{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:13:44Z","timestamp":1790817224024,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2015-65113-C2-1-R"],"award-info":[{"award-number":["SAF2015-65113-C2-1-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2015-65113-C2-2-R"],"award-info":[{"award-number":["SAF2015-65113-C2-2-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RTI2018-094356-B-C21"],"award-info":[{"award-number":["RTI2018-094356-B-C21"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007757","name":"Agencia Canaria de Investigaci\u00f3n, Innovaci\u00f3n y Sociedad de la Informaci\u00f3n","doi-asserted-by":"publisher","award":["ProID 2017010071"],"award-info":[{"award-number":["ProID 2017010071"]}],"id":[{"id":"10.13039\/501100007757","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A series of 34 1,2,3-triazole-naphthoquinone conjugates were synthesized via copper-catalyzed cycloaddition (CuAAC). They were evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and against three different tumor cell lines (SKBr-3, MCF-7, HEL). The most active antimalarial compounds showed a low antiproliferative activity. Simplified analogues were also obtained and some structure\u2013activity relationships were outlined. The best activity was obtained by compounds 3s and 3j, having IC50 of 0.8 and 1.2 \u03bcM, respectively. Molecular dockings were also carried on Plasmodium falciparum enzyme dihydroorotate dehydrogenase (PfDHODH) in order to rationalize the results.<\/jats:p>","DOI":"10.3390\/molecules24213917","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T05:18:26Z","timestamp":1572499106000},"page":"3917","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates"],"prefix":"10.3390","volume":"24","author":[{"given":"Sandra","family":"Oramas-Royo","sequence":"first","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica (CIBICAN), Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, 38206 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"L\u00f3pez-Rojas","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica (CIBICAN), Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, 38206 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Amesty","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica (CIBICAN), Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, 38206 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones F\u00e1rmaco Bioqu\u00edmicas, Facultad de Ciencias Farmac\u00e9uticas y Bioqu\u00edmicas, Universidad Mayor de San Andr\u00e9s, Av. 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Saavedra 2024, 2\u00b0 piso, Miraflores, La Paz 2314, Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mart\u00edn-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Investigaciones Biom\u00e9dicas y Sanitarias (IUIBS), Departamento de Ciencias Cl\u00ednicas, BIOPHARM, Universidad de Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-465X","authenticated-orcid":false,"given":"Leandro","family":"Fern\u00e1ndez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Investigaciones Biom\u00e9dicas y Sanitarias (IUIBS), Departamento de Ciencias Cl\u00ednicas, BIOPHARM, Universidad de Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-7099","authenticated-orcid":false,"given":"Ana","family":"Est\u00e9vez-Braun","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica (CIBICAN), Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, 38206 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"ref_1","unstructured":"(2019, October 07). 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