{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:20:08Z","timestamp":1767968408925,"version":"3.49.0"},"reference-count":37,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Natural Science Foundation of China","award":["2016GXNSFAA380323, 2018GXNSFAA138165, 2018GXNSFAA281200"],"award-info":[{"award-number":["2016GXNSFAA380323, 2018GXNSFAA138165, 2018GXNSFAA281200"]}]},{"name":"Key R &amp; D Project for Science Research and Technology Development of Guilin","award":["GZWBXKF2016006, 20170108-10"],"award-info":[{"award-number":["GZWBXKF2016006, 20170108-10"]}]},{"name":"he open fund of the Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation","award":["2018KF010"],"award-info":[{"award-number":["2018KF010"]}]},{"name":"the Open Fund of Guangxi Key Laboratory of Chemistry and Engineering of forest Products","award":["GXFC18-02"],"award-info":[{"award-number":["GXFC18-02"]}]},{"name":"he Youth Promotion Project Fund of Guangxi","award":["2019KY0551"],"award-info":[{"award-number":["2019KY0551"]}]},{"name":"the Project to Improve the Basic Research Ability of Middle and Young Teachers in Guilin Medical University","award":["2018glmcy015"],"award-info":[{"award-number":["2018glmcy015"]}]},{"name":"he Open Fund of State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources","award":["CMEMR2019-B02"],"award-info":[{"award-number":["CMEMR2019-B02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>To discover novel potent cytotoxic diterpenoids, a series of hybrids of dehydroabietic acid containing 1,2,3-triazole moiety were designed and synthesized. The target compounds were characterized by means of FT-IR, 1H NMR, 13C NMR, ESI-MS and elemental analysis techniques. The in vitro cytotoxicity of these compounds was evaluated by standard MTT (methyl thiazolytetrazolium) assay against CNE-2 (nasopharynx), HepG2 (liver), HeLa (epithelial cervical), BEL-7402 (liver) human carcinoma cell lines and human normal liver cell (HL-7702). The screening results revealed that most of the hybrids showed significantly improved cytotoxicity over parent compound DHAA. Among them, [1-(3-fluorobenzyl)-1H-1,2,3-triazole-4-yl]dehydroabietic acid methyl ester (3c), and [1-(2-nitrobenzyl)-1H-1,2,3-triazole-4-yl]dehydroabietic acid methyl ester (3k) displayed better antiproliferative activity with IC50 (50% inhibitory concentration) values of 5.90 \u00b1 0.41 and 6.25 \u00b1 0.37 \u00b5M toward HepG2 cells compared to cisplatin, while they exhibited lower cytotoxicity against HL-7702. Therefore, the 1,2,3-triazole-hybrids could be a promising strategy for the synthesis of antitumor diterpenoids and it also proved the essential role of 1,2,3-triazole moiety of DHAA in the biological activity.<\/jats:p>","DOI":"10.3390\/molecules24224191","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T11:30:17Z","timestamp":1574163017000},"page":"4191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Synthesis and Antiproliferative Evaluation of Novel Hybrids of Dehydroabietic Acid Bearing 1,2,3-Triazole Moiety"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-4531","authenticated-orcid":false,"given":"Fang-Yao","family":"Li","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"},{"name":"College of Pharmacy, Guilin Medical University, Guilin 541100, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guilin Medical University, Guilin 541100, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guilin Medical University, Guilin 541100, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Li","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guilin Medical University, Guilin 541100, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-Na","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guilin Medical University, Guilin 541100, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Qun","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Humanities and Management, Guilin Medical University, Guilin 541100, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Gui","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Hou","family":"Lei","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Nangning, Guangxi 530006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.fitote.2016.07.002","article-title":"Synthesis and cytotoxicity evaluation of 4\u2032-amino-4\u2032-dehydroxyloleandrin derivatives","volume":"113","author":"Chen","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejmech.2019.01.017","article-title":"Quinolone hybrids and their anti-cancer activities: An overview","volume":"165","author":"Gao","year":"2019","journal-title":"Eur. 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