{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:56:55Z","timestamp":1790992615776,"version":"4.1.0"},"reference-count":161,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The genus Erythroxylum contains species used by indigenous people of South America long before the domestication of plants. Two species, E. coca and E. novogranatense, have been utilized for thousands of years specifically for their tropane alkaloid content. While abuse of the narcotic cocaine has impacted society on many levels, these species and their wild relatives contain untapped resources for the benefit of mankind in the form of foods, pharmaceuticals, phytotherapeutic products, and other high-value plant-derived metabolites. In this review, we describe the current state of knowledge of members within the genus and the recent advances in the realm of molecular biology and biochemistry.<\/jats:p>","DOI":"10.3390\/molecules24203788","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T11:37:55Z","timestamp":1571657875000},"page":"3788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Erythroxylum in Focus: An Interdisciplinary Review of an Overlooked Genus"],"prefix":"10.3390","volume":"24","author":[{"given":"David A.","family":"Restrepo","sequence":"first","affiliation":[{"name":"Centro de Estudios sobre Seguridad y Drogas, Facultad de Econom\u00eda, Universidad de los Andes, Bogota 111711, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Saenz","sequence":"additional","affiliation":[{"name":"Departamento Ciencias Biol\u00f3gicas, Facultad de Ciencias, Universidad de los Andes, Bogota 111711, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando Adolfo","family":"Jara-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Jard\u00edn Bot\u00e1nico de Bogot\u00e1 Jos\u00e9 Celestino Mutis, Bogota 111071, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-6680","authenticated-orcid":false,"given":"Iv\u00e1n F.","family":"Calixto-Bot\u00eda","sequence":"additional","affiliation":[{"name":"CEMarin student, Escuela de Biolog\u00eda, Universidad Pedag\u00f3gica y Tecnol\u00f3gica de Colombia, Tunja 150003, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sioly","family":"Rodr\u00edguez-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Centro de Estudios sobre Seguridad y Drogas, Facultad de Econom\u00eda, Universidad de los Andes, Bogota 111711, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Zuleta","sequence":"additional","affiliation":[{"name":"Centro de Estudios sobre Seguridad y Drogas, Facultad de Econom\u00eda, Universidad de los Andes, Bogota 111711, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin G.","family":"Chavez","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), 06466 Gatersleben, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Centro de Estudios sobre Seguridad y Drogas, Facultad de Econom\u00eda, Universidad de los Andes, Bogota 111711, Colombia"},{"name":"Departamento Ciencias Biol\u00f3gicas, Facultad de Ciencias, Universidad de los Andes, Bogota 111711, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4865-3938","authenticated-orcid":false,"given":"John C.","family":"D\u2019Auria","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), 06466 Gatersleben, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1016\/j.ejmech.2011.07.057","article-title":"Natural Products: An Evolving Role In Future Drug Discovery","volume":"46","author":"Mishra","year":"2011","journal-title":"Eur. 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