{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T20:59:25Z","timestamp":1788037165430,"version":"build-2784847793"},"reference-count":75,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cancer is the second leading cause of death globally, and despite the advances in drug development, it is still necessary to develop new plant-derived medicines. Compared with using conventional chemical drugs to decrease the side effects induced by chemotherapy, natural herbal medicines have many advantages. The present study aimed to discover the potential cytotoxicity of ethanol extract and its derived fractions (chloroform, ethyl acetate, butanol, and aqueous) of Adenosma bracteosum Bonati. (A. bracteosum) on human large cell lung carcinoma (NCI-H460) and hepatocellular carcinoma (HepG2). Among these fractions, the chloroform showed significant activity in the inhibition of proliferation of both cancerous cells because of the presence of bioactive compounds including xanthomicrol, 5,4\u2019-dihydroxy-6,7,8,3\u2019-tetramethoxyflavone, and ursolic acid which were clearly revealed by nuclear magnetic resonance spectroscopy (1H-NMR, 13C-NMR, Heteronuclear Multiple Bond Coherence, and Heteronuclear Single Quantum Coherence Spectroscopy) analyses. According to the radical scavenging capacity, the 5,4\u2019-dihydroxy-6,7,8,3\u2019-tetramethoxyflavone compound (AB2) exhibited the highest anticancer activity on both NCI-H460 and HepG2 with IC50 values of 4.57 \u00b1 0.32 and 5.67 \u00b1 0.09 \u00b5g\/mL respectively, followed by the ursolic acid with the lower percent inhibition at 13.05 \u00b1 0.55 and 10.00 \u00b1 0.16 \u00b5g\/mL, respectively (p &lt; 0.05). Remarkably, the AB2 compound induced to significant increase in the production of reactive oxygen species accompanied by attenuation of mitochondrial membrane potential, thus inducing the activation of caspase-3 activity in both human lung and liver cancer cells. These results suggest that A. bracteosum is a promising source of useful natural products and AB2 offers opportunities to develop the novel anticancer drugs.<\/jats:p>","DOI":"10.3390\/molecules25122912","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T10:54:59Z","timestamp":1592996099000},"page":"2912","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Anticancer Activity of Novel Plant Extracts and Compounds from Adenosma bracteosum (Bonati) in Human Lung and Liver Cancer Cells"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3119-1802","authenticated-orcid":false,"given":"Ngoc Hong","family":"Nguyen","sequence":"first","affiliation":[{"name":"CirTech Institute, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City 700000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-7338","authenticated-orcid":false,"given":"Qui Thanh Hoai","family":"Ta","sequence":"additional","affiliation":[{"name":"Institute of Research and Development, Duy Tan University, Danang 550000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang Thang","family":"Pham","sequence":"additional","affiliation":[{"name":"Institute of Applied Science, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City 700000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Ngoc Han","family":"Luong","sequence":"additional","affiliation":[{"name":"Institute of Applied Science, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City 700000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Trung","family":"Phung","sequence":"additional","affiliation":[{"name":"Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuc-Huy","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, University of Education, Ho Chi Minh City 700000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-7865","authenticated-orcid":false,"given":"Van Giau","family":"Vo","sequence":"additional","affiliation":[{"name":"Bionanotechnology Research Group, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam"},{"name":"Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. 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