{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:27:32Z","timestamp":1792308452789,"version":"4.4.0"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Two new series of hybrid quinoline-sulfonamide complexes (M2+: Zn2+, Cu2+, Co2+ and Cd2+) derivatives (QSC) were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by complexation with metal acetate (Cu2+, Co2+ and Cd2+) or chloride (Zn2+). The synthesized QSC compounds were characterized by FTIR and NMR spectroscopy and by X-ray diffraction on single crystal. The QSC compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising. In this respect, the hybrid N-(quinolin-8-yl)-4-chloro-benzenesulfonamide cadmium (II), considered as leading structure for further studies, has an excellent antibacterial activity against Staphylococcus aureus ATCC25923 (with a diameters of inhibition zones of 21 mm and a minimum inhibitory concentration (MIC) of 19.04 \u00d7 10\u22125 mg\/mL), a very good antibacterial activity against Escherichia coli ATCC25922 (with a diameters of inhibition zones of 19 mm and a MIC of 609 \u00d7 10\u22125 mg\/mL), and again an excellent antifungal activity against Candida albicans ATCC10231 (with a diameters of inhibition zones of 25 mm and a MIC of 19.04 \u00d7 10\u22125 mg\/mL).<\/jats:p>","DOI":"10.3390\/molecules25122946","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T16:06:54Z","timestamp":1593533214000},"page":"2946","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Hybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity"],"prefix":"10.3390","volume":"25","author":[{"given":"Dumitrela","family":"Diaconu","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, 700506 Iasi, Romania"},{"name":"Institute of Interdisciplinary Research\u2014CERNESIM Center, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-8686","authenticated-orcid":false,"given":"Violeta","family":"Mangalagiu","sequence":"additional","affiliation":[{"name":"Institute of Interdisciplinary Research\u2014CERNESIM Center, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Amariucai-Mantu","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilichia","family":"Antoci","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Levente","family":"Giuroiu","sequence":"additional","affiliation":[{"name":"Endodontics, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universit\u0103\u0163ii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-5076","authenticated-orcid":false,"given":"Ionel I.","family":"Mangalagiu","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, 700506 Iasi, Romania"},{"name":"Institute of Interdisciplinary Research\u2014CERNESIM Center, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"ref_1","unstructured":"Brunton, L., Knollmann, B., and Hilal-Dandan, R. (2013). Goodman & Gilman\u2019s the Pharmacological Basis of Therapeutics, McGraw-Hill. [13th ed.]."},{"key":"ref_2","unstructured":"Silverman, R.B., and Holladay, M.W. (2014). 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