{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:14:28Z","timestamp":1791476068046,"version":"4.3.4"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:00:00Z","timestamp":1585353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A2C2003340"],"award-info":[{"award-number":["2019R1A2C2003340"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Commercializations Promotion Agency for R&amp;D Outcomes (COMPA)\/MSIT","award":["2019A000005"],"award-info":[{"award-number":["2019A000005"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Molecules"],"abstract":"<jats:p>The critical roles of keratinocytes and resident mast cells in skin allergy and inflammation have been highlighted in many studies. Cyclic adenosine monophosphate (cAMP), the intracellular second messenger, has also recently emerged as a target molecule in the immune reaction underlying inflammatory skin conditions. Here, we investigated whether undecane, a naturally occurring plant compound, has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes and we further explored the potential involvement of the cAMP as a molecular target for undecane. We confirmed that undecane increased intracellular cAMP levels in mast cells and keratinocytes. In sensitized mast cells, undecane inhibited degranulation and the secretion of histamine and tumor necrosis factor \u03b1 (TNF-\u03b1). In addition, in sensitized keratinocytes, undecane reversed the increased levels of p38 phosphorylation, nuclear factor kappaB (NF-\u03baB) transcriptional activity and target cytokine\/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). These results suggest that undecane may be useful for the prevention or treatment of skin inflammatory disorders, such as atopic dermatitis, and other allergic diseases.<\/jats:p>","DOI":"10.3390\/molecules25071554","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T05:55:16Z","timestamp":1585893316000},"page":"1554","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes"],"prefix":"10.3390","volume":"25","author":[{"given":"Dabin","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesuk","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9752-9407","authenticated-orcid":false,"given":"Taesun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1164\/ajrccm.164.supplement_1.2103024","article-title":"The role of immunoglobulin E in allergy and asthma","volume":"164","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11129","DOI":"10.1073\/pnas.0505073102","article-title":"Mast cell-committed progenitors","volume":"102","author":"Kitamura","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.4049\/jimmunol.170.4.1630","article-title":"Cutting edge: Both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity","volume":"170","author":"Tanzola","year":"2003","journal-title":"J. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80264-2","article-title":"A dominant role for mast cell Fc receptors in the Arthus reaction","volume":"5","author":"Sylvestre","year":"1996","journal-title":"Immunity"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri2327","article-title":"Immunomodulatory mast cells: Negative, as well as positive, regulators of immunity","volume":"8","author":"Galli","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/9781119278368.ch2.1","article-title":"A review of the roles of keratinocyte-derived cytokines and chemokines in the pathogenesis of atopic dermatitis in humans and dogs","volume":"8","author":"Asahina","year":"2017","journal-title":"Vet. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.bi.37.070168.001053","article-title":"Cyclic AMP","volume":"37","author":"Robinson","year":"1968","journal-title":"Annu. Rev. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fimmu.2016.00123","article-title":"The cAMP pathway as therapeutic target in autoimmune and inflammatory diseases","volume":"7","author":"Raker","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1189\/jlb.0212109","article-title":"E-prostanoid 2 receptors dampen mast cell degranulation via cAMP\/PKA-mediated suppression of IgE-dependent signaling","volume":"92","author":"Olivera","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0306-3623(98)00080-9","article-title":"Regulation of human mast cell and basophil function by cAMP","volume":"31","author":"Weston","year":"1998","journal-title":"Gen. Pharmacol. Vasc. S."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Berridge, M. (1982). Regulation of cell secretion: The integrated action of cyclic AMP and calcium. Cyclic Nucleotides, Springer.","DOI":"10.1007\/978-3-642-68393-0_5"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.bcp.2012.01.001","article-title":"Apremilast mechanism of action and application to psoriasis and psoriatic arthritis","volume":"83","author":"Schafer","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jaci.2004.08.041","article-title":"Prostaglandin E2 suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes","volume":"114","author":"Kanda","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.molimm.2009.03.018","article-title":"The adenylyl cyclase-cAMP system suppresses TARC\/CCL17 and MDC\/CCL22 production through p38 MAPK and NF-\u03baB in HaCaT keratinocytes","volume":"46","author":"Qi","year":"2009","journal-title":"Mol. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1365-2133.2003.04934.x","article-title":"Clinical dose and adverse effects of topical steroids in daily management of atopic dermatitis","volume":"148","author":"Furue","year":"2003","journal-title":"Br. J. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000051700","article-title":"Safe and effective treatment of refractory facial lesions in atopic dermatitis using topical tacrolimus following corticosteroid discontinuation","volume":"203","author":"Kawakami","year":"2001","journal-title":"Dermatology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S1567-5769(01)00059-5","article-title":"Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system.(Comparison with steroids)","volume":"1","author":"Sakuma","year":"2001","journal-title":"Int. Immunopharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2165\/00002018-199614060-00003","article-title":"Topical glucocorticoids with improved risk-benefit ratio","volume":"14","author":"Schmid","year":"1996","journal-title":"Drug Saf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1745-4514.2009.00270.x","article-title":"Essential oil composition of Salvia verbenaca L. growing wild in Tunisia","volume":"34","author":"TAARIT","year":"2010","journal-title":"J. Food Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0091-6749(05)80223-4","article-title":"The role of histamine in allergic diseases","volume":"86","author":"White","year":"1990","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1067\/mai.2003.1585","article-title":"Histamine in the immune regulation of allergic inflammation","volume":"112","author":"Akdis","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1749-6632.1995.tb17489.x","article-title":"Molecular and functional diversity of histamine receptor subtypes","volume":"757","author":"Arrang","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1365-2222.1999.00007.x-i1","article-title":"Molecular properties and signalling pathways of the histamine H1 receptor","volume":"29","author":"Smit","year":"1999","journal-title":"Clin. Exp. Allergy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1523-1747.2001.01238.x","article-title":"Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment","volume":"116","author":"Ashida","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s11882-004-0071-8","article-title":"Keratinocytes in atopic dermatitis: Inflammatory signals","volume":"4","author":"Esche","year":"2004","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1067\/mai.2001.114707","article-title":"Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell\u2013derived cytokines","volume":"107","author":"Giustizieri","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.det.2007.06.003","article-title":"Keratinocyte cytokine and chemokine receptors","volume":"25","author":"Antonov","year":"2007","journal-title":"Dermatol. Clin."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.4049\/jimmunol.175.3.1523","article-title":"Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages","volume":"175","author":"Jin","year":"2005","journal-title":"J. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0022-3565(24)34969-9","article-title":"Amplification of the Cyclic AMP Response to Forskolin in Pheochromocytoma PC12 Cells through Adenosine A2APurinoceptors","volume":"290","author":"Florio","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.4049\/jimmunol.160.7.3562","article-title":"Regulation of macrophage phagocytosis of apoptotic cells by cAMP","volume":"160","author":"Rossi","year":"1998","journal-title":"J. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0898-6568(01)00214-5","article-title":"Molecular mechanisms for protein kinase A-mediated modulation of immune function","volume":"14","author":"Torgersen","year":"2002","journal-title":"Cell. Signal."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00021.2003","article-title":"Localized effects of cAMP mediated by distinct routes of protein kinase A","volume":"84","author":"Tasken","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"52095","DOI":"10.1074\/jbc.M405697200","article-title":"Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes an in vivo study using adenovirus-mediated expression of cng channels","volume":"279","author":"Rochais","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1074\/jbc.275.15.10831","article-title":"Short Term Feedback Regulation of cAMP in FRTL-5 Thyroid Cells ROLE OF PDE4D3 PHOSPHODIESTERASE ACTIVATION","volume":"275","author":"Oki","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1365-2222.2003.01608.x","article-title":"Developmental changes in interleukin-12-producing ability by monocytes and their relevance to allergic diseases","volume":"33","author":"Itazawa","year":"2003","journal-title":"Clin. Exp. Allergy"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1365-2230.2005.01709.x","article-title":"The mode of topical immunomodulators in the immunological network of atopic dermatitis","volume":"30","author":"Novak","year":"2005","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jaad.2004.11.022","article-title":"Infliximab in the treatment of moderate to severe atopic dermatitis","volume":"52","author":"Jacobi","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00005-017-0487-1","article-title":"Novel therapeutic approaches to atopic dermatitis","volume":"66","author":"Osinka","year":"2018","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5500\/wjt.v3.i3.30","article-title":"New developments in transplant-acquired allergies","volume":"3","year":"2013","journal-title":"World J. Transplant."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4062\/biomolther.2014.023","article-title":"The leaves of Broussonetia kazinoki siebold inhibit atopic dermatitis-like response on mite allergen-treated Nc\/Nga mice","volume":"22","author":"Lee","year":"2014","journal-title":"Biomol. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/21553769.2014.901924","article-title":"Designing of multi-target-directed ligands against the enzymes associated with neuroinflammation: An in silico approach","volume":"7","author":"Dileep","year":"2013","journal-title":"Front. Life Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00011-015-0851-8","article-title":"Multi-target drugs to address multiple checkpoints in complex inflammatory pathologies: Evolutionary cues for novel \u201cfirst-in-class\u201d anti-inflammatory drug candidates: A reviewer\u2019s perspective","volume":"64","author":"Mathew","year":"2015","journal-title":"Inflamm. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jaci.2006.03.046","article-title":"Immunopathology of atopic dermatitis","volume":"118","author":"Fiset","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3389\/fphar.2018.01048","article-title":"Phosphodiesterase-4 inhibitors for the treatment of inflammatory diseases","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1074\/jbc.275.12.8263","article-title":"Stimulus-specific interaction between activator-coactivator cognates revealed with a novel complex-specific antiserum","volume":"275","author":"Wagner","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"10936","DOI":"10.1073\/pnas.191152098","article-title":"Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB","volume":"98","author":"Mayr","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"}],"updated-by":[{"DOI":"10.3390\/molecules30081768","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:00:00Z","timestamp":1585353600000}}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/7\/1554\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:18:54Z","timestamp":1754259534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/7\/1554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,28]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["molecules25071554"],"URL":"https:\/\/doi.org\/10.3390\/molecules25071554","relation":{"correction":[{"id-type":"doi","id":"10.3390\/molecules30081768","asserted-by":"object"}]},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,28]]}}}