{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:32:44Z","timestamp":1778715164706,"version":"3.51.4"},"reference-count":42,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["EDITAL 04\/PGFAR\/2018"],"award-info":[{"award-number":["EDITAL 04\/PGFAR\/2018"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Banana inflorescences are a byproduct of banana cultivation consumed in various regions of Brazil as a non-conventional food. This byproduct represents an alternative food supply that can contribute to the resolution of nutritional problems and hunger. This product is also used in Asia as a traditional remedy for the treatment of various illnesses such as bronchitis and dysentery. However, there is a lack of chemical and pharmacological data to support its consumption as a functional food. Therefore, this work aimed to study the anti-inflammatory action of Musa acuminata blossom by quantifying the cytokine levels (NOx, IL-1\u03b2, TNF-\u03b1, and IL-6) in peritoneal neutrophils, and to study its antiparasitic activities using the intracellular forms of T. cruzi, L. amazonensis, and L. infantum. This work also aimed to establish the chemical profile of the inflorescence using UPLC-ESI-MS analysis. Flowers and the crude bract extracts were partitioned in dichloromethane and n-butanol to afford four fractions (FDCM, FNBU, BDCM, and BNBU). FDCM showed moderate trypanocidal activity and promising anti-inflammatory properties by inhibiting IL-1\u03b2, TNF-\u03b1, and IL-6. BDCM significantly inhibited the secretion of TNF-\u03b1, while BNBU was active against IL-6 and NOx. LCMS data of these fractions revealed an unprecedented presence of arylpropanoid sucroses alongside flavonoids, triterpenes, benzofurans, stilbenes, and iridoids. The obtained results revealed that banana inflorescences could be used as an anti-inflammatory food ingredient to control inflammatory diseases.<\/jats:p>","DOI":"10.3390\/molecules24244564","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T11:27:22Z","timestamp":1576236442000},"page":"4564","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["NOx-, IL-1\u03b2-, TNF-\u03b1-, and IL-6-Inhibiting Effects and Trypanocidal Activity of Banana (Musa acuminata) Bracts and Flowers: UPLC-HRESI-MS Detection of Phenylpropanoid Sucrose Esters"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-7733","authenticated-orcid":false,"given":"Louis P.","family":"Sandjo","sequence":"first","affiliation":[{"name":"Department of Chemistry, Federal University of Santa Catarina, 88040-900 Florian\u00f3polis, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3000-9116","authenticated-orcid":false,"given":"Marcus V. P.","family":"dos Santos Nascimento","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Centre of Health Sciences, Federal University of Santa Catarina, 88 040 970 Florian\u00f3polis, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milene","family":"de H. Moraes","sequence":"additional","affiliation":[{"name":"Laboratory of Protozoology, Department of Microbiology, Immunology and Parasitology Centre of biological sciences, Federal University of Santa Catarina, 88040-900 Florian\u00f3polis, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Manaut","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Protozoology, Department of Microbiology, Immunology and Parasitology Centre of biological sciences, Federal University of Santa Catarina, 88040-900 Florian\u00f3polis, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo M.","family":"Dalmarco","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Centre of Health Sciences, Federal University of Santa Catarina, 88 040 970 Florian\u00f3polis, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maique W.","family":"Biavatti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Centre of Health Sciences, Federal University of Santa Catarina, 88040-900 Florian\u00f3polis, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Steindel","sequence":"additional","affiliation":[{"name":"Laboratory of Protozoology, Department of Microbiology, Immunology and Parasitology Centre of biological sciences, Federal University of Santa Catarina, 88040-900 Florian\u00f3polis, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"ref_1","unstructured":"Nunes, H. 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