{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:54:46Z","timestamp":1784231686690,"version":"3.55.0"},"reference-count":53,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008791","name":"Bayer CropScience","doi-asserted-by":"publisher","award":["Grants4Targets #2016-01-62"],"award-info":[{"award-number":["Grants4Targets #2016-01-62"]}],"id":[{"id":"10.13039\/100008791","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development.<\/jats:p>","DOI":"10.3390\/molecules25051111","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T03:24:20Z","timestamp":1583292260000},"page":"1111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inhibition of Phytosterol Biosynthesis by Azasterols"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-0903","authenticated-orcid":false,"given":"Sylvain","family":"Darnet","sequence":"first","affiliation":[{"name":"CVACBA, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-750, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-7246","authenticated-orcid":false,"given":"Laetitia","family":"B B Martin","sequence":"additional","affiliation":[{"name":"Plant Isoprenoid Biology (PIB) team, Institut de Biologie Mol\u00e9culaire des Plantes du CNRS, Universit\u00e9 de Strasbourg, 67084 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Mercier","sequence":"additional","affiliation":[{"name":"Plant Isoprenoid Biology (PIB) team, Institut de Biologie Mol\u00e9culaire des Plantes du CNRS, Universit\u00e9 de Strasbourg, 67084 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-8629","authenticated-orcid":false,"given":"Franz","family":"Bracher","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Geoffroy","sequence":"additional","affiliation":[{"name":"Institut de Chimie, Universit\u00e9 de Strasbourg, 67008 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4099-4447","authenticated-orcid":false,"given":"Hubert","family":"Schaller","sequence":"additional","affiliation":[{"name":"Plant Isoprenoid Biology (PIB) team, Institut de Biologie Mol\u00e9culaire des Plantes du CNRS, Universit\u00e9 de Strasbourg, 67084 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"ref_1","first-page":"755","article-title":"Sterol and Steroid Biosynthesis and Metabolism in Plants and Microorganisms","volume":"Volume 132","author":"Mander","year":"2010","journal-title":"Comprehensive Natural Products II: Chemistry and Biology, Volumes 1-10"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Darnet, S., and Schaller, H. 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