{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:25:26Z","timestamp":1789608326197,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["706094"],"award-info":[{"award-number":["706094"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, we isolated from the aerial parts of Baccharis conferta Kunth (i) a new neoclerodane, denominated \u201cbacchofertone\u201d; (ii) four known terpenes: schensianol A, bacchofertin, kingidiol and oleanolic acid; and (iii) two flavonoids: cirsimaritin and hispidulin. All structures were identified by an exhaustive analysis of nuclear magnetic resonance (NMR) and mass spectroscopy (MS). Extracts from aerial parts were screened for anti-inflammatory activity in the mice ear edema model of 12-O-tetradecanoylforbol-13-acetate mice. Dichloromethane extract (BcD) exhibited 78.5 \u00b1 0.72% inhibition of edema, followed by the BcD2 and BcD3 fractions of 71.4% and 82.9% respectively, at a dose of 1 mg\/ear. Kingidiol and cirsimaritin were the most potent compounds identified, with a median effective dose of 0.12 and 0.16 mg\/ear, respectively. A histological analysis showed that the topical application of TPA promoted intense cell infiltration, and this inflammatory parameter was reduced with the topical application of isolated compounds.<\/jats:p>","DOI":"10.3390\/molecules25061379","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T07:29:07Z","timestamp":1584689347000},"page":"1379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Terpenoids and Flavonoids Isolated from Baccharis conferta Kunth on TPA-Induced Ear Edema in Mice"],"prefix":"10.3390","volume":"25","author":[{"given":"Guti\u00e9rrez-Rom\u00e1n","family":"Ana Silvia","sequence":"first","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos. Instituto Polit\u00e9cnico Nacional (IPN), Col. San Isidro, Carretera Yautepec-Jojutla, Km 6, 62731, Morelos, Mexico"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Col. Centro, Xochitepec, 62790 Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-9332","authenticated-orcid":false,"given":"Trejo-Tapia","family":"Gabriela","sequence":"additional","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos. Instituto Polit\u00e9cnico Nacional (IPN), Col. San Isidro, Carretera Yautepec-Jojutla, Km 6, 62731, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herrera-Ruiz","family":"Maribel","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Col. Centro, Xochitepec, 62790 Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monterrosas-Brisson","family":"Nayeli","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca, 62209 Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trejo-Espino","family":"Jos\u00e9 Luis","sequence":"additional","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos. Instituto Polit\u00e9cnico Nacional (IPN), Col. San Isidro, Carretera Yautepec-Jojutla, Km 6, 62731, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-5958","authenticated-orcid":false,"given":"Zamilpa","family":"Alejandro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Col. Centro, Xochitepec, 62790 Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Gonz\u00e1lez-Cortazar","family":"Manas\u00e9s","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Col. Centro, Xochitepec, 62790 Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S1572-5995(05)80045-6","article-title":"Biologically active substances from the genus Baccharis L. (Compositae)","volume":"30","author":"Bessa","year":"2005","journal-title":"Stud. Nat. Prod. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbdv.201400363","article-title":"Baccharis (Asteraceae): Chemical constituents and biological activities","volume":"13","author":"Bressan","year":"2016","journal-title":"Chem. Biodiversity"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.phytol.2018.11.008","article-title":"Scutebatolides A-C, new neo-clerodane diterpenoids from Scutellaria barbata D. 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