{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:10:45Z","timestamp":1790719845672,"version":"4.1.0"},"reference-count":104,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dinucleoside 5\u2032,5\u2032-polyphosphates (DNPs) are endogenous substances that play important intra- and extracellular roles in various biological processes, such as cell proliferation, regulation of enzymes, neurotransmission, platelet disaggregation and modulation of vascular tone. Various methodologies have been developed over the past fifty years to access these compounds, involving enzymatic processes or chemical procedures based either on P(III) or P(V) chemistry. Both solution-phase and solid-support strategies have been developed and are reported here. Recently, green chemistry approaches have emerged, offering attracting alternatives. This review outlines the main synthetic pathways for the preparation of dinucleoside 5\u2032,5\u2032-polyphosphates, focusing on pharmacologically relevant compounds, and highlighting recent advances.<\/jats:p>","DOI":"10.3390\/molecules24234334","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T03:55:51Z","timestamp":1574826951000},"page":"4334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthetic Strategies for Dinucleotides Synthesis"],"prefix":"10.3390","volume":"24","author":[{"given":"Lucie","family":"Appy","sequence":"first","affiliation":[{"name":"Nucleosides &amp; Phosphorylated Effectors, Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS, Universit\u00e9 de Montpellier, ENSCM, Campus Triolet, cc 1705, Place Eug\u00e8ne Bataillon, CEDEX 5, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystalle","family":"Chardet","sequence":"additional","affiliation":[{"name":"Nucleosides &amp; Phosphorylated Effectors, Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS, Universit\u00e9 de Montpellier, ENSCM, Campus Triolet, cc 1705, Place Eug\u00e8ne Bataillon, CEDEX 5, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1705-0576","authenticated-orcid":false,"given":"Suzanne","family":"Peyrottes","sequence":"additional","affiliation":[{"name":"Nucleosides &amp; Phosphorylated Effectors, Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS, Universit\u00e9 de Montpellier, ENSCM, Campus Triolet, cc 1705, Place Eug\u00e8ne Bataillon, CEDEX 5, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-578X","authenticated-orcid":false,"given":"B\u00e9atrice","family":"Roy","sequence":"additional","affiliation":[{"name":"Nucleosides &amp; Phosphorylated Effectors, Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS, Universit\u00e9 de Montpellier, ENSCM, Campus Triolet, cc 1705, Place Eug\u00e8ne Bataillon, CEDEX 5, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7854","DOI":"10.1021\/acs.chemrev.6b00174","article-title":"Recent trends in nucleotide synthesis","volume":"116","author":"Roy","year":"2016","journal-title":"Chem. 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