{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:09:05Z","timestamp":1762272545628,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["20154JRJPP_004"],"award-info":[{"award-number":["20154JRJPP_004"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003852","name":"Regione Campania","doi-asserted-by":"publisher","award":["B61G18000470007"],"award-info":[{"award-number":["B61G18000470007"]}],"id":[{"id":"10.13039\/501100003852","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Malaria is a life-threatening disease and, what is more, the resistance to available antimalarial drugs is a recurring problem. The resistance of Plasmodium falciparum malaria parasites to previous generations of medicines has undermined malaria control efforts and reversed gains in child survival. This paper describes a continuation of our ongoing efforts to investigate the effects against Plasmodium falciparum strains and human microvascular endothelial cells (HMEC-1) of a series of methoxy p-benzyl-substituted thiazinoquinones designed starting from a pointed antimalarial lead candidate. The data obtained from the newly tested compounds expanded the structure\u2013activity relationships (SARs) of the thiazinoquinone scaffold, indicating that antiplasmodial activity is not affected by the inductive effect but rather by the resonance effect of the introduced group at the para position of the benzyl substituent. Indeed, the current survey was based on the evaluation of antiparasitic usefulness as well as the selectivity on mammalian cells of the tested p-benzyl-substituted thiazinoquinones, upgrading the knowledge about the active thiazinoquinone scaffold.<\/jats:p>","DOI":"10.3390\/molecules25071530","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T05:55:16Z","timestamp":1585893316000},"page":"1530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antiplasmodial Activity of p-Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5037-712X","authenticated-orcid":false,"given":"Marcello","family":"Casertano","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"},{"name":"Italian Malaria Network, Centro Interuniversitario di Ricerche Sulla Malaria (CIRM), Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4515-3014","authenticated-orcid":false,"given":"Marialuisa","family":"Menna","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"},{"name":"Italian Malaria Network, Centro Interuniversitario di Ricerche Sulla Malaria (CIRM), Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-4281","authenticated-orcid":false,"given":"Caterina","family":"Fattorusso","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"},{"name":"Italian Malaria Network, Centro Interuniversitario di Ricerche Sulla Malaria (CIRM), Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9030-1066","authenticated-orcid":false,"given":"Nicoletta","family":"Basilico","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universit\u00e0 di Milano, Via Pascal 36, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-8892","authenticated-orcid":false,"given":"Silvia","family":"Parapini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche per la Salute, Universit\u00e0 di Milano, Via Pascal 36, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-0338","authenticated-orcid":false,"given":"Marco","family":"Persico","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"},{"name":"Italian Malaria Network, Centro Interuniversitario di Ricerche Sulla Malaria (CIRM), Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-0653","authenticated-orcid":false,"given":"Concetta","family":"Imperatore","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"},{"name":"Italian Malaria Network, Centro Interuniversitario di Ricerche Sulla Malaria (CIRM), Department of Pharmacy, University of Naples \u201cFederico II\u201d, Via D. Montesano 49, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"ref_1","unstructured":"WHO (2019, December 04). World Malaria Report 2019. 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