16,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T00:00:00Z","timestamp":1565395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M622985"],"award-info":[{"award-number":["2017M622985"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Provincial Youth Science and Technology Innovation Team","award":["2016TD0006, 2015TD0028"],"award-info":[{"award-number":["2016TD0006, 2015TD0028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Two new terpene glycosides (1\u20132) along with two known analogs (3\u20134) were obtained from the root of Sanguisorba officinalis, which is a common traditional Chinese medicine (TCM). Their structures were elucidated by nuclear magnetic resonance (NMR), electrospray ionization high resolution mass spectrometry (HRESIMS), and a hydrolysis reaction, as well as comparison of these data with the literature data. Compounds 1\u20134 exhibited anti-inflammatory properties in vitro by attenuating the production of inflammatory mediators, such as nitric oxide (NO) as well as tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-6 (IL-6). An anti-inflammatory assay based on the zebrafish experimental platform indicated that compound 1 had good anti-inflammatory activity in vivo by not only regulating the distribution, but also by reducing the amount of the macrophages of the zebrafish exposed to copper sulfate.<\/jats:p>","DOI":"10.3390\/molecules24162906","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T06:38:02Z","timestamp":1565591882000},"page":"2906","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Terpene Glycosides from Sanguisorba officinalis and Their Anti-Inflammatory Effects"],"prefix":"10.3390","volume":"24","author":[{"given":"Da-Le","family":"Guo","sequence":"first","affiliation":[{"name":"The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tan","sequence":"additional","affiliation":[{"name":"The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ying","family":"Jin","sequence":"additional","affiliation":[{"name":"The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ju","sequence":"additional","affiliation":[{"name":"The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Xing","family":"Cao","sequence":"additional","affiliation":[{"name":"The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Deng","sequence":"additional","affiliation":[{"name":"The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Na","family":"Wang","sequence":"additional","affiliation":[{"name":"The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"School of Nursing, Sichuan Tianyi College, Mianzhu 618200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6400-6167","authenticated-orcid":false,"given":"Yu-Cheng","family":"Gu","sequence":"additional","affiliation":[{"name":"Syngenta Jealott\u2019s Hill International Research Centre, Berkshire RG42 6EY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Deng","sequence":"additional","affiliation":[{"name":"The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s11094-016-1431-0","article-title":"Chemical composition, antioxidant and antimicrobial activities of Sanguisorba officinalis L. extracts","volume":"50","author":"Bylka","year":"2016","journal-title":"Pharm. Chem. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.bmcl.2018.04.033","article-title":"Anti-allergic inflflammatory components from Sanguisorba offificinalis L.","volume":"28","author":"Su","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s12272-018-1035-1","article-title":"Chemical constituents from Sanguisorba officinalis L. and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells","volume":"41","author":"Su","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1744-7909.2005.00038.x","article-title":"Two new triterpenoids from the roots of Sanguisorba officinalis L.","volume":"47","author":"Zhang","year":"2005","journal-title":"J. Integr. Plant. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1271\/bbb.70268","article-title":"Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient","volume":"72","author":"Kim","year":"2008","journal-title":"Biosci. Biotech. Bioch."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wang, L.N., Qin, L.L., He, J.L., Li, X.H., Cao, Z.X., Gu, Y.C., Deng, F., and Deng, Y. (2018). Aryl-tetralin type lignan isolated from Sanguisorba officinalis. J. Asian Nat. Prod. Res.","DOI":"10.1080\/10286020.2018.1487957"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/10286020.2011.634803","article-title":"Two new rhamnopyranosides of neolignans from Sanguisorba officinalis","volume":"14","author":"Hu","year":"2012","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ijbiomac.2012.05.029","article-title":"Anti-tumor and immunomodulating activities of a polysaccharide from the root of Sanguisorba officinalis L.","volume":"51","author":"Cai","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13020-019-0244-y","article-title":"A tannin compound from Sanguisorba ofcinalis blocks Wnt\/\u03b2-catenin signaling pathway and induces apoptosis of colorectal cancer cells","volume":"14","author":"Li","year":"2019","journal-title":"Chin. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.3390\/molecules17077629","article-title":"Terpene glycosides from the root of Sanguisorba officinalis L. and their hemostatic activities","volume":"17","author":"Sun","year":"2012","journal-title":"Molecules"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.tcb.2005.09.002","article-title":"Inflammatory cells during wound repair: the good, the bad and the ugly","volume":"15","author":"Martin","year":"2005","journal-title":"Trends Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"d\u2019Alencon, C.A., Pe\u00f1a, O.A., Wittmann, C., Gallardo, V.E., Jones, R.A., Loosli, F., Liebel, U., Grabher, C., and Allende, M.L. (2010). A high-throughput chemically induced inflammation assay in zebrafish. BMC Biol., 8.","DOI":"10.1186\/1741-7007-8-151"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrd4627","article-title":"Zebrafish as tools for drug discovery","volume":"14","author":"MacRae","year":"2015","journal-title":"Nat. Rev. Drug. Discov."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2147\/DDDT.S133069","article-title":"Rhein attenuates inflammation through inhibition of NF-\u03baB and NALP3 inflammasome in vivo and in vitro","volume":"11","author":"Ge","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1248\/yakushi1947.103.5_508","article-title":"Studies on the constituents of Cistanchis herba. I","volume":"103","author":"Kobayashi","year":"1983","journal-title":"Yakugaku Zasshi."},{"key":"ref_16","first-page":"1763","article-title":"Ingenane diterpene ester constituents from Tibetan medicine Euphorbia wallichii","volume":"36","author":"Li","year":"2005","journal-title":"Chin. Tradit. Herb. Drugs"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/16\/2906\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:10:09Z","timestamp":1760188209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/16\/2906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,10]]},"references-count":16,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2019,8]]}},"alternative-id":["molecules24162906"],"URL":"https:\/\/doi.org\/10.3390\/molecules24162906","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,10]]}}}