{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:17:07Z","timestamp":1785867427272,"version":"3.56.0"},"reference-count":214,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/03489-1"],"award-info":[{"award-number":["2017\/03489-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/15982-6"],"award-info":[{"award-number":["2014\/15982-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2008\/57906-3"],"award-info":[{"award-number":["2008\/57906-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/14818-9"],"award-info":[{"award-number":["2018\/14818-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["20131776"],"award-info":[{"award-number":["20131776"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["573913\/2008-0"],"award-info":[{"award-number":["573913\/2008-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been linked to important human diseases, although some kinase families remain neglected in terms of research, hiding their relevance to therapeutic approaches. Here, a review regarding the NEK family is presented, shedding light on important information related to NEKs and human diseases. NEKs are a large group of homologous kinases with related functions and structures that participate in several cellular processes such as the cell cycle, cell division, cilia formation, and the DNA damage response. The review of the literature points to the pivotal participation of NEKs in important human diseases, like different types of cancer, diabetes, ciliopathies and central nervous system related and inflammatory-related diseases. The different known regulatory molecular mechanisms specific to each NEK are also presented, relating to their involvement in different diseases. In addition, important information about NEKs remains to be elucidated and is highlighted in this review, showing the need for other studies and research regarding this kinase family. Therefore, the NEK family represents an important group of kinases with potential applications in the therapy of human diseases.<\/jats:p>","DOI":"10.3390\/molecules25081778","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T03:10:01Z","timestamp":1586833801000},"page":"1778","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Checking NEKs: Overcoming a Bottleneck in Human Diseases"],"prefix":"10.3390","volume":"25","author":[{"given":"Andressa","family":"Peres de Oliveira","sequence":"first","affiliation":[{"name":"Instituto de Biologia, Departamento de Bioqu\u00edmica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-862, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luidy","family":"Kazuo Issayama","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Departamento de Bioqu\u00edmica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-862, Brazil"},{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-871, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora Carolina","family":"Betim Pavan","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Departamento de Bioqu\u00edmica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-862, Brazil"},{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-871, Brazil"},{"name":"Laborat\u00f3rio Multidisciplinar em Alimentos e Sa\u00fade, Faculdade de Ci\u00eancias Aplicadas, Universidade Estadual de Campinas, S\u00e3o Paulo 13484-350, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Riback Silva","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Departamento de Bioqu\u00edmica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-862, Brazil"},{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-871, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita","family":"Diniz Melo-Hanchuk","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Departamento de Bioqu\u00edmica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-862, Brazil"},{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-871, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-9686","authenticated-orcid":false,"given":"Fernando","family":"Moreira Simabuco","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Multidisciplinar em Alimentos e Sa\u00fade, Faculdade de Ci\u00eancias Aplicadas, Universidade Estadual de Campinas, S\u00e3o Paulo 13484-350, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-0145","authenticated-orcid":false,"given":"J\u00f6rg","family":"Kobarg","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo 13083-871, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1083\/jcb.96.4.1155","article-title":"A mutation in Aspergillus nidulans that blocks the transition from interphase to prophase","volume":"96","author":"Oakley","year":"1983","journal-title":"J. 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