{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:48:43Z","timestamp":1779299323279,"version":"3.51.4"},"reference-count":82,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research and Researchers for Industries (RRI) PhD. Program, Thailand Science Research","award":["PHD56I0036"],"award-info":[{"award-number":["PHD56I0036"]}]},{"name":"Faculty of Medicine Endowment Fund, Chiang Mai University through Associate Professor Somdet Srichairatanakool, PhD","award":["015\/2560"],"award-info":[{"award-number":["015\/2560"]}]},{"name":"British Council-Newton Fund (PhD. Placement) through Miss Adchara Prommaban","award":["2016"],"award-info":[{"award-number":["2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Plant seeds have been found to contain bioactive compounds that have potential nutraceutical benefits. Guava seeds (Psidium guajava) are by-products in the beverage and juice industry; however, they can be utilized for a variety of commercial purposes. This study was designed to analyze the phytochemicals of the n-hexane extract of guava seed oil (GSO), to study its free-radical scavenging activity, and to monitor the changes in serum lipids and fatty acid profiles in rats that were fed GSO. The GSO was analyzed for phytochemicals using chromatographic methods. It was also tested for free-radical scavenging activity in hepatoma and neuroblastoma cells, and analyzed in terms of serum lipids and fatty acids. GSO was found to contain phenolic compounds (e.g., chlorogenic acid and its derivatives) and phytosterols (e.g., stimasterol, \u03b2-sitosterol and campesterol), and exerted radical-scavenging activity in cell cultures in a concentration-dependent manner. Long-term consumption of GSO did not increase cholesterol and triglyceride levels in rat serum, but it tended to decrease serum fatty acid levels in a concentration-dependent manner. This is the first study to report on the lipid, phytosterol and phenolic compositions, antioxidant activity, and the hepato- and neuro-protection of hydrogen peroxide-induced oxidative stress levels in the GSO extract.<\/jats:p>","DOI":"10.3390\/molecules25112474","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T02:16:27Z","timestamp":1590718587000},"page":"2474","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil"],"prefix":"10.3390","volume":"25","author":[{"given":"Adchara","family":"Prommaban","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niramon","family":"Utama-ang","sequence":"additional","affiliation":[{"name":"Department of Product Development Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anan","family":"Chaikitwattana","sequence":"additional","affiliation":[{"name":"Department of Herb and Extract Business Development, Tipco Biotech Company, Prachuapkhirikhan 77000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-2922","authenticated-orcid":false,"given":"Chairat","family":"Uthaipibull","sequence":"additional","affiliation":[{"name":"Protein-Ligand Engineering and Molecular Biology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathum Thani 12120, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Haematology, O\u2019Gormond Building, Institute of Cancer Research, Huntley Street, University College London, London WC1E 6BT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-8781","authenticated-orcid":false,"given":"Somdet","family":"Srichairatanakool","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2008.01.025","article-title":"Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology","volume":"117","author":"Gutierrez","year":"2008","journal-title":"J. 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