{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:25:12Z","timestamp":1783002312022,"version":"3.54.5"},"reference-count":441,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["FNK"],"award-info":[{"award-number":["FNK"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Acquired Immunodeficiency Syndrome (AIDS), which chiefly originatesfroma retrovirus named Human Immunodeficiency Virus (HIV), has impacted about 70 million people worldwide. Even though several advances have been made in the field of antiretroviral combination therapy, HIV is still responsible for a considerable number of deaths in Africa. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. Presently, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate drugs derived from plants as well as their derivatives. Several plants, such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity. Here, weattempt to summarize the main results, which focus on the structures of most potent plant-based natural products having anti-HIV activity along with their mechanisms of action and IC50 values, structure-activity-relationships and important key findings.<\/jats:p>","DOI":"10.3390\/molecules25092070","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T13:23:45Z","timestamp":1588166625000},"page":"2070","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products"],"prefix":"10.3390","volume":"25","author":[{"given":"Ramandeep","family":"Kaur","sequence":"first","affiliation":[{"name":"Sri Sai College of Pharmacy, Manawala, Amritsar 143001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Sharma","sequence":"additional","affiliation":[{"name":"Sri Sai College of Pharmacy, Manawala, Amritsar 143001, India"},{"name":"Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6981-4024","authenticated-orcid":false,"given":"Girish K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Sri Sai College of Pharmacy, Badhani, Pathankot 145001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-394X","authenticated-orcid":false,"given":"Fidele","family":"Ntie-Kang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Buea, P.O. Box 63 Buea, Cameroon"},{"name":"Institute for Pharmacy, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120 Halle (Saale), Germany"},{"name":"Institut f\u00fcr Botanik, Technische Universit\u00e4t Dresden, Zellescher Weg 20b, 01062 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Sri Sai College of Pharmacy, Manawala, Amritsar 143001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s11418-011-0513-2","article-title":"Anti-HIV activity of Indian medicinal plants","volume":"65","author":"Sabde","year":"2011","journal-title":"J. Nat. 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