{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:54:15Z","timestamp":1764784455907,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Naftifine is used to treat fungal skin infections as it inhibits dermatophytes, which are the cause of onychomycosis. However, naftifine\u2019s ability to permeate the human nail barrier has not been investigated, thus, the antimycotic potential is not clearly established. This work aims to evaluate the effect of penetration enhancing factors on the accumulation of naftifine hydrochloride through human nail clippings. Naftifine polymeric nail lacquers with Eudragit RL100 were developed as a suitable delivery system. Low penetration of naftifine into nail has been determined as less than 10% of applied drug dose accumulated in the nail layers. Incorporation of thioglycolic acid into formulations resulted in increased accumulation of antifungal agent in the nail layers by 100% compared with a control group. Salicylic acid did not effect naftifine accumulation in the human nail. The permeation of naftifine through the nail increased by threefold when the thioglycolic acid-containing formulation was applied and the nail was pretreated with a fractional CO2 laser. Structural changes of the nail barrier, induced by fractional CO2 laser, were visualized by microscopy. The results suggest, that naftifine nail penetration could be significantly increased when physical and chemical enhancing factors are applied.<\/jats:p>","DOI":"10.3390\/molecules25133043","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T11:07:42Z","timestamp":1594033662000},"page":"3043","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Potential of Naftifine Application for Transungual Delivery"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6890-3535","authenticated-orcid":false,"given":"Indr\u0117","family":"\u0160veikauskait\u0117","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukil\u0117li\u0173 pr. 13, Kaunas 50161, Lithuania"},{"name":"Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Sukil\u0117li\u0173 pr. 13, Kaunas 50161, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitalis","family":"Briedis","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukil\u0117li\u0173 pr. 13, Kaunas 50161, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1001\/jamadermatol.2014.2983","article-title":"Treatment of Nail Psoriasis: Best practice recommendations from the Medical Board of the National Psoriasis Foundation","volume":"151","author":"Crowley","year":"2015","journal-title":"JAMA Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kreijkamp-Kaspers, S., Hawke, K., Guo, L., Kerin, G., Bell-Syer, S.E., Magin, P., Bell-Syer, S.V., and Van Driel, M.L. 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