{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:26:16Z","timestamp":1790486776240,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2015-04815"],"award-info":[{"award-number":["RGPIN-2015-04815"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010622","name":"Fondation des Maladies de l'Oeil","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/100010622","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CHU de Quebec Foundation","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"name":"Quebec Glaucoma Foundation","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"DOI":"10.13039\/100008071","name":"Glaucoma Research Society of Canada","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/100008071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["33036"],"award-info":[{"award-number":["33036"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Antoine Turmel Foundation","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nanotechnologies are increasingly being developed for medical purposes. However, these nanomaterials require ultrastability for better control of their pharmacokinetics. The present study describes three types of ultrastable gold nanoparticles stabilized by thiolated polyethylene glycol groups remaining intact when subjected to some of the harshest conditions described thus far in the literature, such as autoclave sterilization, heat and freeze-drying cycles, salts exposure, and ultracentrifugation. Their stability is characterized by transmission electron microscopy, UV-visible spectroscopy, and dynamic light scattering. For comparison purposes, two conventional nanoparticle types were used to assess their colloidal stability under all conditions. The ability of ultrastable gold nanoparticles to encapsulate bimatoprost, a drug for glaucoma treatment, is demonstrated. MTS assays on human corneal epithelial cells is assessed without changing cell viability. The impact of ultrastable gold nanoparticles on wound healing dynamics is assessed on tissue engineered corneas. These results highlight the potential of ultrastable gold nanoparticles as a drug delivery system in ocular therapy.<\/jats:p>","DOI":"10.3390\/molecules24162929","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T03:59:26Z","timestamp":1565755166000},"page":"2929","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System"],"prefix":"10.3390","volume":"24","author":[{"given":"Florence","family":"Masse","sequence":"first","affiliation":[{"name":"Research Center of CHU de Qu\u00e9bec, CUO-Recherche and Universit\u00e9 Laval, Faculty of Medicine, Ophthalmology Department, chemin Ste-Foy 1050, G1S 4L8, Qu\u00e9bec (Qu\u00e9bec), Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Desjardins","sequence":"additional","affiliation":[{"name":"Research Center of CHU de Qu\u00e9bec, CUO-Recherche and Universit\u00e9 Laval, Faculty of Medicine, Ophthalmology Department, chemin Ste-Foy 1050, G1S 4L8, Qu\u00e9bec (Qu\u00e9bec), Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-1323","authenticated-orcid":false,"given":"Mathieu","family":"Ouellette","sequence":"additional","affiliation":[{"name":"Research Center of CHU de Qu\u00e9bec, CUO-Recherche and Universit\u00e9 Laval, Faculty of Medicine, Ophthalmology Department, chemin Ste-Foy 1050, G1S 4L8, Qu\u00e9bec (Qu\u00e9bec), Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Couture","sequence":"additional","affiliation":[{"name":"Research Center of CHU de Qu\u00e9bec, CUO-Recherche and Universit\u00e9 Laval, Faculty of Medicine, Ophthalmology Department, chemin Ste-Foy 1050, G1S 4L8, Qu\u00e9bec (Qu\u00e9bec), Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Mohamed","family":"Omar","sequence":"additional","affiliation":[{"name":"Research Center of CHU de Qu\u00e9bec, CUO-Recherche and Universit\u00e9 Laval, Faculty of Medicine, Ophthalmology Department, chemin Ste-Foy 1050, G1S 4L8, Qu\u00e9bec (Qu\u00e9bec), Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Pernet","sequence":"additional","affiliation":[{"name":"Research Center of CHU de Qu\u00e9bec, CUO-Recherche and Universit\u00e9 Laval, Faculty of Medicine, Ophthalmology Department, chemin Ste-Foy 1050, G1S 4L8, Qu\u00e9bec (Qu\u00e9bec), Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"Research Center of CHU de Qu\u00e9bec, CUO-Recherche and Universit\u00e9 Laval, Faculty of Medicine, Ophthalmology Department, chemin Ste-Foy 1050, G1S 4L8, Qu\u00e9bec (Qu\u00e9bec), Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8281-5235","authenticated-orcid":false,"given":"Elodie","family":"Boisselier","sequence":"additional","affiliation":[{"name":"Research Center of CHU de Qu\u00e9bec, CUO-Recherche and Universit\u00e9 Laval, Faculty of Medicine, Ophthalmology Department, chemin Ste-Foy 1050, G1S 4L8, Qu\u00e9bec (Qu\u00e9bec), Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1517\/17425241003777010","article-title":"Gold nanoparticles: Opportunities and challenges in nanomedicine","volume":"7","author":"Arvizo","year":"2010","journal-title":"Expert Opin. 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