{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:29:48Z","timestamp":1772252988371,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003664","name":"Korea Forest Service","doi-asserted-by":"publisher","award":["2017037A00-1919-BA01"],"award-info":[{"award-number":["2017037A00-1919-BA01"]}],"id":[{"id":"10.13039\/501100003664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Quercus mongolica (QM)\u2014a member of the Fagaceae family\u2014has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition of inflammatory cytokines (IL-6 and IL-8) of QM leaf extract (QML) and its main compound, pedunculagin (PD) in vitro and 5\u03b1-reductase inhibitory activity by western blotting. As results, QML and PD showed potent NO production inhibitory activity compared with the positive control (PC), NG-monomethyl-L-arginine (L-NMMA). QML and PD was also showed the decreases of IL-6 and IL-8 compared with the PC, EGCG and exhibited potent 5\u03b1-reductase type 1 inhibitory activities compared with the PC, dutasteride.<\/jats:p>","DOI":"10.3390\/molecules25092154","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T04:46:07Z","timestamp":1588826767000},"page":"2154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of Quercus mongolica by Anti-Inflammatory Activity and 5\u03b1-Reductase Inhibition"],"prefix":"10.3390","volume":"25","author":[{"given":"Min","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156\u2013756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156\u2013756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Hyeok","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156\u2013756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hui","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156\u2013756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Kyeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156\u2013756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156\u2013756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8018-5652","authenticated-orcid":false,"given":"Min Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156\u2013756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1038\/jid.2015.277","article-title":"Nitric Oxide-Releasing Nanoparticles Prevent Propionibacterium acnes-Induced Inflammation by Both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response","volume":"135","author":"Qin","year":"2015","journal-title":"J. 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