{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:03:08Z","timestamp":1790902988524,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","award":["201780I027"],"award-info":[{"award-number":["201780I027"]}],"id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["J\u00e1nos Bolyai Research Scholarship"],"award-info":[{"award-number":["J\u00e1nos Bolyai Research Scholarship"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State of Hungary","award":["T\u00c1MOP 4.2.4. A\/2-11-1-2012-000"],"award-info":[{"award-number":["T\u00c1MOP 4.2.4. A\/2-11-1-2012-000"]}]},{"name":"Ministry of Human Capacities of Hungary","award":["New National Excellence Program (\u00daNKP-18-3)"],"award-info":[{"award-number":["New National Excellence Program (\u00daNKP-18-3)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Selenoesters and the selenium isostere of phthalic anhydride are bioactive selenium compounds with a reported promising activity in cancer, both due to their cytotoxicity and capacity to reverse multidrug resistance. Herein we evaluate the antiviral, the biofilm inhibitory, the antibacterial and the antifungal activities of these compounds. The selenoanhydride and 7 out of the 10 selenoesters were especially potent antiviral agents in Vero cells infected with herpes simplex virus-2 (HSV-2). In addition, the tested selenium derivatives showed interesting antibiofilm activity against Staphylococcus aureus and Salmonella enterica serovar Typhimurium, as well as a moderate antifungal activity in resistant strains of Candida spp. They were inactive against anaerobes, which may indicate that the mechanism of action of these derivatives depends on the presence of oxygen. The capacity to inhibit the bacterial biofilm can be of particular interest in the treatment of nosocomial infections and in the coating of surfaces of prostheses. Finally, the potent antiviral activity observed converts these selenium derivatives into promising antiviral agents with potential medical applications.<\/jats:p>","DOI":"10.3390\/molecules24234264","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T10:42:40Z","timestamp":1574419360000},"page":"4264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and Selenoanhydrides"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-388X","authenticated-orcid":false,"given":"Gabriella","family":"Spengler","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annam\u00e1ria","family":"Kincses","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00edmea","family":"Mosolyg\u00f3","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-801X","authenticated-orcid":false,"given":"Ma\u0142gorzata Anna","family":"Mar\u0107","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Nov\u00e9","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-0365","authenticated-orcid":false,"given":"M\u00e1ri\u00f3","family":"Gajd\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, E\u00f6tv\u00f6s Utca 6, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Sanmart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"McNeil","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-4253","authenticated-orcid":false,"given":"Jessica M.A.","family":"Blair","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2655-1575","authenticated-orcid":false,"given":"Enrique","family":"Dom\u00ednguez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General (IQOG-CSIC), Consejo Superior de Investigaciones Cient\u00edficas, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00705-016-3130-2","article-title":"Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections","volume":"162","author":"Li","year":"2017","journal-title":"Arch. 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