{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:45:34Z","timestamp":1789429534366,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bioenutra S.r.l.","award":["BIOENUTRA 2018"],"award-info":[{"award-number":["BIOENUTRA 2018"]}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["FFABR 2017 to S. Leone"],"award-info":[{"award-number":["FFABR 2017 to S. Leone"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>MOMAST(\u00ae) HY100 and MOMAST(\u00ae) HP30 are polyphenolic liquid complexes from olive pressing juice with a total polyphenolic content of 100 g\/kg (at least 50% as hydroxytyrosol) and 36 g\/kg (at least 30% as hydroxytyrosol), respectively. We investigated the potential protective role of MOMAST(\u00ae) HY100 and MOMAST(\u00ae) HP30 on isolated rat colon, liver, heart, and prefrontal cortex specimens treated with Escherichia coli lipopolysaccharide (LPS), a validated ex vivo model of inflammation, by measuring the production of prostaglandin (PG)E2, 8-iso-PGF2\u03b1, lactate dehydrogenase (LDH), as well as cyclooxygenase (COX)-2, tumor necrosis factor \u03b1 (TNF\u03b1), and inducible nitric oxide synthase (iNOS) mRNA levels. MOMAST(\u00ae) HY100 decreased LPS-stimulated PGE2 and LDH levels in all tested tissues. Following treatment with MOMAST(\u00ae) HY100, we found a significant reduction in iNOS levels in prefrontal cortex and heart specimens, COX-2 and TNF\u03b1 mRNA levels in heart specimens, and 8-iso-PGF2\u03b1 levels in liver specimens. On the other hand, MOMAST(\u00ae) HP30 was found to blunt COX-2, TNF\u03b1, and iNOS mRNA levels, as well as 8-iso-PGF2\u03b1 in cortex, liver, and colon specimens. MOMAST(\u00ae) HP30 was also found to decrease PGE2 levels in liver specimens, while it decreased iNOS mRNA, LDH, and 8-iso-PGF2\u03b1 levels in heart specimens. Both MOMAST(\u00ae) HY100 and MOMAST(\u00ae) HP30 exhibited protective effects on multiple inflammatory and oxidative stress pathways.<\/jats:p>","DOI":"10.3390\/molecules24163002","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T11:22:38Z","timestamp":1566213758000},"page":"3002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Protective Effects Induced by Two Polyphenolic Liquid Complexes from Olive (Olea europaea, mainly Cultivar Coratina) Pressing Juice in Rat Isolated Tissues Challenged with LPS"],"prefix":"10.3390","volume":"24","author":[{"given":"Lucia","family":"Recinella","sequence":"first","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University, 66013 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Chiavaroli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University, 66013 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giustino","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University, 66013 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7346-7395","authenticated-orcid":false,"given":"Luigi","family":"Menghini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University, 66013 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-9407","authenticated-orcid":false,"given":"Claudio","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University, 66013 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-4432","authenticated-orcid":false,"given":"Lorenzo","family":"Di Cesare Mannelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ghelardini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University, 66013 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Leone","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University, 66013 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tifs.2013.03.003","article-title":"Protective role of oleuropein and its metabolite hydroxytyrosol on cancer","volume":"31","author":"Mayas","year":"2013","journal-title":"Trends Food Sci. Technol."},{"key":"ref_2","first-page":"799","article-title":"Therapeutics role of olive fruits\/oil in the prevention of diseases via modulation of anti-oxidant, anti-tumour and genetic activity","volume":"7","author":"Rahmani","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jnutbio.2005.05.013","article-title":"Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes","volume":"16","author":"Masella","year":"2005","journal-title":"J. Nutr. Biochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2174\/138955708783955926","article-title":"Biological and pharmacological activities of iridoids: recent developments","volume":"8","author":"Tundis","year":"2008","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gorzynik-Debicka, M., Przychodzen, P., Cappello, F., Kuban-Jankowska, A., Marino Gammazza, A., Knap, N., Wozniak, M., and Gorska-Ponikowska, M. (2018). Potential Health Benefits of Olive Oil and Plant Polyphenols. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030686"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1079\/NRR200495","article-title":"The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health","volume":"18","author":"Tripoli","year":"2005","journal-title":"Nutr. Res. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/jn\/136.3.614","article-title":"Virgin olive oil phenols inhibit proliferation of human promyelocytic leukemia cells (HL60) by inducing apoptosis and differentiation","volume":"136","author":"Fabiani","year":"2006","journal-title":"J. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0021-9673(95)01375-X","article-title":"Characterization of phenolic and secoiridoid aglycons present in virgin olive oil by gas chromatography-chemical ionization mass spectrometry","volume":"736","author":"Angerosa","year":"1996","journal-title":"J. Chromatogr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s11746-997-0054-8","article-title":"Evolution of phenolic compounds in virgin olive oil during storage","volume":"74","author":"Cinquanta","year":"1997","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1753-4887.2009.00248.x","article-title":"Olive tree (Olea europaea) leaves: Potential beneficial effects on human health","volume":"67","author":"El","year":"2009","journal-title":"Nutr. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez, L., Ros, G., and Nieto, G. (2018). Hydroxytyrosol: Health Benefits and Use as Functional Ingredient in Meat. Medicines (Basel), 23.","DOI":"10.3390\/medicines5010013"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.fct.2019.01.035","article-title":"Multiple pharmacognostic characterization on hemp commercial cultivars: Focus on inflorescence water extract activity","volume":"125","author":"Ferrante","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Locatelli, M., Macchione, N., Ferrante, C., Chiavaroli, A., Recinella, L., Carradori, S., Zengin, G., Cesa, S., Leporini, L., and Leone, S. (2018). Graminex Pollen: Phenolic Pattern, Colorimetric Analysis and Protective Effects in Immortalized Prostate Cells (PC3) and Rat Prostate Challenged with LPS. Molecules, 23.","DOI":"10.3390\/molecules23051145"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.biopha.2018.07.169","article-title":"Polyphenolic composition, enzyme inhibitory effects ex-vivo and in-vivo studies on two Brassicaceae of north-central Italy","volume":"107","author":"Mollica","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.7326\/0003-4819-145-5-200609050-00006","article-title":"The effect of polyphenols in olive oil on heart disease risk factors: A randomized trial","volume":"145","author":"Covas","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Camargo, A., Ruano, J., Fernandez, J.M., Parnell, L.D., Jimenez, A., Santos-Gonzalez, M., Marin, C., Perez-Martinez, P., Uceda, M., and Lopez-Miranda, J. (2010). Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genomics, 11.","DOI":"10.1186\/1471-2164-11-253"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e57622","DOI":"10.1371\/journal.pone.0057622","article-title":"Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial","volume":"8","author":"Derraik","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.numecd.2014.09.001","article-title":"Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial","volume":"25","author":"Pons","year":"2015","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.scienta.2006.07.016","article-title":"Changes in oleuropein levels during differentiation and development of floral buds in \u2018Arbequina\u2019olives","volume":"110","author":"Malik","year":"2006","journal-title":"Sci. Horticult."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.1021\/jf020565+","article-title":"Protective effect of the phenolic fraction from virgin olive oils against oxidative stress in human cells","volume":"50","author":"Manna","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0024-3205(97)01150-8","article-title":"Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages","volume":"62","author":"Visioli","year":"1998","journal-title":"Life Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/01.ATV.0000062884.69432.A0","article-title":"Olive oil and red wine antioxidant polyphenols inhibit endothelial activation","volume":"23","author":"Carluccio","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1093\/jn\/130.12.2996","article-title":"Oleuropein, an antioxidant polyphenol from olive oil, is poorly absorbed from isolated perfused rat intestine","volume":"130","author":"Edgecombe","year":"2000","journal-title":"J. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8918","DOI":"10.1021\/jf0515680","article-title":"Evaluation of the antioxidant capacity of individual phenolic compounds in virgin olive oil","volume":"53","author":"Cerretani","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.bjp.0705776","article-title":"Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean?","volume":"142","author":"Halliwell","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1749-6632.1999.tb07814.x","article-title":"Fundamental aspects of reactive oxygen species, or what\u2019s the matter with oxygen?","volume":"893","author":"Fridovich","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0899-9007(02)00916-4","article-title":"Free radicals, antioxidants, and nutrition","volume":"18","author":"Fang","year":"2002","journal-title":"Nutrition"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e330","DOI":"10.1016\/j.orcp.2013.05.004","article-title":"Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer","volume":"7","author":"Matsuda","year":"2013","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1096\/fasebj.12.15.1777","article-title":"Increased F2-isoprostanes in Alzheimer\u2019s disease: evidence for enhanced lipid peroxidation in vivo","volume":"12","author":"Lee","year":"1998","journal-title":"FASEB J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.foodchem.2014.10.036","article-title":"Synthesis and antioxidant evaluation of isochroman-derivatives of hydroxytyrosol: Structure-activity relationship","volume":"173","author":"Mateos","year":"2015","journal-title":"Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1021\/jf901280r","article-title":"Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats","volume":"57","author":"Jemai","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/1043-6618(95)80032-8","article-title":"Formation of F2-isoprostanes in oxidized low density lipoprotein: inhibitory effect of hydroxytyrosol","volume":"31","author":"Salami","year":"1995","journal-title":"Pharmacol. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0049-3848(95)00043-7","article-title":"Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil","volume":"78","author":"Petroni","year":"1995","journal-title":"Thromb. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1271\/bbb.61.347","article-title":"Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives","volume":"61","author":"Kohyama","year":"1997","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1099-1573(1998)12:1+<S98::AID-PTR263>3.0.CO;2-M","article-title":"Oleuropein evaluated in vitro and in vivo as an antioxidant","volume":"12","author":"Speroni","year":"1998","journal-title":"Phytother. Res."},{"key":"ref_37","first-page":"25","article-title":"Single oral dose toxicity study of a-cypermethrin in rats","volume":"36","author":"Manna","year":"2004","journal-title":"Indian J. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.biopha.2017.02.042","article-title":"Ameliorative effect of chromium-d-phenylalanine complex on indomethacin-induced inflammatory bowel disease in rats","volume":"89","author":"Nagarjun","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.intimp.2013.03.008","article-title":"Protective effect of Bauhinia tomentosa on acetic acid induced ulcerative colitis by regulating antioxidant and inflammatory mediators","volume":"16","author":"Kannan","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.jnutbio.2013.08.007","article-title":"Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation","volume":"24","author":"Cabrerizo","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1084\/jem.175.6.1697","article-title":"Transfection of CD14 into 70Z\/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein","volume":"175","author":"Lee","year":"1992","journal-title":"J. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.intimp.2007.11.003","article-title":"Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways","volume":"8","author":"Yun","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0165-6147(02)00043-3","article-title":"Cyclooxygenase 2: A molecular target for cancer prevention and treatment","volume":"24","author":"Subbaramaiah","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_44","first-page":"291","article-title":"Roles of nitric oxide and superoxide in inflammation","volume":"225","author":"Salvemini","year":"2003","journal-title":"Methods Mol. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1074\/jbc.271.1.337","article-title":"Regulation of inducible nitric oxide synthase expression by macrophage purinoreceptors and calcium","volume":"271","author":"Denlinger","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/bj3160209","article-title":"Regulation of the mouse inducible-type nitric oxide synthase gene promoter by interferon-gamma, bacterial lipopolysaccharide and NG-monomethyl-L-arginine","volume":"316","author":"Weisz","year":"1996","journal-title":"Biochem. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1292\/jvms.18-0250","article-title":"Anti-inflammatory effects of olive-derived hydroxytyrosol on lipopolysaccharide-induced inflammation in RAW264.7 cells","volume":"80","author":"Yonezawa","year":"2018","journal-title":"J. Vet. Med. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jnutbio.2015.08.026","article-title":"Olive oil compounds inhibit the paracrine regulation of TNF-\u03b1-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression","volume":"27","author":"Lamy","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"52","DOI":"10.14715\/cmb\/2019.65.1.9","article-title":"Assessment of the anti-inflammatory, analgesic and sedative effects of oleuropein from Olea europaea L.","volume":"65","author":"Mao","year":"2019","journal-title":"Cell. Mol. Biol. (Noisy-le-grand)."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.bbrc.2014.03.094","article-title":"Influence of olive-derived hydroxytyrosol on the toll-like receptor 4-dependent inflammatory response of mouse peritoneal macrophages","volume":"446","author":"Takeda","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00210-005-1078-y","article-title":"Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation","volume":"371","author":"Maiuri","year":"2005","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1248\/bpb.32.578","article-title":"Suppressive effects of hydroxytyrosol on oxidative stress and nuclear Factor-kappaB activation in THP-1 cells","volume":"32","author":"Zhang","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/ptr.5850","article-title":"Protective Effects Induced by Microwave-Assisted Aqueous Harpagophytum Extract on Rat Cortex Synaptosomes Challenged with Amyloid \u03b2-Peptide","volume":"31","author":"Ferrante","year":"2017","journal-title":"Phytother Res."},{"key":"ref_54","first-page":"531","article-title":"Crocus sativus, Serenoa repens and Pinus massoniana extracts modulate inflammatory response in isolated rat prostate challenged with LPS","volume":"31","author":"Chiavaroli","year":"2017","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.foodres.2018.04.028","article-title":"stigmas and byproducts: Qualitative fingerprint, antioxidant potentials and enzyme inhibitory activities","volume":"109","author":"Menghini","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_56","first-page":"883","article-title":"Central apelin-13 administration modulates hypothalamic control of feeding","volume":"30","author":"Ferrante","year":"2016","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ghir.2014.12.007","article-title":"Increased locomotor and thermogenic activity in mice with targeted ablation of the GHRH gene","volume":"25","author":"Leone","year":"2015","journal-title":"Growth Horm. IGF Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4103\/0976-500X.119726","article-title":"How to calculate sample size in animal studies?","volume":"4","author":"Charan","year":"2013","journal-title":"J. Pharmacol. Pharmacother."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ghir.2017.10.007","article-title":"Effects of growth hormone-releasing hormone gene targeted ablation on ghrelin-induced feeding","volume":"37","author":"Recinella","year":"2017","journal-title":"Growth Horm. IGF Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/16\/3002\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:12:10Z","timestamp":1760188330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/16\/3002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,19]]},"references-count":60,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2019,8]]}},"alternative-id":["molecules24163002"],"URL":"https:\/\/doi.org\/10.3390\/molecules24163002","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,19]]}}}