{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:37:20Z","timestamp":1760402240451,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003069","name":"Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["20160855"],"award-info":[{"award-number":["20160855"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The anti-depressive and anxiolytic effect of galphimine B (isolated from Galphimia glauca) has been demonstrated by researchers. Therefore, it is necessary to explore extraction techniques that produce materials with adequate quality for pharmaceutical applications. In this work, supercritical extractions of galphimines from Galphimia glauca were performed in the presence of carbon dioxide. Pressure, temperature, particle diameter, and flow rate effects were examined to explore the conditions with the highest yield and the concentration profile of galphimines in the studied interval. The identification of the nor-seco triterpenoids and galphimine B and E was carried out by HPLC analyses. The mathematical modeling of the extraction curves was attained by the approaches proposed by Sovov\u00e1 and Papamichail et al. According to results, the highest yield 2.22% was obtained at 323.15 K, 326 \u03bcm, 3 L\/min, and 33.75 MPa. Meanwhile, the content of galphimine B in the extract was, on average, 19.5 mg\u00b7g\u22121.<\/jats:p>","DOI":"10.3390\/molecules25030477","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T11:41:57Z","timestamp":1580125317000},"page":"477","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Extraction of Galphimines from Galphimia glauca with Supercritical Carbon Dioxide"],"prefix":"10.3390","volume":"25","author":[{"given":"Francisco Javier","family":"Ver\u00f3nico S\u00e1nchez","sequence":"first","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica Petrolera and Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Ingenier\u00eda Qu\u00edmica e Industrias Extractivas, Instituto Polit\u00e9cnico Nacional (IPN), Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-3554","authenticated-orcid":false,"given":"Octavio","family":"Elizalde Solis","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica Petrolera and Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Ingenier\u00eda Qu\u00edmica e Industrias Extractivas, Instituto Polit\u00e9cnico Nacional (IPN), Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-5958","authenticated-orcid":false,"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Morelos 62790, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Garc\u00eda Morales","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica Petrolera and Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Ingenier\u00eda Qu\u00edmica e Industrias Extractivas, Instituto Polit\u00e9cnico Nacional (IPN), Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5456-0677","authenticated-orcid":false,"given":"Ma. Dolores","family":"P\u00e9rez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Morelos 62790, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-8274","authenticated-orcid":false,"given":"Jes\u00fas E.","family":"Jim\u00e9nez Ferrer","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Morelos 62790, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Tortoriello","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Morelos 62790, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"ref_1","unstructured":"Argueta, A., Cano, L.M., and Rodarte, M.E. 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