{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:33:20Z","timestamp":1787564000774,"version":"build-2736575974"},"reference-count":21,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taiwan Ministry of Health and Welfare Clinical Trial Center","award":["MOHW107-TDU-B-212-123004"],"award-info":[{"award-number":["MOHW107-TDU-B-212-123004"]}]},{"name":"Ministry of Education in Taiwan","award":["CMRC-CHM-4"],"award-info":[{"award-number":["CMRC-CHM-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Phytochemical investigation of the whole plant of Tradescantia albiflora Kunth led to the isolation and characterization of a butanolide, rosmarinosin B (1), that was isolated from natural sources for the first time, a new butenolide, 5-O-acetyl bracteanolide A (2), and a new apocarotenoid, 2\u03b2-hydroxyisololiolide (11), together with 25 known compounds (compounds 3\u201310 and 12\u201328). The structures of the new compounds were elucidated by analysis of their spectroscopic data, including MS, 1D, and 2D NMR experiments, and comparison with literature data of known compounds. Furthermore, four butenolides 4a\u20134d were synthesized as novel derivatives of bracteanolide A. The isolates and the synthesized derivatives were evaluated for their preliminary anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production in RAW 264.7 cells. Among them, the synthesized butenolide derivative n-butyl bracteanolide A (4d) showed enhanced NO inhibitory activity compared to the original compound, with an IC50 value of 4.32 \u00b1 0.09 \u03bcg\/mL.<\/jats:p>","DOI":"10.3390\/molecules24183336","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T10:32:41Z","timestamp":1568370761000},"page":"3336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Phytochemical Investigation of Tradescantia Albiflora and Anti-Inflammatory Butenolide Derivatives"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-4082","authenticated-orcid":false,"given":"Ping-Chen","family":"Tu","sequence":"first","affiliation":[{"name":"The Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Chun","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Taiwan University, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chia","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Jhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1408-6004","authenticated-orcid":false,"given":"Te-Ling","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Medical University, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Fu","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung 413, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5935-6755","authenticated-orcid":false,"given":"Yueh-Hsiung","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan"},{"name":"Department of Biotechnology, Asia University, Taichung 413, Taiwan"},{"name":"Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S223","DOI":"10.4103\/0973-1296.182171","article-title":"Phytochemicals from Tradescantia albiflora Kunth extracts reduce serum uric acid levels in oxonate-induced rats","volume":"12","author":"Wang","year":"2016","journal-title":"Pharm. 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