{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:22Z","timestamp":1787029042858,"version":"build-2736575974"},"reference-count":47,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The work reports the use of polyamidoamine dendrimers (PAMAM) and a cross-linking agent, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide\/N-hydroxysuccinimide (EDC\/NHS) or 4-(4,6-dimethoxy[1,3,5]triazin-2-yl)-4-methyl-morpholinium chloride (DMTMM), for the thermal stabilization of dermal bovine collagen. The efficiency of EDC\/NHS\/PAMAM and DMTMM\/PAMAM in the cross-linking of collagen is correlated to the increase of the collagen shrinkage temperature (Ts), measured by differential scanning calorimetry (DSC). An alternative enzymatic protocol was adopted to measure the degradability of EDC\/NHS\/PAMAM tanned hides; these data are correlated to the thermal stability values measured by DSC. In the presence of PAMAMs, EDC\/NHS provides very high stabilization of bovine dermal collagen, giving Ts of up to 95 \u00b0C, while DMTMM achieves lower stabilization. Preliminary tanning tests carried out in best reaction conditions show that EDC\/NHS\/PAMAM could be an interesting, environmentally-sustainable tanning system which is completely free of metals, formaldehyde, and phenols. Two new unreported dendrimeric species were synthesized and employed.<\/jats:p>","DOI":"10.3390\/molecules24193611","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T10:05:12Z","timestamp":1570442712000},"page":"3611","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Polyamidoamide Dendrimers and Cross-Linking Agents for Stabilized Bioenzymatic Resistant Metal-Free Bovine Collagen"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8799-210X","authenticated-orcid":false,"given":"Valentina","family":"Beghetto","sequence":"first","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari Venice, Via Torino 155, 30172 Mestre (Venice), Italy"},{"name":"Crossing Ltd., Viale della Repubblica 193\/b, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-2974","authenticated-orcid":false,"given":"Vanessa","family":"Gatto","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari Venice, Via Torino 155, 30172 Mestre (Venice), Italy"},{"name":"Crossing Ltd., Viale della Repubblica 193\/b, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-6592","authenticated-orcid":false,"given":"Silvia","family":"Conca","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari Venice, Via Torino 155, 30172 Mestre (Venice), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1786-7295","authenticated-orcid":false,"given":"Noemi","family":"Bardella","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari Venice, Via Torino 155, 30172 Mestre (Venice), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5751-879X","authenticated-orcid":false,"given":"Alberto","family":"Scrivanti","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari Venice, Via Torino 155, 30172 Mestre (Venice), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"ref_1","unstructured":"Black, M., Canova, M., Rydin, S., Scalet, B.M., Roudier, S., and Sancho, D.L. 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