{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:12:38Z","timestamp":1788250358436,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Based on medicinal chemistry tools, new compounds for malaria treatment were designed. The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine, amodiaquine, mefloquine and sulfadoxine, were used as inspiration. We demonstrated the importance of quinoline and non-quinoline derivatives in vitro with activity against the W2 chloroquine-resistant (CQR) Plasmodium falciparum clone strain and in vivo against Plasmodium berghei-infected mouse model. Among the quinoline derivatives, new hybrids between chloroquine and sulfadoxine were designed, which gave rise to an important prototype that was more active than both chloroquine and sulfadoxine. Hybrids between chloroquine\u2013atorvastatin and primaquine\u2013atorvastatin were also synthesized and shown to be more potent than the parent drugs alone. Additionally, among the quinoline derivatives, new mefloquine derivatives were synthesized. Among the non-quinoline derivatives, we obtained excellent results with the triazolopyrimidine nucleus, which gave us prototype I that inspired the synthesis of new heterocycles. The pyrazolopyrimidine derivatives stood out as non-quinoline derivatives that are potent inhibitors of the P. falciparum dihydroorotate dehydrogenase (PfDHODH) enzyme. We also examined the pyrazolopyridine and pyrazolopyrimidine nuclei.<\/jats:p>","DOI":"10.3390\/molecules24224095","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T09:11:27Z","timestamp":1573636287000},"page":"4095","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["The Development of Novel Compounds Against Malaria: Quinolines, Triazolpyridines, Pyrazolopyridines and Pyrazolopyrimidines"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6398-7717","authenticated-orcid":false,"given":"Luiz","family":"C. S. Pinheiro","sequence":"first","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos, Instituto de Tecnologia em F\u00e1rmacos, Farmanguinhos-FIOCRUZ, Funda\u00e7\u00e3o Oswaldo Cruz, Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro 21041-250, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia","family":"M. Feitosa","sequence":"additional","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos, Instituto de Tecnologia em F\u00e1rmacos, Farmanguinhos-FIOCRUZ, Funda\u00e7\u00e3o Oswaldo Cruz, Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro 21041-250, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia e Qu\u00edmica Medicinal, PPGFQM, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21041-250, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia","family":"O. Gandi","sequence":"additional","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos, Instituto de Tecnologia em F\u00e1rmacos, Farmanguinhos-FIOCRUZ, Funda\u00e7\u00e3o Oswaldo Cruz, Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro 21041-250, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia e Qu\u00edmica Medicinal, PPGFQM, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21041-250, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via","family":"F. Silveira","sequence":"additional","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos, Instituto de Tecnologia em F\u00e1rmacos, Farmanguinhos-FIOCRUZ, Funda\u00e7\u00e3o Oswaldo Cruz, Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro 21041-250, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica, PGQu Instituto de Qu\u00edmica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21041-250, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nubia","family":"Boechat","sequence":"additional","affiliation":[{"name":"Departamento de S\u00edntese de F\u00e1rmacos, Instituto de Tecnologia em F\u00e1rmacos, Farmanguinhos-FIOCRUZ, Funda\u00e7\u00e3o Oswaldo Cruz, Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro 21041-250, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia e Qu\u00edmica Medicinal, PPGFQM, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21041-250, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica, PGQu Instituto de Qu\u00edmica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21041-250, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2019, July 06). 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