{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:27:39Z","timestamp":1791624459347,"version":"4.3.4"},"reference-count":106,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451-03-68\/2020-14\/200032"],"award-info":[{"award-number":["451-03-68\/2020-14\/200032"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Marrubium vulgare is a plant with high bioactive potential. It contains marrubiin, a labdane diterpene that is characteristic for this genus, as well as a complex mixture of phenolic compounds. According to numerous studies, M. vulgare acts as a good antioxidant agent, and due to this, it could potentially be useful in treatments of cancer, diabetes mellitus, and liver diseases. In addition, its anti-inflammatory, wound-healing, antihypertensive, hypolipidemic, and sedative potential are discussed. Apart from that, its antimicrobial activity, especially against Gram+ bacteria, fungi, herpes simplex virus, and parasites such as Toxoplasma gondii, Trichomonas vaginalis, and Plasmodium berghei-berghei was recorded. Additionally, it could be used as a chicken lice repellent, herbicide, and natural insecticide against mosquito larvae and natural molluscicide. In veterinary medicine, M. vulgare can be used as an anthelmintic against the eggs and larvae of bovine strongyles parasites, and as an antibiotic against bovine mastitis caused by resistant bacterial strains. Due to the mentioned benefits, there is a tendency for the cultivation of M. vulgare in order to ensure high-quality raw material, but more firm scientific evidence and well-designed clinical trials are necessary for the well-established use of M. vulgare herb and its preparations.<\/jats:p>","DOI":"10.3390\/molecules25122898","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T10:54:59Z","timestamp":1592996099000},"page":"2898","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Marrubium vulgare L.: A Phytochemical and Pharmacological Overview"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-1412","authenticated-orcid":false,"given":"Milica","family":"A\u0107imovi\u0107","sequence":"first","affiliation":[{"name":"Institute of Field and Vegetable Crops Novi Sad, Maksima Gorkog 30, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Jeremi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad 21000, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-5820","authenticated-orcid":false,"given":"Neboj\u0161a","family":"Salaj","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad 21000, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Gavari\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad 21000, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-1768","authenticated-orcid":false,"given":"Biljana","family":"Kiprovski","sequence":"additional","affiliation":[{"name":"Institute of Field and Vegetable Crops Novi Sad, Maksima Gorkog 30, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Sikora","sequence":"additional","affiliation":[{"name":"Institute of Field and Vegetable Crops Novi Sad, Maksima Gorkog 30, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7201-4802","authenticated-orcid":false,"given":"Tijana","family":"Zeremski","sequence":"additional","affiliation":[{"name":"Institute of Field and Vegetable Crops Novi Sad, Maksima Gorkog 30, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"ref_1","unstructured":"Biotechnology in Agriculture and Forestry, and Bajaj, Y.P.S. (1999). Marrubium vulgare (White Horehound): In vitro culture, and the production of diterpene marrubiin and other secondary metabolites. Medicinal and Aromatic Plants XI, Springer."},{"key":"ref_2","unstructured":"EMA\u2014European Medicines Agency, Committee on Herbal Medicinal Products (HMPC) (2013). Community Herbal Monograph on Marrubium vulgare L., herba, HMPC. EMA\/HMPC\/604271\/2012."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5455\/jice.20170713060840","article-title":"Marrubium vulgare L.: A review on phytochemical and pharmacological aspects","volume":"6","author":"Lodhi","year":"2017","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"ref_4","first-page":"7","article-title":"A taxonomical, morphological and pharmacological review of Marrubium vulgare L., an old medicinal plant in Iran","volume":"17","author":"Ahvazi","year":"2018","journal-title":"J. Med. Plants"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.20307\/nps.2019.25.2.81","article-title":"Essential oil of Marrubium vulgare: Chemical composition and biological activities. A review","volume":"25","author":"Yabrir","year":"2019","journal-title":"Nat. Prod. Sci."},{"key":"ref_6","first-page":"85","article-title":"Morphological differentiation of non-glandular and glandular trichomes on Marrubium vulgare L.","volume":"6","author":"Dmitruk","year":"2014","journal-title":"Mod. Phytomorphol."},{"key":"ref_7","first-page":"63","article-title":"Cropping evaluation of white horehound (Marrubium vulgare L.), grown from sowing and seedling","volume":"55","author":"Zawislak","year":"2009","journal-title":"Herba Pol."},{"key":"ref_8","first-page":"46","article-title":"Effect of nitrogen and potassium biofertilization on growth, yield and essential oil production of white horehound, Marrubium vulgare L. Plant","volume":"5","author":"Omer","year":"2013","journal-title":"J. Hortic. Sci. Ornam. Plants"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1300\/J044v03n01_02","article-title":"Influence of supplemental lighting and irrigation on mineral composition, growth and premarrubin content of horehound, Marrubium vulgare L.","volume":"3","author":"Bergeron","year":"1995","journal-title":"J. Herbs Species Med. Plants"},{"key":"ref_10","unstructured":"Weiss, J., Ainsworth, N., and Faithfull, I. (2008). Horehound, Marrubium vulgare. Best Practice Management Guide for Environmental Weeds."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.17129\/botsci.778","article-title":"Copper-induced changes in nutrient uptake, enzymatic and non-enzymatic antioxidant systems in horehound (Marrubium vulgare L.)","volume":"95","author":"Amri","year":"2017","journal-title":"Bot. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.15244\/pjoes\/64792","article-title":"How salt stress represses the biosynthesis of marrubiin and disturbs the antioxidant activity of Marrubium vulgare L.","volume":"26","author":"Rezgui","year":"2017","journal-title":"Pol. J. Environ. Stud."},{"key":"ref_13","first-page":"17","article-title":"Identification of the effects of boron stress on Marrubium vulgare L. (Lamiaceae)","volume":"1","author":"Ardic","year":"2018","journal-title":"Int. J. Environ. Res. Technol."},{"key":"ref_14","first-page":"7","article-title":"The pharmacognostical evaluation of the Marrubium vulgare Linn collected from the Pulwama district of Jammu and Kashmir State of India","volume":"8","author":"Mittal","year":"2016","journal-title":"J. Chem. Pharm. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.indcrop.2014.06.049","article-title":"Phytochemical profiling, in vitro evaluation of total phenolic contents and antioxidant properties of Marrubium vulgare (horehound) leaves of plants growing in Algeria","volume":"61","author":"Madani","year":"2014","journal-title":"Ind. Crops Prod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1080\/14786410802280976","article-title":"A new monoterpene acid from Marrubium vulgare with potential antihepatotoxic activity","volume":"24","author":"Ahmed","year":"2010","journal-title":"Nat. Prod. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S1308","DOI":"10.1016\/S2221-1691(12)60406-7","article-title":"Lead findings from whole plant of Marrubium vulgare L. with hepatoprotective potentials through in silico methods","volume":"2","author":"Verma","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_18","first-page":"2393","article-title":"Extraction and evaluation of the anti-inflammatory activity of six compounds of Marrubium vulgare L.","volume":"15","author":"Neamah","year":"2018","journal-title":"Biosci. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1055\/s-2006-957451","article-title":"Accumulation of furanic labdane diterpenes in Marrubium vulgare and Leonorus cardiaca","volume":"64","author":"Knoss","year":"1998","journal-title":"Planta Med."},{"key":"ref_20","first-page":"903","article-title":"Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst","volume":"9","author":"Shaheen","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"ref_21","first-page":"585","article-title":"The diterpenoids of the genus Marrubium (Lamiaceae)","volume":"1","author":"Piozzi","year":"2006","journal-title":"Nat. Prod. Commun."},{"key":"ref_22","first-page":"108","article-title":"Marrubium vulgare ethanolic extract induces proliferation block, apoptosis and cytoprotective autophagy in cancer cells in vitro","volume":"62","author":"Paunovic","year":"2016","journal-title":"Cell. Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Amri, B., Martino, E., Vitulo, F., Corana, F., Kaab, L.B.B., Rui, M., Rossi, D., Mori, M., Rossi, S., and Collina, S. (2017). Marrubium vulgare L. leaves extract: Phytochemical composition, antioxidant and wound healing properties. Molecules, 22.","DOI":"10.3390\/molecules22111851"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.phytol.2015.07.005","article-title":"Labdane diterpenoids from Marrubium vulgare","volume":"13","author":"Masoodi","year":"2015","journal-title":"Phytochem. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.15171\/apb.2016.019","article-title":"Chromatographic fingerprint analysis of marrubiin in Marrubium vulgare L. via HPTLC technique","volume":"6","author":"Yousefi","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"ref_26","first-page":"253","article-title":"Assessment of hemostatic activity of the aqueous extract of leaves of Marrubium vulgare L., a Mediterranean Lamiaceae Algeria","volume":"2","author":"Ghedadba","year":"2016","journal-title":"Int. J. Health Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.fitote.2011.11.005","article-title":"Compositional analysis and in vivo anti-diabetic activity of wild Algerian Marrubium vulgare L. infusion","volume":"83","author":"Boudjelal","year":"2012","journal-title":"Fitoterapia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2298\/MPNS1802021S","article-title":"Biomedical potential of horehound extract (Marrubium vulgare, Lamiaceae)","volume":"71","author":"Salaj","year":"2018","journal-title":"Med. Pregl."},{"key":"ref_29","first-page":"2106","article-title":"Phenolic content and allelopathic potential of leaves and rizosphere soil aqueous extracts of white horehound (Maribum vulgare L.)","volume":"39","author":"Dallali","year":"2017","journal-title":"J. New Sci. Agric. Biotechnol."},{"key":"ref_30","first-page":"711","article-title":"In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract","volume":"23","author":"Okur","year":"2019","journal-title":"J. Res. Pharm."},{"key":"ref_31","first-page":"252","article-title":"Evaluation of in vitro antioxidant and in vivo anti-inflammatory potential of white horehound (Marrubium vulgare L.) leaves","volume":"41","author":"Ghedadba","year":"2016","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gavari\u0107, A., Vladi\u0107, J., Ambrus, R., Joki\u0107, S., Szabo-Revesz, P., Tomi\u0107, M., Bla\u017ei\u0107, M., and Vidovi\u0107, S. (2019). Spray drying of a subcritical extract using Marrubium vulgare as a method of choice for obtaining high quality powder. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11100523"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/sj.bjp.0705561","article-title":"Characterisation of marubenol, a diterpene extracted from Marrubium vulgare, as an L-type calcium channel blocker","volume":"140","author":"Wibo","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/j.2042-7158.2011.01321.x","article-title":"Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae)","volume":"63","author":"Oliveira","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"9049","DOI":"10.3390\/molecules18089049","article-title":"Marrubiin","volume":"18","author":"Popoola","year":"2013","journal-title":"Molecules"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jep.2006.05.023","article-title":"Antioedematogenic effect of marrubiin obtained from Marrubium vulgare","volume":"108","author":"Stulzer","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1055\/s-2003-37042","article-title":"The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgare","volume":"69","author":"Morel","year":"2003","journal-title":"Planta Med."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Dewick, M.P. (2009). Medicinal Natural Products: A Biosynthetic Approach, John Wiley & Sons, Ltd.. [3rd ed.].","DOI":"10.1002\/9780470742761"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.indcrop.2015.07.069","article-title":"Antioxidant properties and phenolic variation in wild populations of Marrubium vulgare L. (Lamiaceae)","volume":"76","author":"Boulila","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0378-8741(01)00415-9","article-title":"Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare","volume":"79","author":"Sahpaz","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.foodchem.2011.07.112","article-title":"Isolation, identification and activity of natural antioxidants from horehound (Marrubium vulgare L.) cultivated in Lithuania","volume":"130","author":"Pukalskas","year":"2012","journal-title":"Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1023\/B:CONC.0000011128.64886.f4","article-title":"Comparative phytochemical investigation of the composition and content of biologically active substances in Marrubium vulgare and M. alternidens","volume":"39","author":"Kurbatova","year":"2003","journal-title":"Chem. Nat. Compd."},{"key":"ref_43","unstructured":"Nawal, H.M., and Atta, E.M. (2013, January 17\u201318). Cytotoxic and antioxidant activity of Marrubium vulgare and flavonoid constituents. Proceedings of the 2nd International Conference on Chemical, Environmental and Biological Sciences, Dubai, UAE."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1016\/0031-9422(89)80307-3","article-title":"Flavonoid lactates from leaves of Marrubium vulgare","volume":"28","author":"Nawwar","year":"1989","journal-title":"Phytochemistry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-0029-1185972","article-title":"Activity of ladanein on leukemia cell lines and its occurrence in Marrubium vulgare","volume":"76","author":"Alkhatib","year":"2010","journal-title":"Planta Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Karunanithi, P.S., Dhanlta, P., Addison, J.B., Tong, S., Fiehn, O., and Zerbe, P. (2019). Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin byosynthesis in the medicinal plant Marrubium vulgare. BMC Plant Biol., 19.","DOI":"10.1186\/s12870-019-1702-5"},{"key":"ref_47","unstructured":"WHO Organization (2011). Quality Control Methods for Herbal Materials, World Health Organization."},{"key":"ref_48","unstructured":"Farrukh, I.A., and Owais, M. (2006). Quality control, screening, toxicity, and regulation of herbal drugs. Modern Phytomedicine: Turning Medicinal Plants into Drugs, Wiley-VCH Verlag GmbH & Co. KGaA."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.solener.2019.07.003","article-title":"Thin-layer solar drying characteristics of Moroccan horehound leaves (Marrubium vulgare L.) under natural and forced convection solar drying","volume":"188","author":"Bahammou","year":"2019","journal-title":"Sol. Energy"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1080\/0972060X.2016.1191973","article-title":"Modeling and optimization of the operating conditions of Marrubium vulgare L. essential oil extraction process: Kinetic parameters estimation through genetic algorithms","volume":"19","author":"Rezazi","year":"2016","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/pca.2820","article-title":"The use of a microwave-assisted solvent extraction coupled with HPLC-UV\/PAD to assess the quality of Marrubium vulgare L. (white horehound) herbal raw material","volume":"30","author":"Martino","year":"2019","journal-title":"Phytochem. Anal."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF02466478","article-title":"An improved extraction of marrubiin from Marrubium vulgare","volume":"47","author":"Rodrigues","year":"1998","journal-title":"Chromatographia"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4236\/ijoc.2014.45032","article-title":"Optimization of extraction conditions of some phenolic compounds from white horehound (Marrubium vulgare L.) leaves","volume":"4","author":"Bouterfas","year":"2014","journal-title":"Int. J. Org. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.egypro.2017.11.180","article-title":"Kinetic study and optimization of extraction process condition","volume":"139","author":"Rezazi","year":"2017","journal-title":"Energy Procedia"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1080\/0972060X.2018.1484820","article-title":"Intensification of essential oil extraction of the Marrubium vulgare using pulsed electric field","volume":"21","author":"Miloudi","year":"2018","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"ref_56","unstructured":"Steinmetz, E.F. (1954). Materia Medica Vegetabilis, Published by Author."},{"key":"ref_57","unstructured":"Thomas, D.L., and Thomas, L.B. (1920). Kentucky Superstitions, Princeton University Press."},{"key":"ref_58","unstructured":"Wichtl, M. (2001). Herbal Drugs and Phytopharmaceuticals, CRC Press."},{"key":"ref_59","first-page":"199","article-title":"Assessment of methanolic extract of Marrubium vulgare for anti-inflammatory, analgesic and anti-microbiologic activities","volume":"3","author":"Kanyonga","year":"2011","journal-title":"J. Chem. Pharm. Res."},{"key":"ref_60","first-page":"565","article-title":"Hepatoprotective activity of Marrubium vulgare against paracetamol induced toxicity","volume":"7","author":"Akther","year":"2013","journal-title":"J. Pharm. Res."},{"key":"ref_61","unstructured":"Commission, E.P. (2014). European Pharmacopoeia 8th Edition: Supplement 8.0, Council of Europe."},{"key":"ref_62","first-page":"3908","article-title":"Chemical composition and antioxidant activity of Marrubium vulgare L. essential oil from Tunisia","volume":"10","author":"Kadri","year":"2011","journal-title":"Afr. J. Biotechnol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.apjtm.2017.01.010","article-title":"Effects of the hydro-ethanolic extract of Marrubium vulgare in female rats","volume":"10","author":"Aouni","year":"2017","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_64","first-page":"74","article-title":"The effects of alcoholic extract of Marrubum vulgare on hormonal parameters in female rat model of polycystic ovarian syndrome","volume":"24","author":"Mokhtari","year":"2014","journal-title":"Med. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"628","DOI":"10.2174\/1389200219666180404095849","article-title":"Herbs with Potential Nephrotoxic Effects According to the Traditional Persian Medicine: Review and Assessment of Scientific Evidence","volume":"19","author":"Kolangi","year":"2018","journal-title":"Curr. Drug Metab."},{"key":"ref_66","first-page":"28","article-title":"Antioxidants properties of natural and synthetic chemical compounds: Therapeutic effects on biological system","volume":"3","author":"Mbah","year":"2019","journal-title":"Acta Sci. Pharm. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"17","DOI":"10.56431\/p-4r37h0","article-title":"Essential oil composition and antioxidant activity of Marrubium vulgare L. growing wild in Eastern Algeria","volume":"9","author":"Abadi","year":"2013","journal-title":"Int. Lett. Chem. Phys. Astron."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"100927","DOI":"10.1016\/j.mycmed.2020.100927","article-title":"Antioxidant and Antifungal Activities of Marrubiin, Extracts and Essential Oil from Marrubium vulgare L. against Pathogenic Dermatophyte Strains","volume":"30","author":"Rezgui","year":"2020","journal-title":"J. Mycol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1016\/j.fct.2010.06.028","article-title":"Isolation and characterization of a new steroid derivative as a powerful antioxidant from Cleome arabica in screening the in vitro antioxidant capacity of 18 Algerian medicinal plants","volume":"48","author":"Djeridane","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/(SICI)1521-4133(199910)101:10<395::AID-LIPI395>3.0.CO;2-L","article-title":"Antioxidant activity of horehound (Marrubium vulgare L.) grown in Lithuania","volume":"101","author":"Weel","year":"1999","journal-title":"Lipid"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.pharma.2016.07.002","article-title":"Antioxidant activity and total phenolic and flavonoids content variations of leaves extracts of white Horehound (Marrubium vulgare Linn\u00e9) from three geographical origins","volume":"74","author":"Bouterfas","year":"2016","journal-title":"Ann. Pharm. Fr."},{"key":"ref_72","first-page":"1664","article-title":"Potential effect of Marrubium vulgare L. extracts on CCl4 model induced hepatotoxicity in albino mice","volume":"2","author":"Ibrahim","year":"2014","journal-title":"World J. Pharm. Sci."},{"key":"ref_73","first-page":"168","article-title":"Utilization of Marrubium vulgare extract as a therapeutic to hepatic damage induced by carbon tetrachloride in rats","volume":"7","author":"Alsanie","year":"2018","journal-title":"Int. J. Pharm. Res. Allied Sci."},{"key":"ref_74","first-page":"247","article-title":"Antixepatoxic effect of Marrubium vulgare and Withania somnifera extracts on carbon tetrachloride-induced hepatotoxicity in rats","volume":"1","author":"Elberry","year":"2010","journal-title":"J. Basic Clin. Pharm."},{"key":"ref_75","first-page":"1613457","article-title":"Ethnopharmacological survey of herbal remedies used for the treatment of cancer in the greater Casablanca-Morocco","volume":"10","author":"Bourhia","year":"2019","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/ptr.5661","article-title":"An Insight into a Blockbuster Phytomedicine; Marrubium vulgare L. Herb. More of a Myth than a Reality?","volume":"30","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1476-511X-10-161","article-title":"The in-vitro evaluation of antibacterial, antifungal and cytotoxic properties of Marrubium vulgare L. essential oil grown in Tunisia","volume":"10","author":"Zarai","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Tlili, H., Hanen, N., Ben Arfa, A., Neffati, M., Boubakri, A., Buonocore, D., Dossena, M., Verri, M., and Doria, E. (2019). Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia. PLoS ONE, 14.","DOI":"10.1101\/551515"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/2211-5463.12755","article-title":"Cytotoxic Activity of Methanolic Fractions of Different Marrubium spp. against Melanoma Cells Is Independent of Antioxidant Activity and Total Phenolic Content","volume":"10","author":"Kozyra","year":"2020","journal-title":"FEBS Open Bio"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"111826","DOI":"10.1016\/j.jep.2019.111826","article-title":"Prediction of Potential Cancer-Related Molecular Targets of North African Plants Constituents Using Network Pharmacology-Based Analysis","volume":"238","author":"Shawky","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_81","first-page":"S959","article-title":"A methanolic extract of Marrubium vulgare L. suppresses inflammatory responses in isoproterenol induced myocardial infarction in rat","volume":"7","author":"Rameshrad","year":"2012","journal-title":"Res. Pharm. Sci."},{"key":"ref_82","first-page":"21","article-title":"Marrubium vulgare L. methanolic extract inhibits inflammatory response and prevents cardiomyocyte fibrosis in isoproterenol-induced acute myocardial infarction in rats","volume":"4","author":"Yousefi","year":"2014","journal-title":"BioImpacts"},{"key":"ref_83","unstructured":"Ajedi, A.S.S., Widodo, N., Widyarti, S., and Rifai, M. (2018, January 30\u201331). Immunomodulatory effect of Moringa oleifera and Marrubium vulgare leaf aqueous extracts in BALB\/C mice infected with Salmonella typhimurium. Proceedings of the 144th the IRES International Conference, Bali, Indonesia."},{"key":"ref_84","first-page":"422","article-title":"Effect of Marrubium vulgare L. aerial parts aqueous and ethanolic extracts on morphine withdrawal syndrome in mice","volume":"3","author":"Hosseinzadeh","year":"2007","journal-title":"Pharmacologyonline"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jep.2017.01.023","article-title":"Ethnobotanical Survey of Medicinal Plants Used in the Traditional Treatment of Diabetes in Chtouka Ait Baha and Tiznit (Western Anti-Atlas), Morocco","volume":"98","author":"Barkaoui","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"111841","DOI":"10.1016\/j.jep.2019.111841","article-title":"A review of Algerian medicinal plants used in the treatment of diabetes","volume":"238","author":"Hamza","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Villanueva, J.R., Esteban, J.M., and Villanueva, L.R. (2017). A reassessment of the Marrubium vulgare L. herb\u2019s potential role in diabetes mellitus type 2: First results guide in investigation toward new horizons. Medicines, 4.","DOI":"10.3390\/medicines4030057"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Hellal, K., Maulidiani, M., Ismail, I.S., Tan, C.P., and Abas, F. (2020). Antioxidant, \u03b1-Glucosidase, and Nitric Oxide Inhibitory Activities of Six Algerian Traditional Medicinal Plant Extracts and 1 H-NMR-Based Metabolomics Study of the Active Extract. Molecules, 25.","DOI":"10.3390\/molecules25051247"},{"key":"ref_89","first-page":"258","article-title":"Antidiabetic activities of methanolic extracts of Marrubium vulgare leaves in rats","volume":"4","author":"Chakir","year":"2015","journal-title":"Int. J. Pharm. Phytopharm. Res."},{"key":"ref_90","first-page":"42","article-title":"Hypoglycemic effects of Marrubium vulgare (Rubia) in experimentally induced autoimmune diabetes mellitus","volume":"44","author":"Elmhdwi","year":"2014","journal-title":"Int. Res. J. Biochem. Bioinform."},{"key":"ref_91","first-page":"907","article-title":"Screening of the Anti-hyperglycemic Activity of Some Medicinal Plants of Jordan","volume":"30","author":"Alkofahi","year":"2017","journal-title":"Pak. J. Pharm Sci."},{"key":"ref_92","first-page":"1","article-title":"The effect of Marrubium vulgare on contractile reactivity of aorta in diabetic rats","volume":"7","author":"Dehkordi","year":"2012","journal-title":"ARYA Atheroscler. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.phymed.2004.01.006","article-title":"Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics","volume":"11","year":"2004","journal-title":"Phytomedicine"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1081\/CEH-200031818","article-title":"Comparative study of the antihypertensive activity of Marrubium vulgare and of the dihydropyridine calcium antagonist amlodipine in spontaneously hypertensive rat","volume":"26","author":"Lyoussi","year":"2004","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.apjtm.2016.03.038","article-title":"Evaluation of Hypolipidemic Marrubium Vulgare Effect in Triton WR-1339-induced Hyperlipidemia in Mice","volume":"9","author":"Ibrahim","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1080\/07853890.2017.1366042","article-title":"Nutraceutical Approaches to Metabolic Syndrome","volume":"49","author":"Sirtori","year":"2017","journal-title":"Ann. Med."},{"key":"ref_97","first-page":"270","article-title":"Chemical characterization and antibacterial activity of phases obtained from extracts of Artemisia herba alba, Marrubium vulgare and Pinus pinaster","volume":"7","author":"Djerrou","year":"2015","journal-title":"Int. J. Pharmacogn. Phytochem. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.mycmed.2016.02.019","article-title":"Does the sampling locality influence on the antifungal activity of the flavonoids of Marrubium vulgare against Aspergillus niger and Candida albicans?","volume":"26","author":"Bouterfas","year":"2016","journal-title":"J. Mycol. Med."},{"key":"ref_99","first-page":"106","article-title":"Phytochemical screening and antiviral activity of Marrubium vulgare","volume":"10","author":"Fayyad","year":"2014","journal-title":"Malays. J. Microbiol."},{"key":"ref_100","first-page":"44","article-title":"The therapeutic effect of Marrubium vulgare, Salvia officinalis and Lippia citrodora in killing of Toxoplasma gondii tachyzoite and evaluation by MTT assay","volume":"39","author":"Bahadory","year":"2018","journal-title":"Med. J. Tabriz Univ. Med. Sci. Health Serv."},{"key":"ref_101","first-page":"e67003","article-title":"Investigation of in vitro efficacy of Marrubium vulgare L. essential oil and extracts against Trichomonas vaginalis","volume":"20","author":"Akbari","year":"2018","journal-title":"Zahedan J. Res. Med. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"132","DOI":"10.26538\/tjnpr\/v2i3.6","article-title":"In vivo antiplasmodial activity of ethanol leaf extract of Marrubium vulgare L. (Lamiaceae) in Plasmodium berghei-berghei infected mice","volume":"2","author":"Abdussalam","year":"2018","journal-title":"Trop. J. Nat. Prod. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"262","DOI":"10.5152\/tpd.2018.5972","article-title":"In vitro anthelmintic effects of aqueous and ethanolic extracts of Marrubium vulgare leaves against bovine digestive strongyles","volume":"42","author":"Moussouni","year":"2018","journal-title":"Turkiye Parazitol. Derg."},{"key":"ref_104","first-page":"154","article-title":"A study of ethno-veterinary medicinal plants and in vitro antimicrobial activities against bovine mastitis isolated bacterial pathogens in Algeria","volume":"76","author":"Saidi","year":"2019","journal-title":"Bull. UASVM Vet. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.egypro.2015.07.739","article-title":"Larvicidal effect of Marrubium vulgare on Culex pipiens in eastern Algeria","volume":"74","author":"Aouati","year":"2015","journal-title":"Energy Procedia"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-2006-961873","article-title":"Volatile oil of Marrubium vulgare and its anti-schistosomal activity","volume":"55","author":"Saleh","year":"1989","journal-title":"Planta Med."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/12\/2898\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:42:02Z","timestamp":1760175722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/12\/2898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,24]]},"references-count":106,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["molecules25122898"],"URL":"https:\/\/doi.org\/10.3390\/molecules25122898","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,24]]}}}