{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:04:20Z","timestamp":1789646660618,"version":"4.0.0"},"reference-count":84,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In low-income populations, neglected diseases are the principal cause of mortality. Of these, leishmaniasis and malaria, being parasitic, protozoan infections, affect millions of people worldwide and are creating a public health problem. The present work evaluates the leishmanicidal and antiplasmodial action of a series of twelve p-coumaric acid derivatives. Of the tested derivatives, eight presented antiparasitic activities 1\u20133, 8\u201312. The hexyl p-coumarate derivative (9) (4.14 \u00b1 0.55 \u03bcg\/mL; selectivity index (SI) = 2.72) showed the highest leishmanicidal potency against the Leishmania braziliensis amastigote form. The results of the molecular docking study suggest that this compound inhibits aldehyde dehydrogenase (ALDH), mitogen-activated kinase protein (MPK4), and DNA topoisomerase 2 (TOP2), all of which are key enzymes in the development of Leishmania braziliensis. The data indicate that these enzymes interact via Van der Waals bonds, hydrophobic interactions, and hydrogen bonds with phenolic and aliphatic parts of this same compound. Of the other compounds analyzed, methyl p-coumarate (64.59 \u00b1 2.89 \u03bcg\/mL; IS = 0.1) demonstrated bioactivity against Plasmodium falciparum. The study reveals that esters presenting a p-coumarate substructure are promising for use in synthesis of derivatives with good antiparasitic profiles.<\/jats:p>","DOI":"10.3390\/molecules25143178","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T05:10:30Z","timestamp":1595394630000},"page":"3178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Alkyl and Aryl Derivatives Based on p-Coumaric Acid Modification and Inhibitory Action against Leishmania braziliensis and Plasmodium falciparum"],"prefix":"10.3390","volume":"25","author":[{"given":"Susiany P.","family":"Lopes","sequence":"first","affiliation":[{"name":"PostGraduation Program in Technological Development and Innovation in Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa CEP 58051-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina M.","family":"Yepes","sequence":"additional","affiliation":[{"name":"PECET-Facultad de Medicina, Universidad de Antioquia, Medell\u00edn Calle 70 # 52-21, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-0035","authenticated-orcid":false,"given":"Yunierkis","family":"P\u00e9rez-Castillo","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias F\u00edsicas y Matem\u00e1ticas, Universidad de Las Am\u00e9ricas, Quito 170504, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-4931","authenticated-orcid":false,"given":"Sara M.","family":"Robledo","sequence":"additional","affiliation":[{"name":"PECET-Facultad de Medicina, Universidad de Antioquia, Medell\u00edn Calle 70 # 52-21, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-4896","authenticated-orcid":false,"given":"Dami\u00e3o P.","family":"de Sousa","sequence":"additional","affiliation":[{"name":"PostGraduation Program in Technological Development and Innovation in Medicines, Federal University of Para\u00edba, Jo\u00e3o Pessoa CEP 58051-970, Brazil"},{"name":"Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa CEP 58051-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.sajb.2019.05.025","article-title":"Evaluation of antiparasitary, cytotoxic and antioxidant activity and chemical analysis of Tarenaya spinosa (Jacq.) 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