{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:19Z","timestamp":1787029039582,"version":"build-2736575974"},"reference-count":68,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673561"],"award-info":[{"award-number":["81673561"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Natural Science Foundation of Fujian Province","award":["2017J01838"],"award-info":[{"award-number":["2017J01838"]}]},{"name":"the Research Fund of University of Macau","award":["MYRG2018-00165-ICMS"],"award-info":[{"award-number":["MYRG2018-00165-ICMS"]}]},{"name":"the Science and Technology Development Fund, Macao S.A.R","award":["176\/2017\/A3"],"award-info":[{"award-number":["176\/2017\/A3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Pien-Tze-Huang (PTH) is a famous and commonly used traditional Chinese medicine formula in China. It was first formulated by a royal physician of the Ming Dynasty (around 1555 AD). Recently, PTH has attracted attention worldwide due to its beneficial effects against various diseases, especially cancer. This paper systematically reviewed the up-to-date information on its chemical composition, pharmacology, and clinical application. A range of chemical compounds, mainly ginsenosides and bile acids, have been identified and quantified from PTH. Pharmacological studies indicated that PTH has beneficial effects against various cancers, hepatopathy, and ischemic stroke. Furthermore, PTH has been used clinically to treat various diseases in China, such as colorectal cancer, liver cancer, and hepatitis. In summary, PTH is a potential agent with extensive therapeutic effects for the treatment of various diseases. However, the lack of information on the side effects and toxicity of PTH is a non-negligible issue, which needs to be seriously studied in the future.<\/jats:p>","DOI":"10.3390\/molecules24183274","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T04:12:40Z","timestamp":1568002360000},"page":"3274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Therapeutic Potential of Pien-Tze-Huang: A Review on Its Chemical Composition, Pharmacology, and Clinical Application"],"prefix":"10.3390","volume":"24","author":[{"given":"Lili","family":"Huang","sequence":"first","affiliation":[{"name":"College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering Innovation Center of Marine Biological Resource Development and Utilization, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2853-1087","authenticated-orcid":false,"given":"Jinjian","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqing","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"ref_1","unstructured":"Commission, C.P. (2015). Pharmacopoeia of the People\u2019s Republic of China, Chinese Medical Science and Technology Press."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1034\/j.1600-0773.2002.910406.x","article-title":"Pien Tze Huang protects the liver against carbon tetrachloride-induced damage","volume":"91","author":"Lee","year":"2002","journal-title":"Pharm. Toxicol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1191\/0960327104ht414oa","article-title":"Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activities","volume":"23","author":"Chan","year":"2004","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_4","first-page":"4","article-title":"Clinical analysis of the effect of Pien Tze Huang in treatment of 42 patients with moderate or advanced liver cancer","volume":"12","author":"Xu","year":"1994","journal-title":"Shanghai J. Tradit. Chin. Med."},{"key":"ref_5","first-page":"23","article-title":"Preliminary Therapeutical observation of advanced colon cancer","volume":"15","author":"Gu","year":"1993","journal-title":"Chin. Tradit. Pat. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jpba.2015.02.028","article-title":"An integrated high resolution mass spectrometric data acquisition method for rapid screening of saponins in Panax notoginseng (Sanqi)","volume":"109","author":"Lai","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1248\/cpb.50.663","article-title":"Androstane alkaloids from musk of Moschus moschiferus","volume":"50","author":"Oh","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1039\/c2an36084e","article-title":"Multi-component analysis of bile acids in natural Calculus bovis and its substitutes by ultrasound-assisted solid-liquid extraction and UPLC-ELSD","volume":"137","author":"Kong","year":"2012","journal-title":"Analyst"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.chroma.2010.10.116","article-title":"Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: Simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry","volume":"1218","author":"Qiao","year":"2011","journal-title":"J. Chromatography. A"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jchromb.2016.05.021","article-title":"Identification and quantification of the anti-inflammatory constituents in Pian-Tze-Huang by liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometry","volume":"1027","author":"Huang","year":"2016","journal-title":"J. Chromatogr. Banalyt. Technol. Biomed. Life Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1002\/jssc.201300655","article-title":"Rapid simultaneous determination of twelve major components in Pien Tze Huang by ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry","volume":"36","author":"Huang","year":"2013","journal-title":"J. Sep. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10599","DOI":"10.1021\/jf402993a","article-title":"Influence of gastrointestinal digestion and edible plant combination on oral bioavailability of triterpene saponins, using a biomimetic digestion and absorption system and determination by HPLC","volume":"61","author":"Li","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jchromb.2017.07.033","article-title":"Simultaneous quantification six active compounds in rat plasma by UPLC-MS\/MS and its application to a pharmacokinetic study of Pien-Tze-Huang","volume":"1061\u20131062","author":"Xu","year":"2017","journal-title":"J. Chromatogr. Banalyt. Technol. Biomed. Life Sci."},{"key":"ref_14","first-page":"536","article-title":"The determination of ginsenosides Rg1 in Pien Tze Huang by thin-layer chromatography","volume":"28","author":"Pang","year":"1997","journal-title":"Chin. Herb. Med."},{"key":"ref_15","first-page":"1906","article-title":"Determination of Three Compounds in Pien Tze Huang by HPLC","volume":"43","author":"Lai","year":"2008","journal-title":"Chin. Pharm. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1124\/jpet.114.218750","article-title":"Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation","volume":"352","author":"Zhang","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/tox.22616","article-title":"Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in mice","volume":"33","author":"Ning","year":"2018","journal-title":"Environ. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.fct.2012.02.035","article-title":"Inhibition of inflammations and macrophage activation by ginsenoside-Re isolated from Korean ginseng (Panax ginseng C.A. Meyer)","volume":"50","author":"Paul","year":"2012","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1021\/jf5000776","article-title":"Anticarcinogenic effects of products of heat-processed ginsenoside Re, a major constituent of ginseng berry, on human gastric cancer cells","volume":"62","author":"Jang","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5142\/jgr.2013.37.283","article-title":"Ginsenoside-Re ameliorates ischemia and reperfusion injury in the heart: A hemodynamics approach","volume":"37","author":"Lim","year":"2013","journal-title":"J. Ginseng Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000455154","article-title":"Muscone Induces CYP1A2 and CYP3A4 Enzyme Expression in L02 Human Liver Cells and CYP1A2 and CYP3A11 Enzyme Expression in Kunming Mice","volume":"99","author":"Liu","year":"2017","journal-title":"Pharmacology"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Fernandez-Moriano, C., Gonzalez-Burgos, E., Iglesias, I., Lozano, R., and Gomez-Serranillos, M.P. (2017). Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182933"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"015101","DOI":"10.1088\/0957-4484\/28\/1\/015101","article-title":"Carbon nanotubes as carriers of Panax ginseng metabolites and enhancers of ginsenosides Rb1 and Rg1 anti-cancer activity","volume":"28","author":"Lahiani","year":"2017","journal-title":"Nanotechnology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00702-003-0063-1","article-title":"Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP+-affected mesencephalic dopaminergic cells","volume":"111","author":"Radad","year":"2004","journal-title":"J. Neural Transm. (Vienna Austria 1996)"},{"key":"ref_25","first-page":"4235","article-title":"Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-kappaB and NLRP3 inflammasome","volume":"10","author":"Du","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3892\/ol.2012.811","article-title":"Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1\/S cell cycle progression","volume":"4","author":"Shen","year":"2012","journal-title":"Oncol. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1007\/s11999-009-1079-0","article-title":"Muscone protects vertebral end-plate degeneration by antiinflammatory property","volume":"468","author":"Liang","year":"2010","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jep.2012.10.007","article-title":"Chronic toxicity of ginsenoside Re on Sprague-Dawley rats","volume":"144","author":"Lu","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_29","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA: A Cancer J. Clin."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s11655-011-0846-4","article-title":"Pien Tze Huang induced apoptosis in human colon cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation of caspase 3","volume":"17","author":"Lin","year":"2011","journal-title":"Chin. J. Integr. Med."},{"key":"ref_31","first-page":"1569","article-title":"Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model","volume":"40","author":"Zhuang","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.3892\/or.2012.2067","article-title":"Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3","volume":"28","author":"Shen","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.3892\/etm.2017.4972","article-title":"Pien Tze Huang inhibits the proliferation of colorectal cancer cells by increasing the expression of miR-34c-5p","volume":"14","author":"Wan","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"679436","DOI":"10.1155\/2014\/679436","article-title":"Pien Tze Huang Overcomes Multidrug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells via Suppression of TGF-beta Pathway","volume":"2014","author":"Shen","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.3892\/etm.2017.4951","article-title":"Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression","volume":"14","author":"Chen","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.3892\/etm.2017.4755","article-title":"Pien Tze Huang alleviates 5-fluorouracil-induced intestinal mucositis in CT-26 tumor-bearing mice","volume":"14","author":"Fu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_37","first-page":"8","article-title":"Clinical observation of Pien Tze Huang combined with chemotherapy in the treatment of advacnced colon cancer","volume":"43","author":"Lin","year":"2012","journal-title":"Fujian J. TCM Fubruary"},{"key":"ref_38","first-page":"30","article-title":"Clinical observation of Pien Tze Huang combined with XELOX chemotherapy regimen in the treatment of advacnced colon cancer","volume":"45","author":"Huang","year":"2014","journal-title":"Fujian J. TCM Fubruary"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11655-012-1121-z","article-title":"Effects of Pien Tze Huang on angiogenesis in vivo and in vitro","volume":"18","author":"Shen","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Li, L., Shen, A., Chu, J., Sferra, T.J., Sankararaman, S., Ke, X., Chen, Y., and Peng, J. (2018). Pien Tze Huang ameliorates DSS-induced colonic inflammation in a mouse colitis model through inhibition of the IL-6\/STAT3 pathway. Mol. Med. Rep., 1113\u20131119.","DOI":"10.3892\/mmr.2018.9051"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3892\/ijo.2014.2772","article-title":"Pien Tze Huang inhibits metastasis of human colorectal carcinoma cells via modulation of TGF-beta1\/ZEB\/miR-200 signaling network","volume":"46","author":"Shen","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.3892\/or.2015.3784","article-title":"Pien Tze Huang inhibits liver metastasis by targeting TGF-beta signaling in an orthotopic model of colorectal cancer","volume":"33","author":"Lin","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3892\/etm.2014.1549","article-title":"Pien Tze Huang inhibits hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells through suppression of the HIF-1 pathway","volume":"7","author":"Chen","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.3892\/or.2016.5186","article-title":"Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer","volume":"36","author":"Lin","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_45","first-page":"454279","article-title":"Pien Tze Huang Inhibits Hypoxia-Induced Angiogenesis via HIF-1 alpha \/VEGF-A Pathway in Colorectal Cancer","volume":"2015","author":"Chen","year":"2015","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.3892\/or.2013.2609","article-title":"Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways","volume":"30","author":"Shen","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3892\/mmr.2013.1760","article-title":"Pien Tze Huang suppresses the stem-like side population in colorectal cancer cells","volume":"9","author":"Wei","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3892\/or.2015.4378","article-title":"Pien Tze Huang inhibits the proliferation, and induces the apoptosis and differentiation of colorectal cancer stem cells via suppression of the Notch1 pathway","volume":"35","author":"Qi","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_49","first-page":"27","article-title":"Effects of pien tze huang on proliferation and apoptosis of liver cancer stem cells","volume":"48","author":"Wei","year":"2017","journal-title":"Fujian J. TCM"},{"key":"ref_50","first-page":"171","article-title":"Study on antitumor effect of Pien Tze Huang in vitro","volume":"34","author":"Guo","year":"2011","journal-title":"Drug Eval. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Fu, Y., Zhang, L., Hong, Z., Zheng, H., Li, N., Gao, H., Chen, B., and Zhao, Y. (2016). Methanolic Extract of Pien Tze Huang Induces Apoptosis Signaling in Human Osteosarcoma MG63 Cells via Multiple Pathways. Molecules, 21.","DOI":"10.3390\/molecules21030283"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/s11655-014-1766-x","article-title":"Effect of p27 gene combined with Pientzehuang on tumor growth in osteosarcoma-bearing nude mice","volume":"21","author":"Ren","year":"2015","journal-title":"Chin. J. Integr. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3892\/or.2013.2916","article-title":"Pien Tze Huang induces apoptosis in multi-drugresistant U2OS\/ADM cells via downregulation of Bcl2, survivin and P-gp and upregulation of Bax","volume":"31","author":"Zhang","year":"2014","journal-title":"Oncology reports"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/00207450802324770","article-title":"Pien Tze Huang, a composite Chinese traditional herbal extract, affects survival of neuroblastoma cells","volume":"119","author":"Lu","year":"2009","journal-title":"Int. J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.3892\/ol.2014.1989","article-title":"Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway","volume":"7","author":"He","year":"2014","journal-title":"Oncol. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Chen, X., Qi, F., Shen, A.L., Chu, J.F., Sferra, T.J., Chen, Y.Q., and Peng, J. (2018). Pien Tze Huang Overcomes Doxorubicin Resistance and Inhibits Epithelial-Mesenchymal Transition in MCF-7\/ADR Cells. Chin. J. Integr. Med.","DOI":"10.1007\/s11655-018-2992-4"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.acthis.2018.06.006","article-title":"Pien Tze Huang ameliorates liver injury by inhibiting the PERK\/eIF2alpha signaling pathway in alcohol and high-fat diet rats","volume":"120","author":"Yang","year":"2018","journal-title":"Acta Histochem."},{"key":"ref_58","first-page":"124","article-title":"Effect Study of Pien Tze Huang on nonalcoholic fatty liver disease in rats","volume":"21","author":"Deng","year":"2015","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Zhang, L., Lam, W., L\u00fc, L., Wang, C., Wong, Y., Lam, L., Tang, H., Wai, M., Wang, M., and Kwong, W. (2010). Protective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke. Chin. Med., 5.","DOI":"10.1186\/1749-8546-5-35"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.2174\/092986711796642535","article-title":"How Would Composite Traditional Chinese Medicine Protect the Brain\u2014An Example of the Composite Formula \u201cPien Tze Huang\u201d","volume":"18","author":"Zhang","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jep.2018.03.018","article-title":"Pien-Tze-Huang protects cerebral ischemic injury by inhibiting neuronal apoptosis in acute ischemic stroke rats","volume":"219","author":"Zhang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_62","unstructured":"Xu, Y.Y., and Yu, E.X. (1994). Clinical analysis of 42 cases of advanced liver cancer treated with Pien Tze Huang. Shanghai J. Tradit. Chin. Med., 4\u20135."},{"key":"ref_63","unstructured":"Zhao, S.L., and Pan, J. (2006). A clinical trial of combined use of Pien Tze Huang and chemotherapy in the treatment of primary liver cancer. Med. World, 49\u201351."},{"key":"ref_64","first-page":"31","article-title":"Clinical observation of the changes of immune indexes of primary liver cancer treated with Pien Tze Huang and TACE","volume":"1","author":"Meng","year":"2008","journal-title":"Jiu Jiang Med. J."},{"key":"ref_65","first-page":"1290","article-title":"Clinical study of Pien tze huang in treatment of chronic hepatitis B","volume":"26","author":"Zhong","year":"2017","journal-title":"Chin. J. Gastroenterol. Hepatol."},{"key":"ref_66","first-page":"780","article-title":"Clinical study of Pianzaihuang in the treatment of recurrent aphthous ulcer","volume":"31","author":"He","year":"2015","journal-title":"Chin J. Clin. Pharm."},{"key":"ref_67","first-page":"21","article-title":"Clinical observation of Pianzaihuang in the treatment of recurrent aphthous ulcer","volume":"27","author":"Lin","year":"2017","journal-title":"Shenzheng J. Integr. Med."},{"key":"ref_68","first-page":"94","article-title":"Clinical observation of Pien Tze Huang in the treatment of phlebitis induced by amiodarone","volume":"3","author":"Lian","year":"2012","journal-title":"Today Nurse"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/18\/3274\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:17:50Z","timestamp":1760188670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/18\/3274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,9]]},"references-count":68,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["molecules24183274"],"URL":"https:\/\/doi.org\/10.3390\/molecules24183274","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,9]]}}}