{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:00:15Z","timestamp":1774533615948,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The effects of deuterium depletion on the human organism have been, except for the antitumor action, seldom investigated by now and the available data are scarce. In oncological patients who also suffered from diabetes and were treated with deuterium-depleted water (DDW), an improvement of glucose metabolism was observed, and rat studies also proved the efficacy of DDW to reduce blood sugar level. In the present work, 30 volunteers with pre- or manifest diabetes were enrolled to a clinical study. The patients received 1.5 L of water with reduced deuterium content (104 ppm instead of 145 ppm, equivalent 12 mmol\/L in human) daily for 90 days. The effects on fasting glucose and insulin level, on peripheral glucose disposal, and other metabolic parameters were investigated. Fasting insulin and glucose decreased, and insulin reaction on glucose load improved, in 15 subjects, while in the other 15 the changes were opposite. Peripheral glucose disposal was improved in 11 of the subjects. In the majority of the subjects, substantial increase of serum high-density lipoprotein (HDL) cholesterol and significant decrease of serum Na+ concentration were also seen\u2014the latter possibly due to activation of a Na+\/H+ antiporter by the decreased intracellular deuterium level. The results support the possible beneficial role of DDW in disorders of glucose metabolism but leave questions open, requiring further studies.<\/jats:p>","DOI":"10.3390\/molecules25061376","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T07:29:07Z","timestamp":1584689347000},"page":"1376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Systemic Subnormal Deuterium Level on Metabolic Syndrome Related and other Blood Parameters in Humans: A Preliminary Study"],"prefix":"10.3390","volume":"25","author":[{"given":"G\u00e1bor","family":"Somlyai","sequence":"first","affiliation":[{"name":"HYD LLC for Cancer Research and Drug Development, 1118 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildik\u00f3","family":"Somlyai","sequence":"additional","affiliation":[{"name":"HYD LLC for Cancer Research and Drug Development, 1118 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-6079","authenticated-orcid":false,"given":"Istv\u00e1n","family":"F\u00f3rizs","sequence":"additional","affiliation":[{"name":"Institute for Geological and Geochemical Research, Research Centre for Astronomy and Earth Sciences, 1112 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Czuppon","sequence":"additional","affiliation":[{"name":"Institute for Geological and Geochemical Research, Research Centre for Astronomy and Earth Sciences, 1112 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Papp","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Semmelweis University, Faculty of Medicine, Institute of Pathophysiology, 1089 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(93)81479-J","article-title":"Naturally occurring deuterium is essential for the normal growth rate of cells","volume":"317","author":"Somlyai","year":"1993","journal-title":"FEBS Lett."},{"key":"ref_2","unstructured":"Heys, J.R., and Mellino, D.G. 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