{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:15:41Z","timestamp":1768893341336,"version":"3.49.0"},"reference-count":41,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Grant Agency of The Ministry of Education, Science, Research and Sport of the Slovak Republic","award":["VEGA 2\/0103\/18, VEGA 2\/0079\/19, VEGA 2\/0162\/19"],"award-info":[{"award-number":["VEGA 2\/0103\/18, VEGA 2\/0079\/19, VEGA 2\/0162\/19"]}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-15-0565"],"award-info":[{"award-number":["APVV-15-0565"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We have investigated the vasoactive effects of the coupled nitro-sulfide signaling pathway in lobar arteries (LAs) isolated from the nephrectomized kidneys of cancer patients: normotensive patients (NT) and patients with arterial hypertension (AH). LAs of patients with AH revealed endothelial dysfunction, which was associated with an increased response to the exogenous NO donor, nitrosoglutathione (GSNO). The interaction of GSNO with the H2S donor triggered a specific vasoactive response. Unlike in normotensive patients, in patients with AH, the starting and returning of the vasorelaxation induced by the end-products of the H2S-GSNO interaction (S\/GSNO) was significantly faster, however, without the potentiation of the maximum. Moreover, increasing glycemia shortened the time required to reach 50% of the maximum vasorelaxant response induced by S\/GSNO products so modulating their final effect. Moreover, we found out that, unlike K+ channel activation, cGMP pathway and HNO as probable mediator could be involved in mechanisms of S\/GSNO action. For the first time, we demonstrated the expression of genes coding H2S-producing enzymes in perivascular adipose tissue and we showed the localization of these enzymes in LAs of normotensive patients and in patients with AH. Our study confirmed that the heterogeneity of specific nitroso-sulfide vasoactive signaling exists depending on the occurrence of hypertension associated with increased plasma glucose level. Endogenous H2S and the end-products of the H2S-GSNO interaction could represent prospective pharmacological targets to modulate the vasoactive properties of human intrarenal arteries.<\/jats:p>","DOI":"10.3390\/molecules25122886","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T10:54:59Z","timestamp":1592996099000},"page":"2886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Arterial Hypertension and Plasma Glucose Modulate the Vasoactive Effects of Nitroso-Sulfide Coupled Signaling in Human Intrarenal Arteries"],"prefix":"10.3390","volume":"25","author":[{"given":"Sona","family":"Cacanyiova","sequence":"first","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Krskova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Zorad","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Frimmel","sequence":"additional","affiliation":[{"name":"Institute for Heart Research, Center of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Drobna","sequence":"additional","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Valaskova","sequence":"additional","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"},{"name":"Institute of Pathophysiology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Misak","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Golas","sequence":"additional","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Breza","sequence":"additional","affiliation":[{"name":"Department of Urology, Derer\u2019s University Hospital, 833 05 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Jan","family":"Breza","sequence":"additional","affiliation":[{"name":"Department of Urology, Derer\u2019s University Hospital, 833 05 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Berenyiova","sequence":"additional","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1097\/00004872-200310000-00015","article-title":"The role of hydrogen sulfide generation in the pathogenesisof hypertension in rats induced by inhibition of nitric oxide synthase","volume":"21","author":"Zhong","year":"2003","journal-title":"J. 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