{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:23:57Z","timestamp":1777955037690,"version":"3.51.4"},"reference-count":53,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1127 ChemBioSys"],"award-info":[{"award-number":["SFB1127 ChemBioSys"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Foundation Sri Lanka","award":["RG\/BS\/2015\/01"],"award-info":[{"award-number":["RG\/BS\/2015\/01"]}]},{"DOI":"10.13039\/100007569","name":"Carl-Zeiss-Stiftung","doi-asserted-by":"publisher","award":["Post-Doc Stipend"],"award-info":[{"award-number":["Post-Doc Stipend"]}],"id":[{"id":"10.13039\/100007569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Traditional folk medicine in Sri Lanka is mostly based on plants and plant-derived products, however, many of these medicinal plant species are scientifically unexplored. Here, we evaluated the anti-inflammatory and antimicrobial potency of 28 different extracts prepared from seven popular medicinal plant species employed in Sri Lanka. The extracts were subjected to cell-based and cell-free assays of 5-lipoxygenase (5-LO), microsomal prostaglandin E2 synthase (mPGES)-1, and nitric oxide (NO) scavenging activity. Moreover, antibacterial and disinfectant activities were assessed. Characterization of secondary metabolites was achieved by gas chromatography coupled to mass spectrometric (GC-MS) analysis. n-Hexane- and dichloromethane-based extracts of Garcinia cambogia efficiently suppressed 5-LO activity in human neutrophils (IC50 = 0.92 and 1.39 \u00b5g\/mL), and potently inhibited isolated human 5-LO (IC50 = 0.15 and 0.16 \u00b5g\/mL) and mPGES-1 (IC50 = 0.29 and 0.49 \u00b5g\/mL). Lipophilic extracts of Pothos scandens displayed potent inhibition of mPGES-1 only. A methanolic extract of Ophiorrhiza mungos caused significant NO scavenging activity. The lipophilic extracts of G. cambogia exhibited prominent antibacterial and disinfectant activities, and GC-MS analysis revealed the presence of fatty acids, sesquiterpenes and other types of secondary metabolites. Together, our results suggest the prospective utilization of G. cambogia as disinfective agent with potent anti-inflammatory properties.<\/jats:p>","DOI":"10.3390\/molecules25081894","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T05:48:52Z","timestamp":1587448132000},"page":"1894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka"],"prefix":"10.3390","volume":"25","author":[{"given":"Mayuri","family":"Napagoda","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle 80000, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Gerstmeier","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Butschek","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhara","family":"De Soyza","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle 80000, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Pace","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sybille","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Research Group Mass Spectrometry and Proteomics, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-3435","authenticated-orcid":false,"given":"Mallique","family":"Qader","sequence":"additional","affiliation":[{"name":"National Institute of Fundamental Studies, Kandy 20000, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeeva","family":"Witharana","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Higher Colleges of Technology, PO Box 4793 Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajith","family":"Nagahawatte","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle 80000, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8330-3597","authenticated-orcid":false,"given":"Gaya","family":"Wijayaratne","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle 80000, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale\u0161","family":"Svato\u0161","sequence":"additional","affiliation":[{"name":"Research Group Mass Spectrometry and Proteomics, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalith","family":"Jayasinghe","sequence":"additional","affiliation":[{"name":"National Institute of Fundamental Studies, Kandy 20000, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-5088","authenticated-orcid":false,"given":"Andreas","family":"Koeberle","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-4379","authenticated-orcid":false,"given":"Oliver","family":"Werz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"ref_1","first-page":"184","article-title":"Inventory, documentation and medicinal plant research in Sri Lanka","volume":"Volume 1","author":"Batugal","year":"2004","journal-title":"Medicinal Plant Research in Asia Volume 1: The Framework and Project Work Plans"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9737302","DOI":"10.1155\/2019\/9737302","article-title":"Traditional uses of medicinal plants in Polonnaruwa district in North Central Province of Sri Lanka","volume":"2019","author":"Napagoda","year":"2019","journal-title":"Scientifica"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9395052","DOI":"10.1155\/2018\/9395052","article-title":"An ethnobotanical study of the medicinal plants used as anti-inflammatory remedies in Gampaha District-Western Province, Sri Lanka","volume":"2018","author":"Napagoda","year":"2018","journal-title":"Scientifica"},{"key":"ref_4","unstructured":"Jayaweera, D.M.A. (1980). Medicinal Plants (Indigenous and Exotic) Used in Ceylon, Part 1\u20135."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1076\/phbi.40.6.433.8441","article-title":"Anti-inflammatory activity of decoctions of leaves and stems of Anisomeles indica at preflowering and flowering stages","volume":"40","author":"Dharmasiri","year":"2002","journal-title":"Pharm. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-8741(03)00159-4","article-title":"Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo","volume":"87","author":"Dharmasiri","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"ref_7","unstructured":"Hapuarachchi, S.D., Suresh, T.S., Senarath, W.T.P.S.K., and Hadunnetthi, S. (2012, January 20). Anti-inflammatory activity of the decoction of M. pinnata. Proceedings of the National Ayurvedic Research Conference, Colombo, Sri Lanka."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.biotechadv.2018.02.010","article-title":"Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis","volume":"36","author":"Koeberle","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.drudis.2014.08.006","article-title":"Multi-target approach for natural products in inflammation","volume":"19","author":"Koeberle","year":"2014","journal-title":"Drug Discov. Today"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jep.2018.04.042","article-title":"Lipophilic extract of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibits key enzymes involved in inflammation and gout","volume":"224","author":"Napagoda","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jep.2013.11.004","article-title":"Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach","volume":"151","author":"Napagoda","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jep.2013.11.052","article-title":"Munronia pinnata (Wall.) Theob. Unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1","volume":"151","author":"Napagoda","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_13","first-page":"469","article-title":"Nitric oxide and superoxide in inflammation and immune regulation","volume":"54","author":"Guzik","year":"2003","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Winyard, P.G., Blake, D.R., and Evans, C.H. (2000). Nitric oxide and inflammatory joint diseases. Free Radicals and Inflammation, Birkh\u00e4user.","DOI":"10.1007\/978-3-0348-8482-2"},{"key":"ref_15","first-page":"583","article-title":"Antioxidant and antimicrobial activities of crude extracts from mangosteen (Garcinia mangostana L.) parts and some essential oils","volume":"17","author":"Palakawong","year":"2010","journal-title":"Int. Food Res. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.sajb.2019.05.021","article-title":"Antimicrobial and antioxidant activity of Garcinia brasiliensis extracts","volume":"124","author":"Naves","year":"2019","journal-title":"S. Afr. J. Bot."},{"key":"ref_17","first-page":"800","article-title":"Antimicrobial, antifungal and antioxidant activity of ethanolic extracts of Garcinia indica fruit","volume":"3","author":"Nagendra","year":"2014","journal-title":"Int. J. Curr. Microbiol. Appl. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1056\/NEJM199012203232505","article-title":"The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air","volume":"323","author":"Israel","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1055\/s-2007-990242","article-title":"Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin","volume":"73","author":"Werz","year":"2007","journal-title":"Planta Med."},{"key":"ref_20","first-page":"147","article-title":"Inducible nitric oxide synthase in human diseases","volume":"113","author":"Fehsel","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-079X.1997.tb00342.x","article-title":"Protective effect of melatonin in carrageenan-induced models of local inflammation","volume":"23","author":"Cuzzocrea","year":"1997","journal-title":"J. Pineal Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"918018","DOI":"10.1155\/2014\/918018","article-title":"Evaluation of nitrite radical scavenging properties of selected Zimbabwean plant extracts and their phytoconstituents","volume":"2014","author":"Boora","year":"2014","journal-title":"J. Food Process."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zoccolotti, J.O., Tasso, C.O., Arbel\u00e1ez, M.I.A., Malavolta, I.F., Pereira, E.C.D.S., Esteves, C.S.G., and Jorge, J.H. (2018). Properties of an acrylic resin after immersion in antiseptic soaps: Low-cost, easy-access procedure for the prevention of denture stomatitis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0203187"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.bcp.2009.02.005","article-title":"Identification of 5- lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol","volume":"77","author":"Koeberle","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1021\/jp201749u","article-title":"Structural photodynamics of camptothecin, an anticancer drug in aqueous solutions","volume":"115","author":"Cohen","year":"2011","journal-title":"J. Phys. Chem. A"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbrc.2010.03.140","article-title":"Advances in eicosanoid research, novel therapeutic implications","volume":"396","author":"Wheelock","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1124\/pr.59.3.1","article-title":"Membrane prostaglandin E synthase-1: A novel therapeutic target","volume":"59","author":"Samuelsson","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.2820055","article-title":"Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects","volume":"237","author":"Samuelsson","year":"1987","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nrd1225","article-title":"COX-2 and beyond: Approaches to prostaglandin inhibition in human disease","volume":"2","author":"FitzGerald","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2015.06.022","article-title":"Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders","volume":"98","author":"Koeberle","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.2174\/092986709789578178","article-title":"Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to nonsteroidal anti-inflammatory drugs (NSAIDs)\u2014A critical review","volume":"16","author":"Koeberle","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/acs.jnatprod.6b01008","article-title":"Evaluation of dual 5-lipoxygenase\/microsomal prostaglandin E2 synthase-1 inhibitory effect of natural and synthetic acronychia-type isoprenylated acetophenones","volume":"80","author":"Svouraki","year":"2017","journal-title":"J. Nat. Prod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ptr.1603","article-title":"Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenasecyclooxygenase","volume":"19","author":"Schneider","year":"2005","journal-title":"Phytother. Res."},{"key":"ref_34","first-page":"4791","article-title":"Anti-inflammatory effects of gambogic acid in murine collagen-induced arthritis through PI3K\/Akt signaling pathway","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.fitote.2015.02.012","article-title":"A comprehensive scientific overview of Garcinia cambogia","volume":"102","author":"Semwal","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Azab, A., Nassar, A., and Azab, A.N. (2016). Anti-Inflammatory activity of natural products. Molecules, 21.","DOI":"10.3390\/molecules21101321"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"FSO35","DOI":"10.4155\/fso.15.35","article-title":"Nitric oxide inhibition strategies","volume":"1","author":"Wong","year":"2015","journal-title":"Future Sci. OA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ptr.1494","article-title":"The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: A preliminary study","volume":"18","author":"Jagetia","year":"2004","journal-title":"Phytother. Res."},{"key":"ref_39","first-page":"31","article-title":"Nitric oxide-scavenging activity of in vitro cultured Balkan medicinal and aromatic plants","volume":"19","author":"Mehandzhiyski","year":"2013","journal-title":"Bulg. J. Agric. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1590\/S1517-83822012000300013","article-title":"Bactericidal antibiotic- phytochemical combinations against methicillin resistant Staphylococcus aureus","volume":"43","author":"Kyaw","year":"2012","journal-title":"Braz. J. Microbiol."},{"key":"ref_41","first-page":"403","article-title":"Antimicrobial activity of flavonoids and steroids isolated from two Chromolaena species","volume":"39","author":"Salvador","year":"2003","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"264","DOI":"10.5395\/rde.2017.42.4.264","article-title":"Evaluation of antimicrobial activity and efficacy of herbal oils and extracts in disinfection of gutta percha cones before obturation","volume":"42","author":"Makade","year":"2017","journal-title":"Restor. Dent. Endod."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e4986","DOI":"10.7717\/peerj.4986","article-title":"Ecotoxicity of disinfectant benzalkonium chloride and its mixture with antineoplastic drug 5-fluorouracil towards alga Pseudokirchneriella subcapitata","volume":"6","author":"Elersek","year":"2018","journal-title":"PeerJ"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"288S","DOI":"10.1177\/1091581810386124","article-title":"Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics","volume":"29","author":"Becker","year":"2010","journal-title":"Int. J. Toxicol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0803601105","article-title":"Beta-caryophyllene is a dietary cannabinoid","volume":"105","author":"Gertsch","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejphar.2007.04.059","article-title":"Anti-inflammatory effects of compounds alpha-humulene and (\u2212)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea","volume":"569","author":"Fernandes","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/288183a0","article-title":"Vitamin E modulates the lipoxygenation of arachidonic acid in leukocytes","volume":"288","author":"Goetzl","year":"1980","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1248\/bpb.19.311","article-title":"Antibacterial activity of some Garcinia benzophenone derivatives against Methicillin-Resistant Staphylococcus aureus","volume":"19","author":"Iinuma","year":"1996","journal-title":"Biol. Pharm. Bull."},{"key":"ref_49","unstructured":"Dassanayake, M.D., and Fosberg, F.R. (1980). A Revised Handbook to the Flora of Ceylon- Complete Set, Taylor & Francis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1096\/fj.02-0815fje","article-title":"Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors","volume":"17","author":"Fischer","year":"2003","journal-title":"FASEB J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8068","DOI":"10.1021\/jm801085s","article-title":"Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase","volume":"51","author":"Koeberle","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1046\/j.1471-4159.2001.00205.x","article-title":"Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals","volume":"76","author":"Asanuma","year":"2001","journal-title":"J. Neurochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4103\/0972-5229.102067","article-title":"Comparative efficacy evaluation of disinfectants routinely used in hospital practice: India","volume":"16","author":"Singh","year":"2012","journal-title":"Indian J. Crit. Care Med."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/8\/1894\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:45:15Z","timestamp":1760363115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/8\/1894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":53,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["molecules25081894"],"URL":"https:\/\/doi.org\/10.3390\/molecules25081894","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,20]]}}}