{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:26:33Z","timestamp":1782829593596,"version":"3.54.5"},"reference-count":24,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Research Foundation of Korea (NRF)","award":["No. 2019R1F1A1044073"],"award-info":[{"award-number":["No. 2019R1F1A1044073"]}]},{"name":"the National Research Foundation of Korea (NRF)","award":["No.2019R1F1A1056887"],"award-info":[{"award-number":["No.2019R1F1A1056887"]}]},{"name":"the National Research Foundation of Korea (NRF)","award":["No.2019R1F1A1059492"],"award-info":[{"award-number":["No.2019R1F1A1059492"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Epidermal inflammation is caused by various bacterial infectious diseases that impair the skin health. Feruloylserotonin (FS) belongs to the hydroxycinnamic acid amides of serotonin, which mainly exists in safflower seeds and has been proven to have anti-inflammatory and antioxidant activities. Human epidermis mainly comprises keratinocytes whose inflammation causes skin problems. This study investigated the protective effects of FS on the keratinocyte with lipopolysaccharides (LPS)-induced human HaCaT cells and elucidated its underlying mechanisms of action. The mechanism was investigated by analyzing cell viability, PGE2 levels, cell apoptosis, nuclear factor erythroid 2-related factor 2 (Nrf2) translocation, and TLR4\/NF-\u03baB pathway. The anti-inflammatory effects of FS were assessed by inhibiting the inflammation via down-regulating the TLR4\/NF-\u03baB pathway. Additionally, FS promoted Nrf2 translocation to the nucleus, indicating that FS showed anti-oxidative activities. Furthermore, the antioxidative and anti-inflammatory effects of FS were found to benefit each other, but were independent. Thus, FS can be used as a component to manage epidermal inflammation due to its anti-inflammatory and anti-oxidative properties.<\/jats:p>","DOI":"10.3390\/molecules24173064","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T04:38:23Z","timestamp":1566794303000},"page":"3064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-2259","authenticated-orcid":false,"given":"Yuzhu","family":"He","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"},{"name":"Department of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-gook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-7179","authenticated-orcid":false,"given":"Hye-Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"},{"name":"Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0713-9000","authenticated-orcid":false,"given":"Qiaochu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"},{"name":"Department of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"},{"name":"Department of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ok-su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-1411","authenticated-orcid":false,"given":"Ok-joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"ref_1","first-page":"259","article-title":"The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice","volume":"5","author":"Mahboubi","year":"2016","journal-title":"World J. 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