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In vitro cytotoxicity assay was used to monitor the antiproliferative activities against tumor cells. Absorption spectroscopy, fluorescence titration, circular dichroism spectroscopy, and molecular modeling studied the DNA interactions. All of the compounds display interesting photoluminescent properties and different maximal emission peaks due to the difference of the substituent groups. The cell viability studies indicate that the compounds have excellent antiproliferative activity against four human carcinoma cell lines, A549, Bel-7402, MCF-7, and Eca-109, with the lowest IC50 values of 0.33 (10), 0.66 (6), 0.37 (7), and 1.05 (7) \u03bcM, respectively. The spectrophotometric results reveal that the compounds have strong affinity binding with DNA as intercalator and induce DNA conformational transition. Molecular docking studies indicate that the binding is contributed by the \u03c0\u2026\u03c0 stacking and hydrogen bonds, providing an order of nucleotide sequence binding selectivity as ATGC &gt; ATAT &gt; GCGC. These compounds intercalate into the base pairs of the DNA of the tumor cells to affect their replication and transcription, and the process is supposed to play an important role in the anticancer mechanism.<\/jats:p>","DOI":"10.3390\/molecules24244519","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T10:52:41Z","timestamp":1575975161000},"page":"4519","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Zinc(II) Terpyridine Complexes: Substituent Effect on Photoluminescence, Antiproliferative Activity, and DNA Interaction"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8308-5382","authenticated-orcid":false,"given":"Jiahe","family":"Li","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"},{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongping","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhang","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Huang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530004, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Pan","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530004, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1629-7764","authenticated-orcid":false,"given":"Zhen","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"},{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/(SICI)1521-3773(19990601)38:11<1512::AID-ANIE1512>3.0.CO;2-Y","article-title":"Metals in medicine","volume":"38","author":"Guo","year":"1999","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1021\/cr980420v","article-title":"Current status of platinum-based antitumor drugs","volume":"99","author":"Wong","year":"1999","journal-title":"Chem. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1021\/cr980421n","article-title":"Structure, recognition, and processing of cisplatin\u2212DNA adducts","volume":"99","author":"Jamieson","year":"1999","journal-title":"Chem. 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