{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:56:28Z","timestamp":1781700988592,"version":"3.54.5"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The reactions of 2,4-bis(4-methoxyphenyl)-1,3-dithio-2,4-diphosphetane-2,4-disulfide (Lawesson\u2019s Reagent, LR) with benzylamine (BzNH2) and 4-phenylbutylamine (PhBuNH2) yield benzylammonium P-(4-methoxyphenyl)-N-benzyl-amidodithiophosphonate (BzNH3)(BzNH-adtp) and 4-phenylbutylammonium P-(4-methoxyphenyl)-N-(4-phenylbutyl)-amidodithiophosphonate (PhBuNH3)(PhBuNH-adtp). The relevant nickel complexes [Ni(BzNH-adtp)2] and [Ni(PhBuNH-adtp)2] and the corresponding hydrolysed derivatives (BzNH3)2[Ni(dtp)2] and (PhBuNH3)2[Ni(dtp)2] were prepared and fully characterized. The antimicrobial activity of the aforementioned amidodithiophosphonates against a set of Gram-positive and Gram-negative pathogen bacteria was evaluated, and [Ni(BzNH-adtp)2] and [Ni(PhBuNH-adtp)2] showed antiproliferative activity towards Staphylococcus aureus and Staphylococcus haemolyticus strains. density functional theory (DFT) calculations were performed to shed some light on the activity of reported compounds related to their tendency towards P\u2013N bond cleavage.<\/jats:p>","DOI":"10.3390\/molecules25092052","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T01:24:18Z","timestamp":1588123458000},"page":"2052","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Antibacterial Activity of Amidodithiophosphonato Nickel(II) Complexes: An Experimental and Theoretical Approach"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-7751","authenticated-orcid":false,"given":"Enrico","family":"Podda","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato\u2013Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Arca","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato\u2013Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Atzeni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato\u2013Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Coles","sequence":"additional","affiliation":[{"name":"UK National Crystallography Service, School of Chemistry, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Ibba","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Isaia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato\u2013Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Lippolis","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato\u2013Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-4431","authenticated-orcid":false,"given":"Germano","family":"Orr\u00f9","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, Italy"},{"name":"National Research Council of Italy, ISPA-CNR, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Orton","sequence":"additional","affiliation":[{"name":"UK National Crystallography Service, School of Chemistry, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pintus","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato\u2013Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-6307","authenticated-orcid":false,"given":"Enrica","family":"Tuveri","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5010-7370","authenticated-orcid":false,"given":"M. Carla","family":"Aragoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria, SS. 554 bivio Sestu, 09042 Monserrato\u2013Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.ccr.2012.10.010","article-title":"The coordination chemistry of dithiophosphonates: An emerging and versatile ligand class","volume":"257","author":"Woollins","year":"2013","journal-title":"Coord. Chem. Rev."},{"key":"ref_2","unstructured":"McCleverty, J.A., Meyer, J.H., and Thomas, J. (2003). Comprehensive Coordination Chemistry II, Elsevier."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/1099-0682(200010)2000:10<2239::AID-EJIC2239>3.0.CO;2-0","article-title":"Ring-Opening of Lawesson\u2019s Reagent: New Syntheses of Phosphono- and Amidophosphono-Dithioato Complexes \u2212 Structural and CP-MAS 31P-NMR Characterization of [p-CH3OPh(X)PS2]2M (X = MeO, iPrNH.; M = NiII, PdII, and PtII)","volume":"10","author":"Aragoni","year":"2000","journal-title":"Eur. J. Inorg. Chem"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/zaac.200500356","article-title":"Differing Coordination Modes of (O-Alkyl)-p-Ethoxyphenyldithiophosphonato Ligands in Copper(I), Silver(I) and Gold(I) Triphenylphosphine Complexes","volume":"632","author":"Haiduc","year":"2006","journal-title":"Z. Anorg. Allg. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1016\/0277-5387(95)00108-5","article-title":"Stereochemical aspects of phosphor-1,1-dithiolato metal complexes (dithiophosphates, dithiophosphinates): Coordination patterns, molecular structures and supramolecular associations\u2014I","volume":"14","author":"Haiduc","year":"1995","journal-title":"Polyhedron"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0020-1693(97)05491-1","article-title":"New perspectives in phosphonodithioate coordination chemistry. Synthesis and X-ray crystal structure of trans-bis-[O-ethyl-(4-methoxyphenyl)phosphonodithioato] nickel(II)","volume":"262","author":"Arca","year":"1997","journal-title":"Inorg. Chim. Acta"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1039\/b200414c","article-title":"An unprecedented example of a cis-phosphonodithioato nickel(ii) complex built by an extensive hydrogen bonding supramolecular network","volume":"11","author":"Albano","year":"2002","journal-title":"Chem. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1080\/10426507.2017.1358717","article-title":"Solvent-free mechanochemical synthesis of dithiophosphonic acids and corresponding nickel(II) complexes","volume":"192","author":"Ajayi","year":"2017","journal-title":"Phosphorus Sulfur Silicon Relat. Elem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.poly.2006.09.077","article-title":"The synthesis of a new dithiophosphonic acid and its coordination properties toward Ni(II): A combined NMR and X-ray diffraction study","volume":"26","author":"Alberti","year":"2007","journal-title":"Polyhedron"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1016\/j.jorganchem.2006.11.009","article-title":"Transformations of P-chalcogenide precursors with a hydrated metal salt","volume":"692","author":"Shi","year":"2007","journal-title":"J. Organomet. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1039\/C5MD00170F","article-title":"Investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137","volume":"6","author":"Alexander","year":"2015","journal-title":"Med. Chem. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12383","DOI":"10.1021\/jacs.8b08695","article-title":"Characterization and Biological Activity of a Hydrogen Sulfide-Releasing Red Light-Activated Ruthenium(II) Complex","volume":"140","author":"Woods","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.nmni.2015.02.007","article-title":"The global threat of antimicrobial resistance: Science for intervention","volume":"6","author":"Roca","year":"2015","journal-title":"New Microbes New Infect."},{"key":"ref_14","unstructured":"World Health Organization (2019, September 25). Global Action Plan for Antimicrobial Resistance. Available online: https:\/\/www.who.int\/antimicrobial-resistance\/publications\/global-action-plan\/en\/."},{"key":"ref_15","first-page":"277","article-title":"The antibiotic resistance crisis: Part 1: Causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrmicro3028","article-title":"Antimicrobial activity of metals: Mechanisms, molecular targets and applications","volume":"11","author":"Lemire","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1039\/C4DT00022F","article-title":"Gold complexes as antimicrobial agents: An overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure","volume":"43","author":"Djuran","year":"2014","journal-title":"Dalton Trans."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jinorgbio.2017.02.015","article-title":"[Au(pyb-H)(mnt)]: A novel gold(III) 1,2-dithiolene cyclometalated complex with antimicrobial activity (pyb-H=C-deprotonated 2-benzylpyridine; mnt=1,2-dicyanoethene-1,2-dithiolate)","volume":"170","author":"Pintus","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1039\/C5MD00228A","article-title":"Transition metal diamine complexes with antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA)","volume":"6","author":"Karpin","year":"2015","journal-title":"Med. Chem. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-26483-5","article-title":"Antimicrobial and anti-biofilm activity of hexadentated macrocyclic complex of copper (II) derived from thiosemicarbazide against Staphylococcus aureus","volume":"8","author":"Brahma","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: Epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1179\/2047773215Y.0000000030","article-title":"Antimicrobial resistance: A global multifaceted phenomenon","volume":"109","author":"Prestinaci","year":"2015","journal-title":"Pathog. Glob. Health."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1128\/AAC.02008-12","article-title":"Staphylococcus aureus Biofilms Promote Horizontal Transfer of Antibiotic Resistance","volume":"57","author":"Savage","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2217\/fmb.14.64","article-title":"Biofilms in periprosthetic orthopedic infections","volume":"9","author":"McConoughey","year":"2014","journal-title":"Future Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1016\/j.biomaterials.2012.05.031","article-title":"Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials","volume":"33","author":"Arciola","year":"2012","journal-title":"Biomaterials"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1574-695X.2010.00714.x","article-title":"Biofilms in chronic infections-a matter of opportunity-monospecies biofilms in multispecies infections","volume":"59","author":"Thomsen","year":"2010","journal-title":"FEMS. Immunol. Med. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1128\/AAC.03138-14","article-title":"In Vivo Monitoring of Staphylococcus aureus Biofilm Infections and Antimicrobial Therapy by [18F]Fluoro-Deoxyglucose\u2013MicroPET in a Mouse Model","volume":"58","author":"Garrido","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s10096-015-2323-z","article-title":"Biofilm-specific antibiotic tolerance and resistance","volume":"34","author":"Olsen","year":"2015","journal-title":"Eur. J. Clin. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jorganchem.2017.05.028","article-title":"Synthesis and anti-proliferative activities of ruthenium complexes containing the hydrogen sulfide-releasing ligand GYY4137","volume":"843","author":"Leverrier","year":"2017","journal-title":"J. Organomet. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1139\/v01-163","article-title":"An experimental and theoretical approach to phosphonodithioato complexes: Molecular orbital analysis by hybrid-DFT and EHT calculations on trans-bis[O-alkyl-phenylphosphonodithioato]NiII, and vibrational assignments","volume":"79","author":"Aragoni","year":"2001","journal-title":"Can. J. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.poly.2016.09.002","article-title":"Synthesis and structural characterization of Pd(II) and Cu(I) complexes containing dithiophosphorus ligand and their catalytic activities for Heck reaction","volume":"119","author":"Gholivand","year":"2016","journal-title":"Polyhedron"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"13131317","DOI":"10.1080\/10426507.2016.1192622","article-title":"Synthesis, characterization, crystal structure, and antibacterial evaluation of Ni (II) complex with new dithiophosphorus compound","volume":"191","author":"Saadat","year":"2016","journal-title":"Phosphorus Sulfur Silicon Relat. Elem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1107\/S0567740878010912","article-title":"The ethylammonium salt of the nickel(II) complex of ethylidithiophosphonic acid","volume":"34","author":"Arora","year":"1978","journal-title":"Acta Cryst."},{"key":"ref_34","first-page":"m343","article-title":"Aqua carbonyl(ferrocenyldithiophosphonato-2S,S\u2032)bis (tri\u00acphenylphosphane-P)ruthenium(II) dichloromethane monosolvate","volume":"69","author":"Zhu","year":"2013","journal-title":"Acta Cryst."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1021\/om100209k","article-title":"Ruthenium Complexes with Dithiophosphonates [Ar(RO)PS2]\u2212 and [Fc(RO)PS2]\u2212 (Ar = p-CH3OC6H4, Fc = Fe(\u03b75-C5H4)(\u03b75-C5H5))","volume":"29","author":"Wang","year":"2010","journal-title":"Organometallics"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0022-328X(01)01084-1","article-title":"Synthesis and structure of [(C5H5)Fe(C5H4PS2OCH2C6H4N3)]\u2212, a new phosphonodithioate derivative, and its coordination chemistry with rhodium(I) and nickel(II)","volume":"633","author":"Thomas","year":"2001","journal-title":"J. Organomet. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.poly.2012.07.024","article-title":"Photoluminescent Mo(IV) and W(IV) bis-dithiolene complexes with bidentate phosphonodithioato ligand derived from Lawesson\u2019s reagent","volume":"52","author":"Moula","year":"2013","journal-title":"Polyhedron"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s12039-014-0675-z","article-title":"Ni(II) complexes of dithiophosphonic acids","volume":"126","author":"Saadat","year":"2014","journal-title":"J. Chem. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ica.2011.08.044","article-title":"Dinuclear ruthenium complexes containing tripodal dithiophosphonate ligands","volume":"378","author":"Ma","year":"2011","journal-title":"Inorg. Chim. Acta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ica.2004.07.019","article-title":"An unusual cis-phosphonodithioato Pd(II) complex in an extensive hydrogen bonding 3D network","volume":"358","author":"Aragoni","year":"2005","journal-title":"Inorg. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/(SICI)1099-0682(199912)1999:12<2327::AID-EJIC2327>3.0.CO;2-B","article-title":"Novel Condensed Thionated Bis(phosphonic) Acid Salts with a Rigid Naphthalene-1,8-diyl Backbone","volume":"12","author":"Kilian","year":"1999","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_42","first-page":"11","article-title":"Antimicrobial susceptibility pattern to disinfectants in Pseudomonas aeruginosa strains isolated from dairy sheep breeds in Sardinia","volume":"25","author":"Scano","year":"2019","journal-title":"Large Anim. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"46S","DOI":"10.1046\/j.1365-2672.92.5s1.7.x","article-title":"Cellular impermeability and uptake of biocides and antibiotics in Gram-positive bacteria and mycobacteria","volume":"92","author":"Lambert","year":"2002","journal-title":"J. Appl. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.1046\/j.1365-2672.92.5s1.19.x","article-title":"Cellular impermeability and uptake of biocides and antibiotics in Gram-negative bacteria","volume":"92","author":"Denyer","year":"2002","journal-title":"J. Appl. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/mmy.39.1.1.8-0","article-title":"Molecular organization of the cell wall of Candida albicans","volume":"39","author":"Klis","year":"2001","journal-title":"Med. Mycol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1039\/b503883a","article-title":"DFT calculations, structural and spectroscopic studies on the products formed between IBr and N,N\u2032-dimethylbenzoimidazole-2(3H)-thione and -2(3H)-selone","volume":"13","author":"Aragoni","year":"2005","journal-title":"Dalton Trans."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"9610","DOI":"10.1021\/ic051260q","article-title":"[M(R-dmet)2] Bis(1,2-dithiolenes):\u2009 a Promising New Class Intermediate between [M(dmit)2] and [M(R,R\u2018-timdt)2] (M = Ni, Pd, Pt)","volume":"26","author":"Aragoni","year":"2005","journal-title":"Inorg. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/asia.201000525","article-title":"Gold(III) Complexes of Asymmetrically Aryl-Substituted 1,2-Dithiolene Ligands Featuring Potential-Controlled Spectroscopic Properties: An Insight into the Electronic Properties of bis(Pyren-1-yl-ethylene-1,2-dithiolato)Gold(III)","volume":"6","author":"Aragoni","year":"2011","journal-title":"Chem. Asian J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"11821","DOI":"10.1039\/C9NJ01593K","article-title":"Reaction of imidazoline-2-selone derivatives with mesityltellurenyl iodide: A unique example of a 3c-4e Se\u2192Te\u2190Se three-body system embedding a tellurenyl cation","volume":"43","author":"Aragoni","year":"2019","journal-title":"New J. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Koch, W., and Holthausen, M.C.A. (2002). Chemist\u2019s Guide to Density Functional Theory, Wiley-VCH. [2nd ed.].","DOI":"10.1002\/3527600043"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a Novel, Water-Soluble Hydrogen Sulfide\u2013Releasing Molecule (GYY4137)","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"ref_52","unstructured":"(2018). Rigaku Oxford Diffraction, CrysAlisPro Software System, Rigaku Corporation. Version 1.171.39.46."},{"key":"ref_53","first-page":"3","article-title":"SHELXT-Integrated space-group and crystal-structure determination","volume":"A71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","article-title":"OLEX2: A complete structure solution, refinement and analysis program","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Cryst."},{"key":"ref_55","first-page":"3","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1063\/1.475428","article-title":"Exchange functionals with improved long-range behavior and adiabatic connection methods without adjustable parameters: The mPW and mPW1PW models","volume":"108","author":"Adamo","year":"1998","journal-title":"J. Chem. Phys."},{"key":"ref_57","unstructured":"Frisch, M.J., Trucks, G.W., Schlegel, H.B., Scuseria, G.E., Robb, M.A., Cheeseman, J.R., Scalmani, G., Barone, V., Petersson, G.A., and Nakatsuji, H. (2016). Gaussian 16, Gaussian, Inc.. Revision C.01."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1039\/b508541a","article-title":"Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy","volume":"7","author":"Weigend","year":"2005","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1063\/1.449486","article-title":"Natural population analysis","volume":"83","author":"Reed","year":"1985","journal-title":"J. Chem. Phys."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0040-4020(68)88057-3","article-title":"Application of the pople-santry-segal CNDO method to the cyclopropylcarbinyl and cyclobutyl cation and to bicyclobutane","volume":"24","author":"Wiberg","year":"1968","journal-title":"Tetrahedron"},{"key":"ref_61","unstructured":"Skripnikov, L.V. (2017). Chemissian, Visualization Computer Program, St.. Version 4.53."},{"key":"ref_62","unstructured":"Dennington, R., Keith, T., and Millam, J. (2009). GaussView, Semichem Inc.. Version 6.0."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1008193805436","article-title":"Molden: A pre- and post-processing program for molecular and electronic structures","volume":"14","author":"Schaftenaar","year":"2000","journal-title":"J. Comput. Aided Mol. Des."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1128\/JCM.43.6.2629-2634.2005","article-title":"Nationwide Antibiogram Analysis Using NCCLS M39-A Guidelines","volume":"43","author":"Zapantis","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2174\/1874210601004010140","article-title":"Evaluation of Antimicrobial-Antibiofilm Activity of a Hydrogen Peroxide Decontaminating System Used in Dental Unit Water Lines","volume":"4","author":"Orru","year":"2010","journal-title":"Open Dent. J."},{"key":"ref_66","first-page":"135","article-title":"Antimicrobial Susceptibility Testing by the Kirby-Bauer Disc Diffusion Method","volume":"3","author":"Biemer","year":"1973","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jep.2004.06.013","article-title":"Use of a modified microplate bioassay method to investigate antibacterial activity in the Peruvian medicinal plant Peperomia galioides","volume":"94","author":"Langfield","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand","year":"2008","journal-title":"Nat. Protoc."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Merritt, J.H., Kadouri, D.E., and O\u2019Toole, G.A. (2005). Growing and analyzing static biofilms. Curr. Protoc. Microbiol.","DOI":"10.1002\/9780471729259.mc01b01s00"},{"key":"ref_70","first-page":"7822","article-title":"Dithiophosphorus-Palladium Complexes as a Catalyst in the Heck Reaction via Pd(II)\/Pd(IV) Catalytic Cycle: A Combined Experimental and Computational Study","volume":"3","author":"Gholivand","year":"2018","journal-title":"Chem. Sel."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/9\/2052\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:32:11Z","timestamp":1760362331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/9\/2052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,28]]},"references-count":70,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,5]]}},"alternative-id":["molecules25092052"],"URL":"https:\/\/doi.org\/10.3390\/molecules25092052","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,28]]}}}