{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T16:08:00Z","timestamp":1771690080497,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"South African National Research Foundation","award":["107270"],"award-info":[{"award-number":["107270"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields. The resultant compounds were evaluated in vitro for their potential activity against a cultured Trypanosoma brucei brucei 427 strain. Several compounds displayed mostly modest in vitro anti-trypanosomal activity with compounds 10e and 10h emerging as active candidates with IC50 values of 4.09 and 5.11 \u00b5M, respectively. More importantly, a concomitant assessment of their activity against a human cervix adenocarcinoma (HeLa) cell line revealed that these compounds are non-toxic.<\/jats:p>","DOI":"10.3390\/molecules25071668","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T05:31:16Z","timestamp":1586496676000},"page":"1668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-5588","authenticated-orcid":false,"given":"Ayanda I.","family":"Zulu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-5502","authenticated-orcid":false,"given":"Ogunyemi O.","family":"Oderinlo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuan","family":"Kruger","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Centre for Chemico and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-1955","authenticated-orcid":false,"given":"Heinrich C.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Centre for Chemico and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa"},{"name":"Department of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3546-3884","authenticated-orcid":false,"given":"Vincent J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa"},{"name":"Centre for Chemico and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4043-7106","authenticated-orcid":false,"given":"Clinton G. L.","family":"Veale","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics, Pietermaritzburg Campus, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, South Africa"},{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-5738","authenticated-orcid":false,"given":"Setshaba D.","family":"Khanye","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa"},{"name":"Centre for Chemico and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa"},{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s40267-019-00672-2","article-title":"Fexinidazole in human African trypanosomiasis: A profile of its use","volume":"35","author":"Deeks","year":"2019","journal-title":"Drugs Ther. 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