{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:43:48Z","timestamp":1773103428272,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>N-mercaptoalkylglycine residues were inserted into peptides by reacting N-free amino groups of peptides, which were initially synthesized on 2-chlorotrityl resin (Cltr) using the Fmoc\/tBu method, with bromoacetic acid and subsequent nucleophilic replacement of the bromide by reacting with S-4-methoxytrityl- (Mmt)\/S-trityl- (Trt) protected aminothiols. The synthesized thiols containing peptide\u2013peptoid hybrids were cleaved from the resin, either protected by treatment with dichloromethane (DCM)\/trifluoroethanol (TFE)\/acetic acid (AcOH) (7:2:1), or deprotected (fully or partially) by treatment with trifluoroacetic acid (TFA) solution using triethylsilane (TES) as a scavenger.<\/jats:p>","DOI":"10.3390\/molecules24234261","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T09:02:52Z","timestamp":1574413372000},"page":"4261","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Solid-Phase Insertion of N-mercaptoalkylglycine Residues into Peptides"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1204-1574","authenticated-orcid":false,"given":"Spyridon","family":"Mourtas","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Patras, 26510 Rio Patras, Greece"},{"name":"Institute of Chemical Engineering Sciences of the Foundation for Research and Technology Hellas (FORTH\/IEC-HT), 26504 Rio Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Gatos","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Patras, 26510 Rio Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleomenis","family":"Barlos","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Patras, 26510 Rio Patras, Greece"},{"name":"CBL-Patras, Patras Industrial Area, Block 1, 25018 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/anie.201205674","article-title":"N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions","volume":"52","author":"Chatterjee","year":"2013","journal-title":"Angew. 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