{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:20:04Z","timestamp":1781295604179,"version":"3.54.1"},"reference-count":40,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51373131"],"award-info":[{"award-number":["51373131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Talent Project of Southwest University","award":["SWU115034"],"award-info":[{"award-number":["SWU115034"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFD0800604"],"award-info":[{"award-number":["2018YFD0800604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ralstonia solanacearum (R. solanacearum)-induced bacterial wilt of the nightshade family causes a great loss in agricultural production annually. Although there has been some efficient pesticides against R. solanacearum, inaccurate pesticide releasing according to the onset time of bacterial wilt during the use of pesticides still hinders the disease management efficiency. Herein, on the basis of the soil pH change during R. solanacearum growth, and pH sensitivity of the Schiff base structure, a pH-sensitive oxidized alginate-based double-crosslinked gel was fabricated as a pesticide carrier. The gel was prepared by crosslinking oxidized sodium alginate (OSA) via adipic dihydrazide (ADH) and Ca2+. After loading tetramycin into the gel, it showed a pH-dependent pesticide releasing behavior and anti-bacterial activity against R. solanacearum. Further study also showed that the inhibition rate of the tetramycin-loaded gel was higher than that of industrial pesticide difenoconazole. This work aimed to reduce the difficulty of pesticide administration in the high incidence period of bacterial wilt and we believe it has a great application potential in nightshade production.<\/jats:p>","DOI":"10.3390\/molecules24193606","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T10:05:12Z","timestamp":1570442712000},"page":"3606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Fabrication of pH-Sensitive Tetramycin Releasing Gel and Its Antibacterial Bioactivity against Ralstonia solanacearum"],"prefix":"10.3390","volume":"24","author":[{"given":"Xiaozhou","family":"Ma","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China"},{"name":"Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunyu","family":"Xiang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing 400715 China"},{"name":"College of Plant Protection, State Cultivation Base of Crop Stress Biology for Southern Mountainous Land, Southwest University, Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Plant Protection, State Cultivation Base of Crop Stress Biology for Southern Mountainous Land, Southwest University, Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhai","family":"He","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianchao","family":"Sun","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing 400715 China"},{"name":"College of Plant Protection, State Cultivation Base of Crop Stress Biology for Southern Mountainous Land, Southwest University, Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2214-6812","authenticated-orcid":false,"given":"Yongqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing 400715 China"},{"name":"College of Plant Protection, State Cultivation Base of Crop Stress Biology for Southern Mountainous Land, Southwest University, Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0648-2525","authenticated-orcid":false,"given":"Jin","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China"},{"name":"Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/mpp.12038","article-title":"Ralstonia solanacearum, a widespread bacterial plant pathogen in the post-genomic era","volume":"14","author":"Peeters","year":"2013","journal-title":"Mol. 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