{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:59:37Z","timestamp":1783699177237,"version":"3.55.0"},"reference-count":196,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"UEFISCDI","doi-asserted-by":"publisher","award":["PN-III-P1-1.1-TE-2016-1210"],"award-info":[{"award-number":["PN-III-P1-1.1-TE-2016-1210"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Vitamin B3, or niacin, is one of the most important compounds of the B-vitamin complex. Recent reports have demonstrated the involvement of vitamin B3 in a number of pivotal functions which ensure that homeostasis is maintained. In addition, the intriguing nature of its synthesis and the underlying mechanism of action of vitamin B3 have encouraged further studies aimed at deepening our understanding of the close link between the exogenous supply of B3 and how it activates dependent enzymes. This crucial role can be attributed to the gut microflora and its ability to shape human behavior and development by mediating the bioavailability of metabolites. Recent studies have indicated a possible interconnection between the novel coronavirus and commensal bacteria. As such, we have attempted to explain how the gastrointestinal deficiencies displayed by SARS-CoV-2-infected patients arise. It seems that the stimulation of a proinflammatory cascade and the production of large amounts of reactive oxygen species culminates in the subsequent loss of host eubiosis. Studies of the relationhip between ROS, SARS-CoV-2, and gut flora are sparse in the current literature. As an integrated component, oxidative stress (OS) has been found to negatively influence host eubiosis, in vitro fertilization outcomes, and oocyte quality, but to act as a sentinel against infections. In conclusion, research suggests that in the future, a healthy diet may be considered a reliable tool for maintaining and optimizing our key internal parameters.<\/jats:p>","DOI":"10.3390\/molecules25153323","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T11:26:01Z","timestamp":1595503561000},"page":"3323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Minireview Exploring the Biological Cycle of Vitamin B3 and Its Influence on Oxidative Stress: Further Molecular and Clinical Aspects"],"prefix":"10.3390","volume":"25","author":[{"given":"Bogdan","family":"Doroftei","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street, no 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cCuza Voda\u201d, Cuza Voda Street, no 34, 700038 Iasi, Romania"},{"name":"Origyn Fertility Center, Palace Street, no 3C, 700032 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-1765","authenticated-orcid":false,"given":"Ovidiu-Dumitru","family":"Ilie","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Biology, Alexandru Ioan Cuza University, Carol I Avenue, no 11, 700505 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana-Oana","family":"Cojocariu","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Biology, Alexandru Ioan Cuza University, Carol I Avenue, no 11, 700505 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alin","family":"Ciobica","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Biology, Alexandru Ioan Cuza University, Carol I Avenue, no 11, 700505 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Maftei","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street, no 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cCuza Voda\u201d, Cuza Voda Street, no 34, 700038 Iasi, Romania"},{"name":"Origyn Fertility Center, Palace Street, no 3C, 700032 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Grab","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street, no 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cCuza Voda\u201d, Cuza Voda Street, no 34, 700038 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8244-0522","authenticated-orcid":false,"given":"Emil","family":"Anton","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street, no 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cCuza Voda\u201d, Cuza Voda Street, no 34, 700038 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"McKenna","sequence":"additional","affiliation":[{"name":"York Hospital, Wigginton road Clifton, York YO31 8HE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitasha","family":"Dhunna","sequence":"additional","affiliation":[{"name":"Mid Yorkshrie Hospitals NHS Trust, Pinderfields Hospital, Wakefield WF1 4DG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Simionescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street, no 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cCuza Voda\u201d, Cuza Voda Street, no 34, 700038 Iasi, Romania"},{"name":"Origyn Fertility Center, Palace Street, no 3C, 700032 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Aguilera-M\u00e9ndez, A., Fern\u00e1ndez-Lainez, C., Ibarra-Gonz\u00e1lez, I., and Fernandez-Mejia, C. (2012). The chemistry and biochemistry of niacin (B3). B Vitamins and Folate: Chemistry, Analysis, Function and Effects, RSC Publishing.","DOI":"10.1039\/9781849734714-00108"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/ars.2007.1672","article-title":"NAD+\/NADH and NADP+\/NADPH in cellular functions and cell death: Regulation and biological consequences","volume":"10","author":"Ying","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1046\/j.1365-4362.2002.01551.x","article-title":"Pellagra and skin","volume":"41","author":"Karthikeyan","year":"2002","journal-title":"Int. J. Derm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-4632.2004.01959.x","article-title":"Pellagra: Dermatitis, dementia, and diarrhea","volume":"43","author":"Hegyi","year":"2004","journal-title":"Int. J. Derm."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0003-9861(55)90070-9","article-title":"Influence of nicotinic acid on serum cholesterol in man","volume":"54","author":"Altschul","year":"1955","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.0954-6820.1963.tb17457.x","article-title":"Studies on the effect of nicotinic acid on catecholamine stimulated lipolysis in adipose tissue in vitro","volume":"173","author":"Carlson","year":"1963","journal-title":"Acta Med. Scand."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.0954-6820.1962.tb07203.x","article-title":"The effect of nicotinic acid on the plasma free fatty acids demonstration of a metabolic type of sympathicolysis","volume":"172","author":"Carlson","year":"1962","journal-title":"Acta Med. Scand."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0024-3205(64)90149-3","article-title":"Initial distribution in mice of 3H-labeled nicotinic acid studied with autoradiography","volume":"3","author":"Carlson","year":"1964","journal-title":"Life Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/S0021-9258(18)93503-9","article-title":"Effects of lipolytic and antilipolytic substances on adenosine 3\u2032,5\u2032-monophosphate levels in isolated fat cells","volume":"243","author":"Butcher","year":"1968","journal-title":"J. Biol. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00569726","article-title":"Regulation of adenylate cyclase activity in hamster adipocytes","volume":"312","author":"Aktories","year":"1980","journal-title":"Naunyn. Schmiedebergs. Arch. Pharm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF00498508","article-title":"Inactivation of the guanine nucleotide regulatory site mediating inhibition of the adenylate cyclase in hamster adipocytes","volume":"321","author":"Aktories","year":"1982","journal-title":"Naunyn. Schmiedebergs. Arch. Pharm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1124\/mol.59.2.349","article-title":"Characterization of a G protein-coupled receptor for nicotinic acid","volume":"59","author":"Lorenzen","year":"2001","journal-title":"Mol. Pharm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.amjcard.2007.09.080","article-title":"Nicotinic acid (niacin) receptor agonists: Will they be useful therapeutic agents?","volume":"100","author":"Kamanna","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tips.2006.05.008","article-title":"The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target","volume":"27","author":"Offermanns","year":"2006","journal-title":"Trends Pharm. Sci."},{"key":"ref_15","unstructured":"Richard, R.N. (2011). 7 - biological and pharmacological roles of HCA receptors. Pharmacology of G Protein Coupled Receptors, Academic Press."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fendo.2011.00051","article-title":"Biological roles and therapeutic potential of hydroxy-carboxylic Acid receptors","volume":"2","author":"Ahmed","year":"2011","journal-title":"Front. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7600\/jpfsm.5.213","article-title":"Biological roles and therapeutic potential of G protein-coupled receptors for free fatty acids and metabolic intermediates","volume":"5","author":"Suzuki","year":"2016","journal-title":"J. Phys. Fit. Sports Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4161\/gmic.28681","article-title":"Metabolic tinkering by the gut microbiome: Implications for brain development and function","volume":"5","author":"Selkrig","year":"2014","journal-title":"Gut Microbes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.metabol.2015.10.001","article-title":"Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2","volume":"65","author":"Graff","year":"2016","journal-title":"Metabolism"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"16767","DOI":"10.1073\/pnas.0808567105","article-title":"Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41","volume":"105","author":"Samuel","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1017\/S0007114512003923","article-title":"Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content","volume":"109","author":"Bellahcene","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Giri, B., Belanger, K., Seamon, M., Bradley, E., Purohit, S., Chong, R., Morgan, J.C., Baban, B., and Wakade, C. (2019). Niacin ameliorates neuro-inflammation in Parkinson\u2019s disease via GPR109A. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184559"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4518023","DOI":"10.1155\/2020\/4518023","article-title":"Minireview on the relations between gut microflora and Parkinson\u2019s disease: Further biochemical (oxidative stress), inflammatory, and neurological particularities","volume":"2020","author":"Ilie","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Gasperi, V., Sibilano, M., Savini, I., and Catani, M.V. (2019). Niacin in the central nervous system: An update of biological aspects and clinical applications. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040974"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(04)00416-7","article-title":"Discoveries of nicotinamide riboside as a nutrient and conserved nrk genes establish a preiss-handler independent route to NAD+ in fungi and humans","volume":"117","author":"Bieganowski","year":"2004","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1210\/er.2009-0026","article-title":"The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways","volume":"31","author":"Houtkooper","year":"2010","journal-title":"Endocr. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.gde.2017.03.014","article-title":"NMNAT: It\u2019s an NAD(+) synthase\u2026 It\u2019s a chaperone\u2026 It\u2019s a neuroprotector","volume":"44","author":"Brazill","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cmet.2015.05.023","article-title":"NAD(+) metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus","volume":"22","author":"Menzies","year":"2015","journal-title":"Cell Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1039\/cs9952400401","article-title":"Chemistry and neurochemistry of the kynurenine pathway of tryptophan metabolism","volume":"24","author":"Botting","year":"1995","journal-title":"Chem. Soc. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.bbapap.2016.06.014","article-title":"NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy","volume":"1864","author":"Yang","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Balmus, I.-M., Ilie-Dumitru, O., Ciobica, A., Cojocariu, R.-O., Stanciu, C., Trifan, A., Cimpeanu, M., Cimpeanu, C., and Gorgan, L. (2020). Irritable bowel syndrome between molecular approach and clinical expertise\u2014Searching for gap fillers in the oxidative stress way of thinking. Medicina, 56.","DOI":"10.3390\/medicina56010038"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e33246","DOI":"10.7554\/eLife.33246","article-title":"Nicotinamide adenine dinucleotide is transported into mammalian mitochondria","volume":"7","author":"Davila","year":"2018","journal-title":"Elife"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00018-009-0190-4","article-title":"Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation","volume":"67","author":"Niere","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/BJ20111420","article-title":"The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+","volume":"443","author":"Agrimi","year":"2012","journal-title":"Biochem. J."},{"key":"ref_37","first-page":"1","article-title":"Hexose-6-phosphate dehydrogenase in the endoplasmic reticulum","volume":"391","author":"Senesi","year":"2009","journal-title":"Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00018-014-1745-6","article-title":"ARTC1-mediated ADP-ribosylation of GRP78\/BiP: A new player in endoplasmic-reticulum stress responses","volume":"72","author":"Fabrizio","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3109\/10409238.2015.1028612","article-title":"The human NAD metabolome: Functions, metabolism and compartmentalization","volume":"50","author":"Nikiforov","year":"2015","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_40","unstructured":"Eskin, M.N.A. (2018). Chapter three - Niacin. New Research and Developments of Water-Soluble Vitamins, Academic Press."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1615\/CritRevEukaryotGeneExpr.2013006875","article-title":"Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases","volume":"24","author":"Morales","year":"2014","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nchembio.2568","article-title":"Insights into the biogenesis, function, and regulation of ADP-ribosylation","volume":"14","author":"Cohen","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1111\/febs.14078","article-title":"ADP-ribosylation: New facets of an ancient modification","volume":"284","author":"Palazzo","year":"2017","journal-title":"Febs J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.dnarep.2014.05.003","article-title":"Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life","volume":"23","author":"Perina","year":"2014","journal-title":"DNA Repair"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/pmic.201400217","article-title":"Proteomics approaches to identify mono-(ADP-ribosyl)ated and poly(ADP-ribosyl)ated proteins","volume":"15","author":"Vivelo","year":"2015","journal-title":"Proteomics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1158\/2159-8290.CD-16-0860","article-title":"Targeting DNA repair in cancer: Beyond PARP inhibitors","volume":"7","author":"Brown","year":"2017","journal-title":"Cancer Discov."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/cpr.12268","article-title":"The PARP family: Insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival","volume":"49","author":"Jubin","year":"2016","journal-title":"Cell Prolif."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jacobson, M., and Jacobson, E. (2002). Therapeutic targeting of the PARPs: Future challenges, future opportunities. PARP as a Therapeutic Target, CRC Press.","DOI":"10.1201\/9781420042405.ch15"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/emboj\/19.6.1176","article-title":"Acetylation: A regulatory modification to rival phosphorylation?","volume":"19","author":"Kouzarides","year":"2000","journal-title":"Embo J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1038\/sj.onc.1210599","article-title":"HATs and HDACs: From structure, function and regulation to novel strategies for therapy and prevention","volume":"26","author":"Yang","year":"2007","journal-title":"Oncogene"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.bbadis.2015.08.017","article-title":"Sirtuin regulation in aging and injury","volume":"1852","author":"Poulose","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1091\/mbc.e05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins","volume":"16","author":"Michishita","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20070140","article-title":"Sirtuins in mammals: Insights into their biological function","volume":"404","author":"Michan","year":"2007","journal-title":"Biochem. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: Biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Houtkooper, R.H. (2016). NAD+ as a pharmacological tool to boost sirtuin activity bt - sirtuins. Sirtuins, Springer.","DOI":"10.1007\/978-94-024-0962-8"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Silvestre, R., and Torrado, E. (2018). Alterations on cellular redox states upon infection and implications for host cell homeostasis BT - Metabolic interaction in infection. Metabolic Interaction in Infection, Springer International Publishing.","DOI":"10.1007\/978-3-319-74932-7"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/cyto.b.21092","article-title":"CD38 and CD157: A long journey from activation markers to multifunctional molecules","volume":"84B","author":"Quarona","year":"2013","journal-title":"Cytom. Part B Clin. Cytom."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium Signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.pharmtox.41.1.317","article-title":"Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers","volume":"41","author":"Lee","year":"2001","journal-title":"Annu. Rev. Pharm. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1152\/physrev.00035.2007","article-title":"Evolution and function of the ADP ribosyl cyclase\/CD38 gene family in physiology and pathology","volume":"88","author":"Malavasi","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"H208","DOI":"10.1152\/ajpheart.2001.280.1.H208","article-title":"cADP-ribose activates reconstituted ryanodine receptors from coronary arterial smooth muscle","volume":"280","author":"Li","year":"2001","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ceca.2010.05.001","article-title":"Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals","volume":"47","author":"Patel","year":"2010","journal-title":"Cell Calcium"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/35079100","article-title":"ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology","volume":"411","author":"Perraud","year":"2001","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.apsb.2016.11.001","article-title":"Targeting calcium signaling in cancer therapy","volume":"7","author":"Cui","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1101\/gad.1199904","article-title":"Alkylating DNA damage stimulates a regulated form of necrotic cell death","volume":"18","author":"Zong","year":"2004","journal-title":"Genes Dev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1376506","article-title":"Necrotic death as a cell fate","volume":"20","author":"Zong","year":"2006","journal-title":"Genes Dev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1097\/NEN.0b013e3181f7e7e9","article-title":"Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis","volume":"69","author":"Bellac","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yexcr.2015.05.019","article-title":"Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner","volume":"335","author":"Takeuchi","year":"2015","journal-title":"Exp. Cell Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1084\/jem.183.2.463","article-title":"Biochemical pathways of apoptosis: Nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentation","volume":"183","author":"Wright","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1073\/pnas.98.3.1188","article-title":"Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1","volume":"98","author":"Asher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"7063874","DOI":"10.1155\/2017\/7063874","article-title":"nicotinamide adenine dinucleotide protects against spinal cord ischemia reperfusion injury-induced apoptosis by blocking autophagy","volume":"2017","author":"Xie","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"34643","DOI":"10.1074\/jbc.M400078200","article-title":"Reactive oxygen species produced by Nad(P)H oxidase inhibit apoptosis in pancreatic cancer cells","volume":"279","author":"Vaquero","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/01.WCB.0000122746.72175.0E","article-title":"The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential","volume":"24","author":"Chong","year":"2004","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3892\/etm.2014.1842","article-title":"Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson\u2019s disease","volume":"8","author":"Lu","year":"2014","journal-title":"Exp. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1042\/bj3530357","article-title":"Oxidation of pyridine nucleotides during Fas- and ceramide-induced apoptosis in Jurkat cells: Correlation with changes in mitochondria, glutathione depletion, intracellular acidification and caspase 3 activation","volume":"353","author":"Gendron","year":"2001","journal-title":"Biochem. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-4157(95)00003-A","article-title":"The mitochondrial permeability transition","volume":"1241","author":"Zoratti","year":"1995","journal-title":"Biochim. Biophys. Acta - Rev. Biomembr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0009-2797(92)90026-H","article-title":"NADH-Dependent reductive stress and ferritin-bound iron in allyl alcohol-induced lipid peroxidation in vivo: The protective effect of vitamin E","volume":"81","author":"Jaeschke","year":"1992","journal-title":"Chem. Biol. Interact."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"Embo J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1124\/mol.106.023515","article-title":"Mitochondrial NADP+ - dependent isocitrate dehydrogenase protects cadmium-induced apoptosis","volume":"70","author":"Kil","year":"2006","journal-title":"Mol. Pharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.freeradbiomed.2006.09.016","article-title":"Oxalomalate regulates ionizing radiation-induced apoptosis in mice","volume":"42","author":"Lee","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/glia.10246","article-title":"Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure","volume":"43","author":"Ramos","year":"2003","journal-title":"Glia"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1098\/rstb.2005.1766","article-title":"The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides","volume":"360","author":"Abramov","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1523\/JNEUROSCI.4042-03.2004","article-title":"Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase","volume":"24","author":"Abramov","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1523\/JNEUROSCI.4468-06.2007","article-title":"Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation","volume":"27","author":"Abramov","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/ars.2007.9.49","article-title":"mechanisms of cell death in oxidative stress","volume":"9","author":"Ryter","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.4049\/jimmunol.170.4.2113","article-title":"Poly(ADP-Ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts","volume":"170","author":"Andreone","year":"2003","journal-title":"J. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1073\/pnas.052712399","article-title":"Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia","volume":"99","author":"Ha","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1101\/gad.1331805","article-title":"Poly(ADP-ribosyl)ation by PARP-1: \u2018PAR-laying\u2019 NAD+ into a nuclear signal","volume":"19","author":"Kim","year":"2005","journal-title":"Genes Dev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1042\/BJ20040593","article-title":"Dual regulation of AP-2alpha transcriptional activation by poly(ADP-ribose) polymerase-1","volume":"382","author":"Li","year":"2004","journal-title":"Biochem. J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mce.2006.06.008","article-title":"The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions","volume":"257\u2013258","author":"Li","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1038\/sj.onc.1207696","article-title":"Crosstalk between PARP-1 and NF-\u03baB modulates the promotion of skin neoplasia","volume":"23","author":"Valenzuela","year":"2004","journal-title":"Oncogene"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cell.2004.11.002","article-title":"NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1","volume":"119","author":"Kim","year":"2004","journal-title":"Cell"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj3420249","article-title":"Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions","volume":"342","author":"Desnoyers","year":"1999","journal-title":"Biochem. J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1073\/pnas.79.11.3423","article-title":"Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure","volume":"79","author":"Poirier","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1073\/pnas.94.6.2261","article-title":"Poly(ADP-ribose) polymerase enhances activator-dependent transcription","volume":"94","author":"Meisterernst","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"31644","DOI":"10.1074\/jbc.273.48.31644","article-title":"Regulation of RNA polymerase II-dependent Transcription by Poly(ADP-ribosyl)ation of transcription factors","volume":"273","author":"Oei","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1021\/bi9727390","article-title":"A novel function of poly(ADP-ribosyl)ation:\u2009 Silencing of RNA polymerase II-dependent transcription","volume":"37","author":"Oei","year":"1998","journal-title":"Biochemistry"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1038\/sj.onc.1209751","article-title":"Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1","volume":"25","author":"Amiri","year":"2006","journal-title":"Oncogene"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"9101","DOI":"10.1074\/jbc.M511049200","article-title":"Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene","volume":"281","author":"Yu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.onc.1208005","article-title":"Modulation of DNMT1 activity by ADP-ribose polymers","volume":"24","author":"Reale","year":"2005","journal-title":"Oncogene"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"7937","DOI":"10.1021\/bi970241s","article-title":"Does poly(ADP-ribosyl)ation regulate the DNA methylation pattern?","volume":"36","author":"Zardo","year":"1997","journal-title":"Biochemistry"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1096\/fasebj.13.12.1518","article-title":"Inhibition of poly(ADP-ribosyl)ation introduces an anomalous methylation pattern in transfected foreign DNA","volume":"13","author":"Zardo","year":"1999","journal-title":"Faseb J."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1096\/fj.01-0827fje","article-title":"Inhibition of poly(ADP-ribosyl)ation induces DNA hypermethylation: A possible molecular mechanism","volume":"16","author":"Zardo","year":"2002","journal-title":"Faseb J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0092-8674(01)00524-4","article-title":"Negative control of p53 by Sir2\u03b1 promotes cell survival under stress","volume":"107","author":"Luo","year":"2001","journal-title":"Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0092-8674(04)00126-6","article-title":"Mammalian SIRT1 Represses forkhead transcription factors","volume":"116","author":"Motta","year":"2004","journal-title":"Cell"},{"key":"ref_106","first-page":"2473","article-title":"The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity","volume":"116","author":"Nakae","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/jcp.20831","article-title":"SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity","volume":"210","author":"Dai","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Pagans, S., Pedal, A., North, B.J., Kaehlcke, K., Marshall, B.L., Dorr, A., Hetzer-Egger, C., Henklein, P., Frye, R., and McBurney, M.W. (2005). SIRT1 regulates HIV transcription via tat deacetylation. PLoS Biol., 3.","DOI":"10.1371\/journal.pbio.0030041"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1101\/gad.1399706","article-title":"Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription","volume":"20","author":"Ford","year":"2006","journal-title":"Genes Dev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/emboj\/20.6.1353","article-title":"Acetylation of TAF(I)68, a subunit of TIF-IB\/SL1, activates RNA polymerase I transcription","volume":"20","author":"Muth","year":"2001","journal-title":"Embo J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1089\/rej.2015.1767","article-title":"NAD+ as the link between oxidative stress, inflammation, caloric restriction, exercise, DNA repair, longevity, and health span","volume":"19","author":"Poljsak","year":"2016","journal-title":"Rejuvenation Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1474-9726.2010.00548.x","article-title":"Aging and disease: Connections to sirtuins","volume":"9","author":"Donmez","year":"2010","journal-title":"Aging Cell"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"132","DOI":"10.12688\/f1000research.12120.1","article-title":"NAD (+) biosynthesis, aging, and disease","volume":"7","author":"Johnson","year":"2018","journal-title":"F1000Research"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1073\/pnas.1417921112","article-title":"In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences","volume":"112","author":"Zhu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cmet.2016.07.005","article-title":"Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle","volume":"24","author":"Frederick","year":"2016","journal-title":"Cell Metab."},{"key":"ref_116","first-page":"1321","article-title":"Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging","volume":"33","author":"Stein","year":"2014","journal-title":"Embo J."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"10841","DOI":"10.1074\/jbc.C700018200","article-title":"Extension of human cell lifespan by nicotinamide phosphoribosyltransferase","volume":"282","author":"Ho","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.cell.2013.05.027","article-title":"SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.molcel.2015.01.034","article-title":"Biology of poly(ADP-Ribose) polymerases: The factotums of cell maintenance","volume":"58","author":"Bai","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cmet.2016.05.006","article-title":"CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism","volume":"23","author":"Chini","year":"2016","journal-title":"Cell Metab."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.freeradbiomed.2016.11.039","article-title":"Coordination of DNA single strand break repair","volume":"107","author":"Abbotts","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1515\/jomb-2017-0001","article-title":"Oxidative stress markers in GnRH agonist and antagonist protocols in IVF","volume":"36","year":"2017","journal-title":"J. Med. Biochem."},{"key":"ref_124","first-page":"149","article-title":"The effect of reactive oxygen species on embryo quality in IVF","volume":"30","author":"Siristatidis","year":"2016","journal-title":"In Vivo"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/rmb2.12229","article-title":"Evaluation of antioxidant status and oxidative stress markers in follicular fluid for human in vitro fertilization outcome","volume":"17","author":"Nishihara","year":"2018","journal-title":"Reprod. Med. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/19396368.2012.701367","article-title":"Oxidative stress markers in follicular fluid of women undergoing in vitro fertilization and embryo transfer","volume":"58","author":"Borowiecka","year":"2012","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_127","first-page":"S125","article-title":"Role of environmental factors & oxidative stress with respect to in vitro fertilization outcome","volume":"148","author":"Kumar","year":"2018","journal-title":"Indian J. Med. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.reprotox.2013.08.005","article-title":"Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF","volume":"42","author":"Singh","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12958-016-0184-7","article-title":"Antioxidants reduce oxidative stress in follicular fluid of aged women undergoing IVF","volume":"14","author":"Luddi","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1159\/000495051","article-title":"Niacin inhibits apoptosis and rescues premature ovarian failure","volume":"50","author":"Wang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Lefter, R., Ciobica, A., Timofte, D., Stanciu, C., and Trifan, A. (2019). A descriptive review on the prevalence of gastrointestinal disturbances and their multiple associations in autism spectrum disorder. Medicina, 56.","DOI":"10.3390\/medicina56010011"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"150","DOI":"10.37358\/RC.20.1.7826","article-title":"The modulation of oxytocin and cortisol levels in major depression disorder and irritable bowel syndrome","volume":"71","author":"Hritcu","year":"2020","journal-title":"Rev. Chim."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Sfarti, C., Ciobica, A., Balmus, I.-M., Ilie, O.-D., Trifan, A., Petrea, O., Cojocariu, C., G\u00eerleanu, I., S\u00eengeap, A.M., and Stanciu, C. (2020). Systemic oxidative stress markers in cirrhotic patients with hepatic encephalopathy: Possible connections with systemic ammoniemia. Medicina, 56.","DOI":"10.3390\/medicina56040196"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.3168\/jds.2016-12480","article-title":"Antioxidant status and gut microbiota change in an aging mouse model as influenced by exopolysaccharide produced by Lactobacillus plantarum YW11 isolated from Tibetan kefir","volume":"100","author":"Zhang","year":"2017","journal-title":"J. Dairy Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1039\/C7FO01574G","article-title":"Lactobacillus plantarum CCFM10 alleviating oxidative stress and restoring the gut microbiota in d-galactose-induced aging mice","volume":"9","author":"Zhao","year":"2018","journal-title":"Food Funct."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"12138","DOI":"10.1038\/s41598-018-30691-4","article-title":"Oxidative stress decreases the redox ratio and folate content in the gut microbe, enterococcus durans (MTCC 3031)","volume":"8","author":"Jose","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e35987","DOI":"10.7554\/eLife.35987","article-title":"Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut","volume":"7","author":"Reese","year":"2018","journal-title":"Elife"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1901012","DOI":"10.1002\/mnfr.201901012","article-title":"oxidized pork induces oxidative stress and inflammation by altering gut microbiota in mice","volume":"64","author":"Ge","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jff.2019.05.009","article-title":"Extruded sorghum (Sorghum bicolor L.) improves gut microbiota, reduces inflammation, and oxidative stress in obese rats fed a high-fat diet","volume":"58","author":"Grancieri","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Yuzefpolskaya, M., Bohn, B., Nasiri, M., Zuver, A.M., Onat, D.D., Royzman, E.A., Nwokocha, J., Mabasa, M., Pinsino, A., and Brunjes, D. (2020). Gut microbiota, endotoxemia, inflammation, and oxidative stress in patients with heart failure, left ventricular assist device, and transplant. J. Heart Lung Transplant.","DOI":"10.1016\/j.healun.2020.02.004"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"307","DOI":"10.15562\/bmj.v8i1.1285","article-title":"Thiol-producing microbiota of the intestine modulate oxidative stress and inflammation in Chronic Kidney Disease","volume":"8","author":"Kadariswantiningsih","year":"2019","journal-title":"Bali Med. J."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Bhalla, P., Rengaswamy, R., Karunagaran, D., Suraishkumar, G.K., and Sahoo, S. (2019). Silver nanoparticle induced oxidative stress augments anticancer gut bacterial metabolites production. bioRxiv, 658609.","DOI":"10.1101\/658609"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/toxsci\/kfx174","article-title":"The effects of an environmentally relevant level of arsenic on the gut microbiome and its functional metagenome","volume":"160","author":"Chi","year":"2017","journal-title":"Toxicol. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jad.2012.05.022","article-title":"The relevance of oxidative stress status in first episode and recurrent depression","volume":"143","author":"Stefanescu","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2009.11.033","article-title":"Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer\u2019s disease","volume":"469","author":"Padurariu","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"7156928","DOI":"10.1155\/2017\/7156928","article-title":"Preliminary data on the interaction between some biometals and oxidative stress status in mild cognitive impairment and Alzheimer\u2019s disease patients","volume":"2017","author":"Strungaru","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3975101","DOI":"10.1155\/2016\/3975101","article-title":"Oxidative stress implications in the affective disorders: Main biomarkers, animal models relevance, genetic perspectives, and antioxidant approaches","volume":"2016","author":"Balmus","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/1319-3767.173753","article-title":"The implications of oxidative stress and antioxidant therapies in inflammatory bowel disease: Clinical aspects and animal models","volume":"22","author":"Balmus","year":"2016","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_150","first-page":"237","article-title":"Oxidative stress in schizophrenia - Focusing on the main markers","volume":"23","author":"Ciobica","year":"2011","journal-title":"Psychiatr. Danub."},{"key":"ref_151","first-page":"401","article-title":"The oxidative stress hypothesis in Alzheimer\u2019s disease","volume":"25","author":"Padurariu","year":"2013","journal-title":"Psychiatr. Danub."},{"key":"ref_152","first-page":"265","article-title":"Gut-lung axis and dysbiosis in COVID-19","volume":"44","author":"Aktas","year":"2020","journal-title":"Turk. J. Biol. Turk Biyol. Derg."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"m606","DOI":"10.1136\/bmj.m606","article-title":"Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series","volume":"368","author":"Xu","year":"2020","journal-title":"BMJ"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/gutjnl-2020-320926","article-title":"Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms","volume":"69","author":"Jin","year":"2020","journal-title":"Gut"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus\u2013Infected pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1136\/gutjnl-2020-321013","article-title":"Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection","volume":"69","author":"Lin","year":"2020","journal-title":"Gut"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1136\/gutjnl-2020-320953","article-title":"Digestive system is a potential route of COVID-19: An analysis of single-cell coexpression pattern of key proteins in viral entry process","volume":"69","author":"Zhang","year":"2020","journal-title":"Gut"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1136\/gutjnl-2020-321051","article-title":"COVID-19 in gastroenterology: A clinical perspective","volume":"69","author":"Ong","year":"2020","journal-title":"Gut"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1136\/gutjnl-2020-320891","article-title":"SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19","volume":"69","author":"Song","year":"2020","journal-title":"Gut"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1136\/gutjnl-2020-320832","article-title":"Diarrhoea may be underestimated: A missing link in 2019 novel coronavirus","volume":"69","author":"Liang","year":"2020","journal-title":"Gut"},{"key":"ref_165","first-page":"59","article-title":"Irritable bowel syndrome subtypes: Clinical and psychological features, body mass index and comorbidities","volume":"108","year":"2016","journal-title":"Rev. Espa\u00f1ola Enferm. Dig."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmgh.2018.04.003","article-title":"The brain-gut-microbiome axis","volume":"6","author":"Martin","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"m1091","DOI":"10.1136\/bmj.m1091","article-title":"Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study","volume":"368","author":"Chen","year":"2020","journal-title":"BMJ"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/gutjnl-2017-315545","article-title":"Comparison of different histological indexes in the assessment of UC activity and their accuracy regarding endoscopic outcomes and faecal calprotectin levels","volume":"68","author":"Magro","year":"2019","journal-title":"Gut"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1136\/gutjnl-2020-321388","article-title":"Faecal calprotectin indicates intestinal inflammation in COVID-19","volume":"69","author":"Effenberger","year":"2020","journal-title":"Gut"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/apt.15804","article-title":"2019 novel coronavirus disease (COVID-19) in patients with inflammatory bowel diseases","volume":"52","author":"Taxonera","year":"2020","journal-title":"Aliment. Pharm."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1136\/gutjnl-2020-321183","article-title":"A fatal case of COVID-19 pneumonia occurring in a patient with severe acute ulcerative colitis","volume":"69","author":"Mazza","year":"2020","journal-title":"Gut"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S2468-1253(20)30083-2","article-title":"Prolonged presence of SARS-CoV-2 viral RNA in faecal samples","volume":"5","author":"Wu","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMoa2001191","article-title":"First Case of 2019 Novel Coronavirus in the United States","volume":"382","author":"Holshue","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"m1443","DOI":"10.1136\/bmj.m1443","article-title":"Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: Retrospective cohort study","volume":"369","author":"Zheng","year":"2020","journal-title":"BMJ"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"101964","DOI":"10.1016\/j.jflm.2020.101964","article-title":"COVID-19 in forensic medicine unit personnel: Observation from Thailand","volume":"72","author":"Sriwijitalai","year":"2020","journal-title":"J. Forensic Leg. Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1053\/j.gastro.2020.02.055","article-title":"Evidence for gastrointestinal infection of SARS-CoV-2","volume":"158","author":"Xiao","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/1751-2980.12851","article-title":"2019 novel coronavirus infection and gastrointestinal tract","volume":"21","author":"Gao","year":"2020","journal-title":"J. Dig. Dis."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Yang, Y., Shen, C., Li, J., Yuan, J., Yang, M., Wang, F., Li, G., Li, Y., Xing, L., and Peng, L. (2020). Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome. medRxiv.","DOI":"10.1101\/2020.03.02.20029975"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Gou, W., Fu, Y., Yue, L., Chen, G., Cai, X., Shuai, M., Xu, F., Yi, X., Chen, H., and Zhu, Y.J. (2020). Gut microbiota may underlie the predisposition of healthy individuals to COVID-19. medRxiv.","DOI":"10.1101\/2020.04.22.20076091"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jmii.2020.04.015","article-title":"ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome","volume":"53","author":"Devaux","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature11228","article-title":"ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation","volume":"487","author":"Hashimoto","year":"2012","journal-title":"Nature"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41368-020-0074-x","article-title":"High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa","volume":"12","author":"Xu","year":"2020","journal-title":"Int. J. Oral Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41423-020-0402-2","article-title":"Functional exhaustion of antiviral lymphocytes in COVID-19 patients","volume":"17","author":"Zheng","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/infdis\/jiaa150","article-title":"Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia","volume":"221","author":"Wang","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cell.2017.05.034","article-title":"Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways","volume":"170","author":"Bellono","year":"2017","journal-title":"Cell"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/mi.2015.121","article-title":"Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria","volume":"9","author":"Rios","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"eabc3582","DOI":"10.1126\/sciimmunol.abc3582","article-title":"TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes","volume":"5","author":"Zang","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abc1669","article-title":"SARS-CoV-2 productively infects human gut enterocytes","volume":"369","author":"Lamers","year":"2020","journal-title":"Science"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41591-020-0817-4","article-title":"Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding","volume":"26","author":"Xu","year":"2020","journal-title":"Nat. Med."},{"key":"ref_191","first-page":"1843","article-title":"Detection of SARS-CoV-2 in different types of clinical specimens","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41591-020-0897-1","article-title":"Antibody responses to SARS-CoV-2 in patients with COVID-19","volume":"26","author":"Long","year":"2020","journal-title":"Nat. Med."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Carrouel, F., Conte, M.P., Fisher, J., Gon\u00e7alves, L.S., Dussart, C., Llodra, J.C., and Bourgeois, D. (2020). COVID-19: A recommendation to examine the effect of mouthrinses with \u03b2-cyclodextrin combined with citrox in preventing infection and progression. J. Clin. Med., 9.","DOI":"10.3390\/jcm9041126"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/jac\/dkaa114","article-title":"COVID-19: A recommendation to examine the effect of hydroxychloroquine in preventing infection and progression","volume":"75","author":"Zhou","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1038\/s41598-020-61912-4","article-title":"Effects of Chlorhexidine mouthwash on the oral microbiome","volume":"10","author":"Bescos","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"198018","DOI":"10.1016\/j.virusres.2020.198018","article-title":"Gut microbiota and Covid-19- possible link and implications","volume":"285","author":"Dhar","year":"2020","journal-title":"Virus Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/15\/3323\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:50:50Z","timestamp":1760176250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/15\/3323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":196,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["molecules25153323"],"URL":"https:\/\/doi.org\/10.3390\/molecules25153323","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]}}}